Specific quinone reductase 2 inhibitors reduce metabolic burden and reverse Alzheimer's disease phenotype in mice.

Autor: Gould NL; Sagol Department of Neurobiology, University of Haifa, Haifa, Israel., Scherer GR; Sagol Department of Neurobiology, University of Haifa, Haifa, Israel., Carvalho S; Wohl Institute for Drug Discovery of the Nancy and Stephen Grand Israeli National Center for Personalized Medicine (GINCPM), Weizmann Institute of Science, Rehovot, Israel., Shurrush K; Wohl Institute for Drug Discovery of the Nancy and Stephen Grand Israeli National Center for Personalized Medicine (GINCPM), Weizmann Institute of Science, Rehovot, Israel., Kayyal H; Sagol Department of Neurobiology, University of Haifa, Haifa, Israel., Edry E; Sagol Department of Neurobiology, University of Haifa, Haifa, Israel.; The Centre for Genetic Manipulation in the Brain, University of Haifa, Haifa, Israel., Elkobi A; Sagol Department of Neurobiology, University of Haifa, Haifa, Israel., David O; Sagol Department of Neurobiology, University of Haifa, Haifa, Israel., Foqara M; Sagol Department of Neurobiology, University of Haifa, Haifa, Israel., Thakar D; Sagol Department of Neurobiology, University of Haifa, Haifa, Israel., Pavesi T; Sagol Department of Neurobiology, University of Haifa, Haifa, Israel., Sharma V; Department of Biomedical Sciences, University of Windsor, Windsor, Ontario, Canada., Walker M; Department of Biochemistry, The University of Western Ontario, London, Ontario, Canada., Maitland M; Department of Biochemistry, The University of Western Ontario, London, Ontario, Canada., Dym O; Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot, Israel., Albeck S; Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot, Israel., Peleg Y; Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot, Israel., Germain N; Wohl Institute for Drug Discovery of the Nancy and Stephen Grand Israeli National Center for Personalized Medicine (GINCPM), Weizmann Institute of Science, Rehovot, Israel., Babaev I; Wohl Institute for Drug Discovery of the Nancy and Stephen Grand Israeli National Center for Personalized Medicine (GINCPM), Weizmann Institute of Science, Rehovot, Israel., Sharir H; Wohl Institute for Drug Discovery of the Nancy and Stephen Grand Israeli National Center for Personalized Medicine (GINCPM), Weizmann Institute of Science, Rehovot, Israel., Lalzar M; Bioinformatics Service Unit and., Shklyar B; Bioimaging Unit, Faculty of Natural Sciences, University of Haifa, Haifa, Israel., Hazut N; Sagol Department of Neurobiology, University of Haifa, Haifa, Israel., Khamaisy M; Sagol Department of Neurobiology, University of Haifa, Haifa, Israel., Lévesque M; Montreal Neurological Institute-Hospital and Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada., Lajoie G; Department of Biochemistry, The University of Western Ontario, London, Ontario, Canada., Avoli M; Montreal Neurological Institute-Hospital and Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada., Amitai G; Wohl Institute for Drug Discovery of the Nancy and Stephen Grand Israeli National Center for Personalized Medicine (GINCPM), Weizmann Institute of Science, Rehovot, Israel., Lefker B; Wohl Institute for Drug Discovery of the Nancy and Stephen Grand Israeli National Center for Personalized Medicine (GINCPM), Weizmann Institute of Science, Rehovot, Israel., Subramanyam C; Wohl Institute for Drug Discovery of the Nancy and Stephen Grand Israeli National Center for Personalized Medicine (GINCPM), Weizmann Institute of Science, Rehovot, Israel., Shilton B; Department of Biochemistry, The University of Western Ontario, London, Ontario, Canada., Barr H; Wohl Institute for Drug Discovery of the Nancy and Stephen Grand Israeli National Center for Personalized Medicine (GINCPM), Weizmann Institute of Science, Rehovot, Israel., Rosenblum K; Sagol Department of Neurobiology, University of Haifa, Haifa, Israel.; The Centre for Genetic Manipulation in the Brain, University of Haifa, Haifa, Israel.

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2023 Oct 02; Vol. 133 (19). Date of Electronic Publication: 2023 Oct 02.

Dopamine-Dependent QR2 Pathway Activation in CA1 Interneurons Enhances Novel Memory Formation.

Autor: Gould NL; Sagol Department of Neuroscience, University of Haifa, Mount Carmel, Haifa, 3498838, Israel., Sharma V; Sagol Department of Neuroscience, University of Haifa, Mount Carmel, Haifa, 3498838, Israel., Hleihil M; Sagol Department of Neuroscience, University of Haifa, Mount Carmel, Haifa, 3498838, Israel., Kolatt Chandran S; Sagol Department of Neuroscience, University of Haifa, Mount Carmel, Haifa, 3498838, Israel., David O; Sagol Department of Neuroscience, University of Haifa, Mount Carmel, Haifa, 3498838, Israel., Edry E; Sagol Department of Neuroscience, University of Haifa, Mount Carmel, Haifa, 3498838, Israel.; Center for Gene Manipulation in the Brain, University of Haifa, Mount Carmel, Haifa, 3498838, Israel., Rosenblum K; Sagol Department of Neuroscience, University of Haifa, Mount Carmel, Haifa, 3498838, Israel kobir@psy.haifa.ac.il.; Center for Gene Manipulation in the Brain, University of Haifa, Mount Carmel, Haifa, 3498838, Israel.

