Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Edmund Sybertz"'
Autor:
Edmund Sybertz, Dimitri Krainc
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 10, Pp 1996-2003 (2014)
Therapeutic efforts in neurodegenerative diseases have been very challenging, particularly due to a lack of validated and mechanism-based therapeutic targets and biomarkers. The basic idea underlying the novel therapeutic approaches reviewed here is
Externí odkaz:
https://doaj.org/article/4de44c7236f9493a9b36da7e8a17d03a
Autor:
Dimitri Krainc, Edmund Sybertz
Publikováno v:
Journal of Lipid Research, Vol 55, Iss 10, Pp 1996-2003 (2014)
Therapeutic efforts in neurodegenerative diseases have been very challenging, particularly due to a lack of validated and mechanism-based therapeutic targets and biomarkers. The basic idea underlying the novel therapeutic approaches reviewed here is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6200369a8ca28b7406ec9c0559653f05
https://doi.org/10.1194/jlr.r047381
https://doi.org/10.1194/jlr.r047381
Autor:
Edmund Sybertz, Clifford L. Hendrick, Nigel Yarlett, Robert H. Barker, Aixa Rodriguez, Donna Rattendi, Cyrus J. Bacchi, Bradford H. Hirth
Publikováno v:
Antimicrobial Agents and Chemotherapy. 53:3269-3272
Genzyme 644131, 8-methyl-5′-{[( Z )-4-aminobut-2-enyl](methylamino)}adenosine, is an analog of the enzyme activated S -adenosylmethionine decarboxylase (AdoMetDC) inhibitor and the trypanocidal agent MDL-7381, 5-{[( Z )-4-aminobut-2-enyl](methylami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7538281a509354bc75fd7090106a34b0
https://doi.org/10.1128/aac.00076-09
https://doi.org/10.1128/aac.00076-09
Autor:
Hanlan Liu, Margaret A. Phillips, Erin K. Willert, Yibin Xiang, Jeffrey D. Klinger, Bakela Nare, Bradford H. Hirth, Amarjit Nijjar, Cassandra Celatka, Edmund Sybertz, Robert H. Barker
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:2916-2919
Modification of the structure of trypanosomal AdoMetDC inhibitor 1 (MDL73811) resulted in the identification of a new inhibitor 7a, which features a methyl substituent at the 8-position. Compound 7a exhibits improved potencies against both the trypan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4d03fcaf297b21c70c293f0de3a8d8b
https://doi.org/10.1016/j.bmcl.2009.04.096
https://doi.org/10.1016/j.bmcl.2009.04.096
Autor:
Erin K. Willert, Yibin Xiang, Jeffrey D. Klinger, Aixa Rodriguez, Edmund Sybertz, Nigel Yarlett, Margaret A. Phillips, Richard Fitzpatrick, Hanlan Liu, Cyrus J. Bacchi, Robert H. Barker, Cassandra Celatka, Bradford H. Hirth, Marcel Kaiser
Publikováno v:
Antimicrobial Agents and Chemotherapy. 53:2052-2058
Trypanosomiasis remains a significant disease across the sub-Saharan African continent, with 50,000 to 70,000 individuals infected. The utility of current therapies is limited by issues of toxicity and the need to administer compounds intravenously.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ca679f201bc7ee1af7ac4f2a8ef0b28
https://doi.org/10.1128/aac.01674-08
https://doi.org/10.1128/aac.01674-08
Autor:
María Belén Jiménez-Díaz, Robert H. Barker, Iñigo Angulo-Barturen, Edmund Sybertz, Petros Papastogiannidis, Renato Skerlj, Michael Booker, Thomas O'Shea, Amar Bir Singh Sidhu, Joseph F. Cortese, Martin Kramer, Cecilia M. Bastos, Sergio Wittlin, Cassandra Celatka, Benito Munoz
Inhibition of dihydroorotate dehydrogenase (DHODH) for P. falciparum potentially represents a new treatment option for malaria, since DHODH catalyzes the rate-limiting step in the pyrimidine biosynthetic pathway and P. falciparum is unable to salvage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fb1aa7469cd8757c5d562337bf6318e
https://europepmc.org/articles/PMC4018051/
https://europepmc.org/articles/PMC4018051/
Autor:
Jose E. Guerrero-Bravo, Santiago Ferrer, Thomas O'Shea, Chris J. Janse, Noemi Magan, Keila N. Crespo-Llado, María Belén Jiménez-Díaz, Shahid M. Khan, Robert H. Barker, Jeffrey D. Klinger, Erin Tyndall, Ralph Mazitschek, Dyann F. Wirth, Amar Bir Singh Sidhu, Bradley I. Coleman, Vanesa Gomez, Jon Clardy, Manoj T. Duraisingh, Edmund Sybertz, Roger C. Wiegand, Cassandra Celatka, Iñigo Angulo-Barturen, Mark Bree, Sameer Urgaonkar, Mikaela Levine, Hanlan Liu, Mandy Cromwell, Adelfa E. Serrano, Ian Bathurst, Petros Papastogiannidis, Edward R. Lee, María Santos Martínez, Benito Munoz, Sergio Wittlin, Jing-wen Lin, Joseph F. Cortese, Renato Skerlj
Publikováno v:
Antimicrobial Agents and Chemotherapy, 55(6), 2612-2622
This study characterizes aminoindole molecules that are analogs of Genz-644442. Genz-644442 was identified as a hit in a screen of ∼70,000 compounds in the Broad Institute's small-molecule library and the ICCB-L compound collection at Harvard Medic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6fbde66a506d81a8bd5720aa4a9d64d
https://doi.org/10.1128/aac.01714-10
https://doi.org/10.1128/aac.01714-10
Autor:
Nicholas S. Hill, Oscar E. Guevara, Edmund Sybertz, Rod R. Warburton, Tiegang Liu, Yiban Xiang
Publikováno v:
C61. PULMONARY HYPERTENSION: EXPERIMENTAL MODELS II.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::904097c79aab8657ea66189f1e24906e
https://doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a4969
https://doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a4969