Zobrazeno 1 - 10
of 184
pro vyhledávání: '"Edna C Hardeman"'
Autor:
James Rae, Charles Ferguson, Nicholas Ariotti, Richard I Webb, Han-Hao Cheng, James L Mead, James D Riches, Dominic JB Hunter, Nick Martel, Joanne Baltos, Arthur Christopoulos, Nicole S Bryce, Maria Lastra Cagigas, Sachini Fonseka, Marcel E Sayre, Edna C Hardeman, Peter W Gunning, Yann Gambin, Thomas E Hall, Robert G Parton
Publikováno v:
eLife, Vol 10 (2021)
Genetic tags allow rapid localization of tagged proteins in cells and tissues. APEX, an ascorbate peroxidase, has proven to be one of the most versatile and robust genetic tags for ultrastructural localization by electron microscopy (EM). Here, we de
Externí odkaz:
https://doaj.org/article/de648e408e3f416f9efd1c844760a3c8
Autor:
Peter W Gunning, Edna C Hardeman
Publikováno v:
eLife, Vol 7 (2018)
The differences between β- and γ-actin are deeper than those between the amino acid sequences of these two proteins.
Externí odkaz:
https://doaj.org/article/2e3a72dacb4648b48c7b0d45c0c79f28
Autor:
Mark A Appaduray, Andrius Masedunskas, Nicole S Bryce, Christine A Lucas, Sean C Warren, Paul Timpson, Jeffrey H Stear, Peter W Gunning, Edna C Hardeman
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0168203 (2016)
The actin cytoskeleton is a dynamic network of filaments that is involved in virtually every cellular process. Most actin filaments in metazoa exist as a co-polymer of actin and tropomyosin (Tpm) and the function of an actin filament is primarily def
Externí odkaz:
https://doaj.org/article/e58eb5c67b98417db2dbd4270007b02b
Autor:
Iman Jalilian, Celine Heu, Hong Cheng, Hannah Freittag, Melissa Desouza, Justine R Stehn, Nicole S Bryce, Renee M Whan, Edna C Hardeman, Thomas Fath, Galina Schevzov, Peter W Gunning
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0126214 (2015)
The actin cytoskeleton is the primary polymer system within cells responsible for regulating cellular stiffness. While various actin binding proteins regulate the organization and dynamics of the actin cytoskeleton, the proteins responsible for regul
Externí odkaz:
https://doaj.org/article/c03859392a5f4daa968f0b45f919ec94
Autor:
Charlotte Gineste, Coen Ottenheijm, Yann Le Fur, Sébastien Banzet, Emilie Pecchi, Christophe Vilmen, Patrick J Cozzone, Nathalie Koulmann, Edna C Hardeman, David Bendahan, Julien Gondin
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e109066 (2014)
Nemaline myopathy is the most common disease entity among non-dystrophic skeletal muscle congenital diseases. The first disease causing mutation (Met9Arg) was identified in the gene encoding α-tropomyosin slow gene (TPM3). Considering the conflictin
Externí odkaz:
https://doaj.org/article/b32b4c15c7ce415da68396d55d8cb58a
Autor:
Charlotte Gineste, Yann Le Fur, Christophe Vilmen, Arnaud Le Troter, Emilie Pecchi, Patrick J Cozzone, Edna C Hardeman, David Bendahan, Julien Gondin
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61517 (2013)
Nemaline myopathy (NM) is the most common disease entity among non-dystrophic skeletal muscle congenital diseases. Mutations in the skeletal muscle α-actin gene (ACTA1) account for ∼25% of all NM cases and are the most frequent cause of severe for
Externí odkaz:
https://doaj.org/article/15dfb273180c41c6a596155050b68a20
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e49283 (2012)
GTF2IRD1 is one of the genes implicated in Williams-Beuren syndrome, a disease caused by haploinsufficiency of certain dosage-sensitive genes within a hemizygous microdeletion of chromosome 7. GTF2IRD1 is a prime candidate for some of the major featu
Externí odkaz:
https://doaj.org/article/cc747b992ae44ab4931d6407dc917a2f
Autor:
Peter W. Gunning, Edna C. Hardeman, Justine Stehn, Timothy P. Cripe, Vera B. Dugina, Irina B. Alieva, Michael Carnell, Nicole S. Bryce, Xing Xu, Ashleigh Swain, Jeffrey H. Stear, Yao Wang
Representative images of spindle phenotypes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::613a61d3c5b2a62ddc5792466dbc07e7
https://doi.org/10.1158/1541-7786.22517922.v1
https://doi.org/10.1158/1541-7786.22517922.v1
Autor:
Timothy P. Cripe, Peter W. Gunning, Edna C. Hardeman, Vera B. Dugina, Irina B. Alieva, Jun Zeng, Herbert Treutlein, Nina Kloss, David W. Eaves, Brooke A. Nartker, David Brown, Andrew Heaton, Eleanor Eiffe, Jeff Hook, Duo Chen, Ashleigh Swain, Justine R. Stehn, Mark A. Currier
Supplementary Materials and Methods; Figure S1. Western blot of tropomyosin isoforms in neuroblastoma cells used in this project; Figure S2. Effect of combining tropomyosin and microtubule inhibitors on cell growth; Figure S3. A, B, Effect of TR100 o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbcb48ec37c05169fe0dec295c0792c7
https://doi.org/10.1158/1535-7163.22507779.v1
https://doi.org/10.1158/1535-7163.22507779.v1
Autor:
Timothy P. Cripe, Peter W. Gunning, Edna C. Hardeman, Vera B. Dugina, Irina B. Alieva, Jun Zeng, Herbert Treutlein, Nina Kloss, David W. Eaves, Brooke A. Nartker, David Brown, Andrew Heaton, Eleanor Eiffe, Jeff Hook, Duo Chen, Ashleigh Swain, Justine R. Stehn, Mark A. Currier
Actin filaments, with their associated tropomyosin polymers, and microtubules are dynamic cytoskeletal systems regulating numerous cell functions. While antimicrotubule drugs are well-established, antiactin drugs have been more elusive. We previously
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::784455f96f8547a82cee2cae5124a729
https://doi.org/10.1158/1535-7163.c.6538785.v1
https://doi.org/10.1158/1535-7163.c.6538785.v1