Human blood vessel organoids reveal a critical role for CTGF in maintaining microvascular integrity

Autor: Sara G. Romeo, Ilaria Secco, Edoardo Schneider, Christina M. Reumiller, Celio X. C. Santos, Anna Zoccarato, Vishal Musale, Aman Pooni, Xiaoke Yin, Konstantinos Theofilatos, Silvia Cellone Trevelin, Lingfang Zeng, Giovanni E. Mann, Varun Pathak, Kevin Harkin, Alan W. Stitt, Reinhold J. Medina, Andriana Margariti, Manuel Mayr, Ajay M. Shah, Mauro Giacca, Anna Zampetaki

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)

Abstract The microvasculature plays a key role in tissue perfusion and exchange of gases and metabolites. In this study we use human blood vessel organoids (BVOs) as a model of the microvasculature. BVOs fully recapitulate key features of the human m

Externí odkaz: https://doaj.org/article/353954422197417aa51e7b271e88c1e2

SARS-CoV-2, myocardial injury and inflammation: insights from a large clinical and autopsy study

Autor: Marco Metra, Rossana Bussani, Alessia Paldino, Fulvio Silvestri, Serena Zacchigna, Chiara Collesi, Mauro Giacca, Marco Merlo, Matteo Dal Ferro, Ricardo Correa, Gianfranco Sinagra, Edoardo Schneider, Lorena Zentilin, Vincenzo Nuzzi

Publikováno v: Clinical Research in Cardiology

Objective Despite growing evidence about myocardial injury in hospitalized COronaVIrus Disease 2019 (COVID-19) patients, the mechanism behind this injury is only poorly understood and little is known about its association with SARS-CoV-2-mediated myo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e397c3f6b42223ff62d146225cc40885
https://doi.org/10.1007/s00392-021-01910-2

SARS-CoV-2 Spike protein activates TMEM16F-mediated platelet pro-coagulant activity

Autor: Ambra Cappelletto, Harriet E. Allan, Marilena Crescente, Edoardo Schneider, Rossana Bussani, Hashim Ali, Ilaria Secco, Simone Vodret, Roberto Simeone, Luca Mascaretti, Serena Zacchigna, Timothy D. Warner, Mauro Giacca

Publikováno v: Cappelletto, A, Allan, H E, Crescente, M, Schneider, E, Bussani, R, Ali, H, Secco, I, Vodret, S, Mascaretti, L, Zacchigna, S, Warner, T D, Giacca, M & Simeone, R 2022, ' SARS-CoV-2 Spike protein activates TMEM16F-mediated platelet pro-coagulant activity ', Frontiers in Cardiovascular Medicine .

BackgroundThrombosis of the lung micro-vasculature is a characteristic of COVID-19 disease, which is observed in large excess compared to other forms of acute respiratory distress syndrome and thus suggests a trigger for thrombosis endogenous to the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43a930feb76bb8ef34f8ab108782cddb
https://doi.org/10.1101/2021.12.14.472668

Drugs that inhibit TMEM16 proteins block SARS-CoV-2 Spike-induced syncytia

Autor: Hashim Ali, Ilaria Secco, Daniel H. Goldhill, Jose M. Jimenez-Guardeño, Luca Braga, Juan Burrone, Giorgia Rizzari, Guilherme Neves, Antonio Cannatà, Edoardo Schneider, Chiara Collesi, Mauro Giacca, Ajay M. Shah, Michael H. Malim, Rebecca Penn, Wendy S. Barclay, Elena Chiavacci, Daniele Arosio, Rossana Bussani, Ana Maria Ortega-Prieto

Publikováno v: Nature
Nature (Lond.) 594 (2021): 88–93. doi:10.1038/s41586-021-03491-6
info:cnr-pdr/source/autori:Braga L.; Ali H.; Secco I.; Chiavacci E.; Neves G.; Goldhill D.; Penn R.; Jimenez-Guardeno J.M.; Ortega-Prieto A.M.; Bussani R.; Cannata A.; Rizzari G.; Collesi C.; Schneider E.; Arosio D.; Shah A.M.; Barclay W.S.; Malim M.H.; Burrone J.; Giacca M./titolo:Drugs that inhibit TMEM16 proteins block SARS-CoV-2 spike-induced syncytia/doi:10.1038%2Fs41586-021-03491-6/rivista:Nature (Lond.)/anno:2021/pagina_da:88/pagina_a:93/intervallo_pagine:88–93/volume:594

COVID-19 is a disease with unique characteristics that include lung thrombosis1, frequent diarrhoea2, abnormal activation of the inflammatory response3 and rapid deterioration of lung function consistent with alveolar oedema4. The pathological substr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ee8ef2a9edf1c3b1df8e8a7186d90cf
http://hdl.handle.net/11368/2993737

Persistence of viral RNA, widespread thrombosis and abnormal cellular syncytia are hallmarks of COVID-19 lung pathology

Autor: Hashim Ali, Ilaria Secco, Luca Braga, Maria Concetta Volpe, Chiara Collesi, Serena Zacchigna, Giorgio Berlot, Fabrizio Zanconati, Andrea Colliva, Lorena Zentilin, Mauro Giacca, Rossana Bussani, Furio Silvestri, Edoardo Schneider

COVID-19 is a deadly pulmonary disease with unique clinical features. A thorough understanding of the molecular and histological correlates of the disease is still missing, especially because post-mortem analysis of COVID-19-affected organs has been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29b7930bbce31b00980fe2a68f6816d5