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2020 Nov 04; Vol. 40 (45), pp. 8698-8714. Date of Electronic Publication: 2020 Oct 12.

Quintessential Synergy: Concurrent Transient Administration of Integrated Stress Response Inhibitors and BACE1 and/or BACE2 Activators as the Optimal Therapeutic Strategy for Alzheimer's Disease.

Autor: Volloch, Vladimir¹ (AUTHOR) vladimir.volloch@gmail.com, Rits-Volloch, Sophia^2,3 (AUTHOR) vladimir.volloch@gmail.com

Publikováno v: International Journal of Molecular Sciences. Sep2024, Vol. 25 Issue 18, p9913. 72p.

Brain Abnormalities in Young Single- and Double-Heterozygote Mice for Both Nkx2-1- and Pax8-Null Mutations.

Autor: Giacco A; Department of Science and Technology, University of Sannio, Via De Sanctis, 82100, Benevento, Italy., Iervolino S; Department of Science and Technology, University of Sannio, Via De Sanctis, 82100, Benevento, Italy., Cioffi F; Department of Science and Technology, University of Sannio, Via De Sanctis, 82100, Benevento, Italy., Peluso T; Department of Science and Technology, University of Sannio, Via De Sanctis, 82100, Benevento, Italy., Mercurio G; Department of Science and Technology, University of Sannio, Via De Sanctis, 82100, Benevento, Italy., Roberto L; Biogem, Biology and Molecular Genetics Institute, Via Camporeale, 83031, Ariano Irpino, Av, Italy., de Rosa V; Division of Pharmacology, Department of Neuroscience, Reproductive and Dentistry Sciences, School of Medicine, Federico II University of Naples, Via Pansini, 5, 80131, Naples, Italy., Cammarota M; Division of Pharmacology, Department of Neuroscience, Reproductive and Dentistry Sciences, School of Medicine, Federico II University of Naples, Via Pansini, 5, 80131, Naples, Italy., Varricchio S; Department of Advanced Biomedical Sciences, Pathology Section, University of Naples Federico II, 80131, Naples, Italy., Staibano S; Department of Advanced Biomedical Sciences, Pathology Section, University of Naples Federico II, 80131, Naples, Italy., Boscia F; Division of Pharmacology, Department of Neuroscience, Reproductive and Dentistry Sciences, School of Medicine, Federico II University of Naples, Via Pansini, 5, 80131, Naples, Italy., Canzoniero LMT; Department of Science and Technology, University of Sannio, Via De Sanctis, 82100, Benevento, Italy., De Felice M; Institute of Experimental Endocrinology and Oncology (IEOS), CNR, Via Pansini 6, 80131, Naples, Italy.; Department of Molecular Medicine and Medical Biotechnologies, University of Naples Federico II, Via Pansini 6, 80131, Naples, Italy., Ambrosino C; Department of Science and Technology, University of Sannio, Via De Sanctis, 82100, Benevento, Italy.; Biogem, Biology and Molecular Genetics Institute, Via Camporeale, 83031, Ariano Irpino, Av, Italy.; Institute of Experimental Endocrinology and Oncology (IEOS), CNR, Via Pansini 6, 80131, Naples, Italy., Moreno M; Department of Science and Technology, University of Sannio, Via De Sanctis, 82100, Benevento, Italy., Silvestri E; Department of Science and Technology, University of Sannio, Via De Sanctis, 82100, Benevento, Italy. silvestri@unisannio.it.

Publikováno v: Molecular neurobiology [Mol Neurobiol] 2024 Oct 08. Date of Electronic Publication: 2024 Oct 08.

Local Inhibition of PERK Enhances Memory and Reverses Age-Related Deterioration of Cognitive and Neuronal Properties.

Autor: Sharma V; Sagol Department of Neurobiology and., Ounallah-Saad H; Sagol Department of Neurobiology and., Chakraborty D; Sagol Department of Neurobiology and., Hleihil M; Sagol Department of Neurobiology and., Sood R; Sagol Department of Neurobiology and., Barrera I; Sagol Department of Neurobiology and., Edry E; Center for Gene Manipulation in the Brain, University of Haifa, Haifa 3498838, Israel., Kolatt Chandran S; Sagol Department of Neurobiology and., Ben Tabou de Leon S; Sagol Department of Neurobiology and., Kaphzan H; Sagol Department of Neurobiology and., Rosenblum K; Sagol Department of Neurobiology and kobir@psy.haifa.ac.il.; Center for Gene Manipulation in the Brain, University of Haifa, Haifa 3498838, Israel.

Publikováno v: The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2018 Jan 17; Vol. 38 (3), pp. 648-658. Date of Electronic Publication: 2017 Dec 01.