High prevalence of lipoatrophy in pre-pubertal South African children on antiretroviral therapy: a cross-sectional study

Autor: Innes Steve, Cotton Mark F, Haubrich Richard, Conradie Maria M, van Niekerk Margaret, Edson Clair, Rabie Helena, Jain Sonia, Sun Xiaoying, Zöllner Ekkehard W, Hough Stephen, Browne Sara H

Publikováno v: BMC Pediatrics, Vol 12, Iss 1, p 183 (2012)

Abstract Background Despite changes in WHO guidelines, stavudine is still used extensively for treatment of pediatric HIV in the developing world. Lipoatrophy in sub-Saharan African children can be stigmatizing and have far-reaching consequences. The

Externí odkaz: https://doaj.org/article/e4823541993a4c429be5334c22231f35

Next generation sequencing improves detection of drug resistance mutations in infants after PMTCT failure

Autor: Fisher, Randall G, Smith, Davey M, Murrell, Ben, Slabbert, Ruhan, Kirby, Bronwyn M, Edson, Clair, Cotton, Mark F, Haubrich, Richard H, Kosakovsky Pond, Sergei L, Van Zyl, Gert U

Publikováno v: Fisher, Randall G; Smith, Davey M; Murrell, Ben; Slabbert, Ruhan; Kirby, Bronwyn M; Edson, Clair; et al.(2015). Next generation sequencing improves detection of drug resistance mutations in infants after PMTCT failure.. Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 62, 48-53. doi: 10.1016/j.jcv.2014.11.014. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/7s00s5qc

Next generation sequencing (NGS) allows the detection of minor variant HIV drug resistance mutations (DRMs). However data from new NGS platforms after Prevention-of-Mother-to-Child-Transmission (PMTCT) regimen failure are limited.To compare major and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::00243f16d9b25f5573d0248c91f50fa5
http://www.escholarship.org/uc/item/7s00s5qc