Zobrazeno 1 - 10
of 190
pro vyhledávání: '"Edna Cukierman"'
Autor:
Daniel C. Stewart, Becky K. Brisson, Bassil Dekky, Ashton C. Berger, William Yen, Elizabeth A. Mauldin, Claudia Loebel, Deborah Gillette, Charles-Antoine Assenmacher, Corisa Quincey, Darko Stefanovski, Massimo Cristofanilli, Edna Cukierman, Jason A. Burdick, Virginia F. Borges, Susan W. Volk
Publikováno v:
npj Breast Cancer, Vol 10, Iss 1, Pp 1-19 (2024)
Abstract Collagen plays a critical role in regulating breast cancer progression and therapeutic resistance. An improved understanding of both the features and drivers of tumor-permissive and -restrictive collagen matrices are critical to improve prog
Externí odkaz:
https://doaj.org/article/1f8570802070429fb59316d40cdbc510
Autor:
Jason S. Wasserman, Holly Fowle, Rumesa Hashmi, Diba Atar, Kishan R. Patel, Amir Yarmahmoodi, Alexander W. Macfarlane, Yinfei Tan, Edna Cukierman, Bojana Gligorijevic, Adam Karami, Kelly A. Whelan, Kerry S. Campbell, Xavier Graña
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract Prostate cancer (PCa) is the most common cancer diagnosed in men worldwide and was the second leading cause of cancer-related deaths in US males in 2022. Prostate cancer also represents the second highest cancer mortality disparity between n
Externí odkaz:
https://doaj.org/article/398f3efd1a784589babef813afa2a8f6
Autor:
Matthew Zibelman, Alexander W. MacFarlane, Kimberly Costello, Thomas McGowan, John O’Neill, Rutika Kokate, Hossein Borghaei, Crystal S. Denlinger, Efrat Dotan, Daniel M. Geynisman, Angela Jain, Lainie Martin, Elias Obeid, Karthik Devarajan, Karen Ruth, R. Katherine Alpaugh, Essel Al-Saleem Dulaimi, Edna Cukierman, Margret Einarson, Kerry S. Campbell, Elizabeth R. Plimack
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract This phase I, dose-escalation trial evaluates the safety of combining interferon-gamma (IFN-γ) and nivolumab in patients with metastatic solid tumors. Twenty-six patients are treated in four cohorts assessing increasing doses of IFN-γ with
Externí odkaz:
https://doaj.org/article/ce3d085e03764e52a9561fa23ca9cb9a
Autor:
Tiffany Luong, Edna Cukierman
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-17 (2022)
Abstract Background Less than 11% of pancreatic cancer patients survive 5-years post-diagnosis. The unique biology of pancreatic cancer includes a significant expansion of its desmoplastic tumor microenvironment, wherein cancer-associated fibroblasts
Externí odkaz:
https://doaj.org/article/9474d4052ac345448cbd2d09ff3dfa01
Autor:
Claudia Capparelli, Timothy J. Purwin, McKenna Glasheen, Signe Caksa, Manoela Tiago, Nicole Wilski, Danielle Pomante, Sheera Rosenbaum, Mai Q. Nguyen, Weijia Cai, Janusz Franco-Barraza, Richard Zheng, Gaurav Kumar, Inna Chervoneva, Ayako Shimada, Vito W. Rebecca, Adam E. Snook, Kim Hookim, Xiaowei Xu, Edna Cukierman, Meenhard Herlyn, Andrew E. Aplin
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Mechanisms underlying tumor cell plasticity remain poorly understood. Here, the authors show the presence of a dormant-invasive SOX10- subpopulation in cutaneous melanoma that can be targeted by cIAP1/2 inhibitors.
Externí odkaz:
https://doaj.org/article/59cac3fded2d4f39825e28a5697d2477
Publikováno v:
BME Frontiers, Vol 4 (2023)
We need novel strategies to target the complexity of cancer and, particularly, of metastatic disease. As an example of this complexity, certain tissues are particularly hospitable environments for metastases, whereas others do not contain fertile mic
Externí odkaz:
https://doaj.org/article/ede2b7ab21dd4589900c6c096668c983
Autor:
Caitlin E. Jones, Anisha M. Hammer, YouJin Cho, Gina M. Sizemore, Edna Cukierman, Lisa D. Yee, Samir N. Ghadiali, Michael C. Ostrowski, Jennifer L. Leight
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 21, Iss 1, Pp 132-145 (2019)
The organization of the extracellular matrix has a profound impact on cancer development and progression. The matrix becomes aligned throughout tumor progression, providing “highways” for tumor cell invasion. Aligned matrix is associated with bre
Externí odkaz:
https://doaj.org/article/fb890cfa8be04e6385066d38ace09c7d
Autor:
Janusz Franco-Barraza, Ralph Francescone, Tiffany Luong, Neelima Shah, Raj Madhani, Gil Cukierman, Essel Dulaimi, Karthik Devarajan, Brian L Egleston, Emmanuelle Nicolas, R Katherine Alpaugh, Ruchi Malik, Robert G Uzzo, John P Hoffman, Erica A Golemis, Edna Cukierman
Publikováno v:
eLife, Vol 6 (2017)
Desmoplasia, a fibrotic mass including cancer-associated fibroblasts (CAFs) and self-sustaining extracellular matrix (D-ECM), is a puzzling feature of pancreatic ductal adenocarcinoma (PDACs). Conflicting studies have identified tumor-restricting and
Externí odkaz:
https://doaj.org/article/87d0f3b4b2cc483eb0328f8d331585cb
Autor:
Daniel E. Bassi, Jirong Zhang, Jonathan Cenna, Samuel Litwin, Edna Cukierman, Andres J.P. Klein-Szanto
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 12, Iss 7, Pp 516-526 (2010)
PACE4 is a proprotein convertase (PC) responsible for cleaving and activating proteins that contribute to enhance tumor progression. PACE4 overexpression significantly increased the susceptibility to carcinogenesis, leading to enhanced tumor cell pro
Externí odkaz:
https://doaj.org/article/6ffe4e26b35b4428ad904ff51f072ec2
Autor:
Maria Håkanson, Stefan Kobel, Matthias P Lutolf, Marcus Textor, Edna Cukierman, Mirren Charnley
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e40141 (2012)
Increasing evidence shows that the cancer microenvironment affects both tumorigenesis and the response of cancer to drug treatment. Therefore in vitro models that selectively reflect characteristics of the in vivo environment are greatly needed. Curr
Externí odkaz:
https://doaj.org/article/7bcaa9bbe7524284a4d7872d41c7d024