Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Edoardo Ratto"'
Autor:
Edoardo Ratto, S. Roy Chowdhury, Nora S. Siefert, Martin Schneider, Marten Wittmann, Dominic Helm, Wilhelm Palm
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
mTORC1 blocks lysosomal nutrient generation. Here, the authors show that mTORC1 inactivation triggers V-ATPase assembly, which rapidly initiates lysosomal acidification and degradation of protein contents throughout the lysosomal population.
Externí odkaz:
https://doaj.org/article/8559f72c4bbd46828666b8488f786076
Publikováno v:
Cell Stress, Vol 2, Iss 12, Pp 332-339 (2018)
Pancreatic cancer is the fourth most common cause of cancer-related mortality, with a dismal prognosis that has changed little over the past few decades. Despite extensive efforts in understanding the oncogenetics of this pathology, pancreatic cancer
Externí odkaz:
https://doaj.org/article/26bdcb8649744e229495b019718ca27e
Publikováno v:
Biomolecules, Vol 9, Iss 3, p 104 (2019)
Phosphorylation of inositol phospholipids by the family of phosphoinositide 3-kinases (PI3Ks) is crucial in controlling membrane lipid composition and regulating a wide range of intracellular processes, which include signal transduction and vesicular
Externí odkaz:
https://doaj.org/article/c435803c03bb42c7a78a77921f40ba2c
Autor:
Maria Chiara De Santis, Luca Gozzelino, Jean Piero Margaria, Andrea Costamagna, Edoardo Ratto, Federico Gulluni, Enza Di Gregorio, Erica Mina, Nicla Lorito, Marina Bacci, Rossano Lattanzio, Gianluca Sala, Paola Cappello, Francesco Novelli, Elisa Giovannetti, Caterina Vicentini, Silvia Andreani, Pietro Delfino, Vincenzo Corbo, Aldo Scarpa, Paolo Ettore Porporato, Andrea Morandi, Emilio Hirsch, Miriam Martini
Publikováno v:
Gut, 72(2), 360-371. BMJ Publishing Group
de Santis, M C, Gozzelino, L, Margaria, J P, Costamagna, A, Ratto, E, Gulluni, F, di Gregorio, E, Mina, E, Lorito, N, Bacci, M, Lattanzio, R, Sala, G, Cappello, P, Novelli, F, Giovannetti, E, Vicentini, C, Andreani, S, Delfino, P, Corbo, V, Scarpa, A, Porporato, P E, Morandi, A, Hirsch, E & Martini, M 2022, ' Lysosomal lipid switch sensitises to nutrient deprivation and mTOR targeting in pancreatic cancer ', Gut, vol. 72, no. 2, pp. 360-371 . https://doi.org/10.1136/gutjnl-2021-325117
de Santis, M C, Gozzelino, L, Margaria, J P, Costamagna, A, Ratto, E, Gulluni, F, di Gregorio, E, Mina, E, Lorito, N, Bacci, M, Lattanzio, R, Sala, G, Cappello, P, Novelli, F, Giovannetti, E, Vicentini, C, Andreani, S, Delfino, P, Corbo, V, Scarpa, A, Porporato, P E, Morandi, A, Hirsch, E & Martini, M 2022, ' Lysosomal lipid switch sensitises to nutrient deprivation and mTOR targeting in pancreatic cancer ', Gut, vol. 72, no. 2, pp. 360-371 . https://doi.org/10.1136/gutjnl-2021-325117
ObjectivePancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with limited therapeutic options. However, metabolic adaptation to the harsh PDAC environment can expose liabilities useful for therapy. Targeting the key metabolic regulator m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a773704449eb1efc62289fcb4007343a
http://hdl.handle.net/2318/1861832
http://hdl.handle.net/2318/1861832
Publikováno v:
Cell Stress, Vol 2, Iss 12, Pp 332-339 (2018)
Cell Stress
Cell Stress
Pancreatic cancer is the fourth most common cause of cancer-related mortality, with a dismal prognosis that has changed little over the past few decades. Despite extensive efforts in understanding the oncogenetics of this pathology, pancreatic cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63f821a6d916df9604aaff7f24599e64
http://www.cell-stress.com/researcharticles/2018a-derle-cell-stress/
http://www.cell-stress.com/researcharticles/2018a-derle-cell-stress/
Publikováno v:
Biomolecules
Biomolecules, Vol 9, Iss 3, p 104 (2019)
Biomolecules, Vol 9, Iss 3, p 104 (2019)
Phosphorylation of inositol phospholipids by the family of phosphoinositide 3-kinases (PI3Ks) is crucial in controlling membrane lipid composition and regulating a wide range of intracellular processes, which include signal transduction and vesicular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33ffd502515f7c5df80d854f20b40480
https://pubmed.ncbi.nlm.nih.gov/30884740
https://pubmed.ncbi.nlm.nih.gov/30884740
Autor:
Giorgio R. Merlo, Monika Pema, Maria Chiara De Santis, Marco Chiaravalli, Carlo Cosimo Campa, Stefan Somlo, Andrea Ranghino, David Perez-Morga, Daniel Monteyne, Jean Piero Margaria, Emilio Hirsch, Alessandra Boletta, Edoardo Ratto, Federico Gulluni, Irene Franco
Publikováno v:
Journal of the American Society of Nephrology. 27:1135-1144
Signaling from the primary cilium regulates kidney tubule development and cyst formation. However, the mechanism controlling targeting of ciliary components necessary for cilium morphogenesis and signaling is largely unknown. Here, we studied the fun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d02dbaec3e24dacf20ab9a40feb0113
https://doi.org/10.1681/asn.2014100967
https://doi.org/10.1681/asn.2014100967
Publikováno v:
ESMO Open. 3:A2-A3
Introduction Pancreatic Ductal Adenocarcinoma (PDAC) is the most lethal cancer across the world, with incidence equaling mortality. The lack of progress in early diagnosis and effective therapies are the main reasons why improvements in PDAC death ra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b41e5320438c3e4e00474d6e370fb65
https://doi.org/10.1136/esmoopen-2018-eacr25.5
https://doi.org/10.1136/esmoopen-2018-eacr25.5