NCK Associated Protein 1 Modulated by miRNA‐214 Determines Vascular Smooth Muscle Cell Migration, Proliferation, and Neointima Hyperplasia

Autor: Tayyab Adeel Afzal, Le Anh Luong, Dan Chen, Cheng Zhang, Feng Yang, Qishan Chen, Weiwei An, Edmund Wilkes, Kenta Yashiro, Pedro R. Cutillas, Li Zhang, Qingzhong Xiao

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 5, Iss 12 (2016)

BackgroundMicroRNA miR‐214 has been implicated in many biological cellular functions, but the impact of miR‐214 and its target genes on vascular smooth muscle cell (VSMC) proliferation, migration, and neointima smooth muscle cell hyperplasia is u

Externí odkaz: https://doaj.org/article/c097f5e8833a422f8ca7136bf9b42aa0

Liver Activation of Hepatocellular Nuclear Factor-4α by Small Activating RNA Rescues Dyslipidemia and Improves Metabolic Profile

Autor: Ling Peng, Nikos Kostomitsopoulos, Stephanie Dorman, Edmund Wilkes, Joanna Nicholls, Isabella Reccia, Katherine Czysz, John J. Rossi, Vikash Reebye, Pål Sætrom, Nagy A. Habib, Simona Ciriello, Hong-Shiee Lai, Donald A. Tomalia, Pedro R. Cutillas, Robert Habib, Kai-Wen Huang

Publikováno v: Molecular Therapy-Nucleic Acids
Molecular Therapy-Nucleic Acids, Nature Publishing Group, 2020, 19, pp.361-370. ⟨10.1016/j.omtn.2019.10.044⟩
Molecular Therapy-Nucleic Acids, Elsevier, 2020, 19, pp.361-370. ⟨10.1016/j.omtn.2019.10.044⟩
Molecular Therapy-Nucleic Acids, 2020, 19, pp.361-370. ⟨10.1016/j.omtn.2019.10.044⟩
Molecular Therapy. Nucleic Acids

International audience; Non-alcoholic fatty liver disease (NAFLD) culminates in insulin resistance and metabolic syndrome. Because there are no approved pharmacological treatment agents for non-alcoholic steatohepatitis (NASH) and NAFLD, different si

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88e7732f7c883d8d12f47841d498fcfc
https://hal.archives-ouvertes.fr/hal-02480317

Abstract P3-06-02: Characterization of resistance to the selective CDK4/6 inhibitor palbociclib in ER positive breast cancer

Autor: Edmund Wilkes, A Shia, C Lenihan, Peter Schmid, Pedro R. Cutillas, K Bouchekioua-Bouzaghou, Pedro Casado-Izquierdo

Publikováno v: Cancer Research. 76:P3-06

Background: Dysregulation of the cyclin D-CDK4/6-Rb axis occurs in a substantial proportion of ER-positive (ER+) breast cancers and has been linked with endocrine resistance. Adding the CDK4/6 inhibitor palbociclib to endocrine treatment has led to a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::66540999d6def01c30e83648125980bc
https://doi.org/10.1158/1538-7445.sabcs15-p3-06-02

Proteomic and genomic integration identifies kinase and differentiation determinants of kinase inhibitor sensitivity in leukemia cells

Autor: Sameena Iqbal, John G. Gribben, Steven Best, Rebecca Pike, Nicholas Lea, Jude Fitzgibbon, S Marfa, Farideh Miraki-Moud, Pedro R. Cutillas, Pedro Casado, Ana Rio-Machin, MM Hadi, Rajeeve, Edmund Wilkes

Publikováno v: Leukemia

Proteomic and genomic integration identifies kinase and differentiation determinants of kinase inhibitor sensitivity in leukemia cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b61c9dce86cd487cef2478530239338
https://doi.org/10.1038/leu.2017.349

Label-Free Phosphoproteomic Approach for Kinase Signaling Analysis

Autor: Edmund Wilkes, Pedro R. Cutillas

Publikováno v: Methods in Molecular Biology ISBN: 9781493971527

Phosphoproteomics is a powerful platform for the unbiased profiling of kinase-driven signaling pathways. Quantitation of phosphorylation can be performed by means of either labeling or label-free mass spectrometry (MS) methods. Because of their simpl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b7bcd544a14a09dcedef091a6a4491bc
https://doi.org/10.1007/978-1-4939-7154-1_13