Radiotherapy plus pembrolizumab for advanced urothelial carcinoma: results from the ARON-2 real-world study

Autor: Mimma Rizzo, Andrey Soares, Enrique Grande, Aristotelis Bamias, Ray Manneh Kopp, Edoardo Lenci, Thomas Buttner, Samer Salah, Francesco Grillone, Icaro Thiago de Carvalho, Jose Carlos Tapia, Calogero Gucciardino, Alvaro Pinto, Alessia Mennitto, Halima Abahssain, Pasquale Rescigno, Zin Myint, Hideki Takeshita, Gian Paolo Spinelli, Lazar Popovic, Maria Giuseppa Vitale, Ondrej Fiala, Patrizia Giannatempo, Roubini Zakopoulou, Francesco Carrozza, Francesco Massari, Fernando Sabino Marques Monteiro, Maria Paola Pace, Massimo Giannini, Giandomenico Roviello, Camillo Porta, Nicola Battelli, Ravindran Kanesvaran, Matteo Santoni

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)

Abstract The addition of metastasis-directed radiotherapy (MDRT) to immunotherapy in patients with advanced urothelial carcinoma (aUC) has shown promising results. We report the real-world data from the ARON-2 study (NCT05290038) on the impact of con

Externí odkaz: https://doaj.org/article/7c7f88d7c9824bbc938bd6730c370b0e

Lynch syndrome-associated lung cancer: pitfalls of an immunotherapy-based treatment strategy in an unusual tumor type

Autor: Elena Maccaroni, Edoardo Lenci, Veronica Agostinelli, Valeria Cognigni, Riccardo Giampieri, Paola Mazzanti, Marzia Di Pietro Paolo, Francesca Bianchi, Cristiana Brugiati, Laura Belvederesi, Silvia Pagliaretta, Alessandra Mandolesi, Marina Scarpelli, Alberto Murrone, Francesca Morgese, Zelmira Ballatore, Rossana Berardi

Publikováno v: Exploration of Targeted Anti-tumor Therapy, Vol 2, Iss 3 (2021)

Lynch syndrome is a hereditary cancer predisposition syndrome caused by germline alterations in mismatch repair (MMR) genes leading to increased risk of colon cancer as well as other cancer types. Non-small cell lung cancer (NSCLC) is not among typic

Externí odkaz: https://doaj.org/article/3e07c63eb0d049aebd590237bbb093ac

BRCA mutations and gastrointestinal cancers: When to expect the unexpected?

Autor: Francesca Bianchi, Elisa Ambrosini, Riccardo Giampieri, C. Brugiati, Silvia Pagliaretta, Laura Scortichini, Elena Maccaroni, Edoardo Lenci, L. Belvederesi, Rossana Berardi

Publikováno v: World Journal of Clinical Oncology

BRCA1/2 pathogenic variants are widely known as major risk factors mainly for breast and ovarian cancer, while their role in gastrointestinal (GI) malignancies such as colorectal cancer (CRC), gastric cancer and oesophageal cancer (OeC) is still not

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b4a5a79252ff63b9973214116e80b60
http://europepmc.org/articles/PMC8317649

Beyond Microsatellite Instability: Evolving Strategies Integrating Immunotherapy for Microsatellite Stable Colorectal Cancer

Autor: Alessio Lupi, Edoardo Lenci, Federica Pecci, Rossana Berardi, Riccardo Giampieri, Alessandro Bittoni, Sonia Crocetti, Enrica Giglio, Luca Cantini

Publikováno v: Current Treatment Options in Oncology

Opinion statementAdvanced colorectal cancer (CRC) is a heterogeneous disease, characterized by several subtypes with distinctive genetic and epigenetic patterns. During the last years, immune checkpoint inhibitors (ICIs) have revamped the standard of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63a2a80241c5235b5f0f619e00eff1d1
https://doi.org/10.1007/s11864-021-00870-z

The Gustave Roussy Immune (GRIm)-Score Variation Is an Early-on-Treatment Biomarker of Outcome in Advanced Non-Small Cell Lung Cancer (NSCLC) Patients Treated with First-Line Pembrolizumab

Autor: Federica Pecci, Alessio Cortellini, Valeria Cognigni, Silvia Rinaldi, Andrea Caglio, Nicoletta Ranallo, Alessio Lupi, Veronica Agostinelli, Edoardo Lenci, Corrado Ficorella, Francesco Paoloni, Rossana Berardi, Sophie Aerts, Rita Chiari, Joachim G.J.V. Aerts, Massimo Di Maio, Giulia Mentrasti, Linda Nicolardi, Luca Cantini, Anne-Marie C. Dingemans

Publikováno v: Journal of Clinical Medicine, Vol 10, Iss 1005, p 1005 (2021)
Journal of Clinical Medicine
Journal of Clinical Medicine, 10(5):1005, 1-14. Multidisciplinary Digital Publishing Institute (MDPI)
Volume 10
Issue 5

Background: The Gustave Roussy Immune (GRIm)-Score takes into account neutrophil-to-lymphocyte ratio (NLR), serum albumin concentration and lactate dehydrogenase (LDH) and its prognostic value has been investigated in patients treated with immune che

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2664c30fac510e79b9c8e5855e518094
https://www.mdpi.com/2077-0383/10/5/1005