Applying Epidemiology-Based Outcomes Research to Clinical Decision-Making

Autor: Cynthia A. Walawander, Edward C. Y. Wang, Thaddeus H. Grasela

Publikováno v: PharmacoEconomics. 15:385-393

Sepsis occurs in a heterogeneous population. A prospective nationwide surveillance study found that populations stratified by infection type had significant differences in the incidence of sepsis syndrome, rate of complications and mortality. The obj

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45f76a26d3a04c282348eb5cd24d82ab
https://doi.org/10.2165/00019053-199915040-00006

Pharmacokinetics of Edobacomab in Experimental Animals

Autor: Shuichi Yokoyama, Kaneo Sekiguchi, Hitomi Nakamura, Kazunori Enogaki, Kin-o Shimooka

Publikováno v: Drug Metabolism and Pharmacokinetics. 10:484-496

The plasma level, distribution, metabolism and excretion of Edobacomab, a novel anti-endotoxin mouse IgM monoclonal antibody were investigated after intravenous administration of [3H]Edobacomab and unlabelled Edobacomab to experimental animals.1. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::87b651fb7e0aa44e8c2d85cb4019fe12
https://doi.org/10.2133/dmpk.10.484

[Phase II study of edobacomab (E5) in the treatment of gram-negative sepsis]

Autor: Hiroyuki KOBAYASHI, Shin KAWAI, Susumu SAKAYORI, Masamitsu KANEKO, Yasushi ITO, Yoshihito UJIIE, Kenji KOBAYASHI, Hitoshi IMAIZUMI, Shuitsu HOSHI, Shigeatsu ENDO, Ryouichi MOTOKI, Hitoshi INOUE, Gouichi ENDO, Masaaki ARAKAWA, Kouichi WADA, Hiroyuki HIRASAWA, Shigeto ODA, Hidetoshi SHIGA, Kunio KOBAYASHI, Takashi HIGO, Otohiko KUNII, Yasuo ONO, Hajime NISHIYA, Takeshi SATO, Kyuya ISHIBIKI, Masakazu UEDA, Kaoru SHIMADA, Satoshi KIMURA, Iwao KOMURO, Hajime GOTO, Takashi INAMATSU, Makiko FUKAYAMA, Izumi HAYASHI, Masao ICHIKI, Shuji SHIMAZAKI, Tetsuo YUKIOKA, Shoichi OOTA, Yasuyuki YONEDA, Takashi OOWADA, Katsuhiko SUGIMOTO, Shoichiro IRIMAJIRI, Yasuo OOSONE, Jyun TAKEZAWA, Toshio FUKUOKA, Jirou YURA, Nagao SHINAGAWA, Shu ISHIKAWA, Hirotada KATSUYA, Kiyoshi ISHIKAWA, Toshiyuki YAMAMOTO, Kanzou SUZUKI, Touru MATSUURA, Ikuto YOSHIYA, Nobuyuki TAENAKA, Kikushi KATSURADA, Hiroshi NISHIO, Keiji KUMON, Naoki YAHAGI, Ikuto SAKATA, Jirou MARUYAMA, Hiroshi TANIMURA, Makoto IWAHASHI, Shizuma MIZOBATA, Masahiro SHINOZAKI, Toshio NAKA, Chiiho FUJII, Mitsuhiro FUKUDA, Shinichi ISHIMATSU, Rinzo SOEJIMA, Yoshihito NIKI, Hiroshi TATARA, Takashi YOKOYAMA, Takashi KODAMA, Hiroaki TSUMURA, Katsurou YAGAWA, Nobuo KAKU, Mitsuo SOU, Toshimi TSUNEYOSHI, Kohei HARA, Shigeru KOHNO, Hironobu KOGA, Kazunori TOMONO, Yuuichi INOUE, Takakazu OTSUBO, Sadahiro ASAI, Hideo MASHIMOTO, Shouichi SATO, Jun ARAKI, Michio OGAWA, Satoshi IKEI, Masao YOSHIDA, Katsuya INADA, Kenji TADOKORO

Publikováno v: Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases. 68(1)

The efficacy, safety and usefulness of murine anti-endotoxin monoclonal IgM antibody "E5, an intravenous dose of 2 mg/kg" were evaluated in 88 patients with suspected Gram-negative sepsis from 37 institutes in Japan. Out of these, 74 patients were ev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db9691b5d850be9a6bfb326f7ba142ea
https://pubmed.ncbi.nlm.nih.gov/8138682