Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Edmund-J D Lee"'
Publikováno v:
Annals of the Academy of Medicine, Singapore. 36:394-398
Introduction: Long QT syndrome (LQTS), an inherited cardiac arrhythmia, is a disorder of ventricular repolarisation characterised by electrocardiographic abnormalities and the onset of torsades de pointes leading to syncope and sudden death. Genetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::599feb3fac246f3ba90e90171f07c281
https://doi.org/10.47102/annals-acadmedsg.v36n6p394
https://doi.org/10.47102/annals-acadmedsg.v36n6p394
Autor:
Onkar Singh, Joanne Lim, Xiangai Chen, Edmund-J D Lee, Eng Huat Tan, Balram Chowbay, Sin Chi Chew
Publikováno v:
European journal of clinical pharmacology. 70(2)
This exploratory study was aimed at elucidating the pharmacogenetics of regulatory nuclear receptors (PXR, CAR, RXRα and HNF4α) and their implications on docetaxel pharmacokinetics and pharmacodynamics in local Chinese nasopharyngeal cancer patient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d1ecb33a78f5d023c433222d35d06b6
https://pubmed.ncbi.nlm.nih.gov/24193570
https://pubmed.ncbi.nlm.nih.gov/24193570
Autor:
Sin Chi, Chew, Edwin, Sandanaraj, Onkar, Singh, Xiangai, Chen, Eng Huat, Tan, Wan Teck, Lim, Edmund J D, Lee, Balram, Chowbay
Publikováno v:
British journal of clinical pharmacology. 73(4)
SLCO1B3 is an influx transporter located at the hepatocyte basolateral membrane and it is involved in the uptake of a broad range of drug substrates including docetaxel. The pharmacogenetics of SLCO1B3 is not well characterized and previous in vivo a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::339ce03cbafda4a3c85fc043b92392cd
https://pubmed.ncbi.nlm.nih.gov/21995462
https://pubmed.ncbi.nlm.nih.gov/21995462
Publikováno v:
British journal of clinical pharmacology. 56(1)
To investigate the frequency of the single nucleotide polymorphism C3435T in exon 26 of the MDR1 gene in Asians and to determine the functional significance of this SNP with the clinical pharmacokinetics of oral cyclosporin (Neoral) in 10 stable hear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::45a6ef22853ce60aa1442d65a802d20f
https://pubmed.ncbi.nlm.nih.gov/12848778
https://pubmed.ncbi.nlm.nih.gov/12848778
Publikováno v:
Oncology reports. 10(3)
Diarrhoea is the major dose-limiting toxicity of irinotecan hydrochloride (CPT-11) in the clinical setting. This study was designed to evaluate the effects of different pharmacological agents in the modulation of CPT-11 induced diarrhoea in Sprague-D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::90379a0b5b06a25b67aee9e545919180
https://pubmed.ncbi.nlm.nih.gov/12684653
https://pubmed.ncbi.nlm.nih.gov/12684653