Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Edmund M. Harrington"'
Autor:
James J. Kowalczyk, Ana Maria Garcia, Michael D. Lewis, Sharon L. Pinnow, Edmund M. Harrington, Karen Ackermann
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 4:2775-2780
Compounds in which cysteine and methionine have been linked by amino acids replacing the A1A2 portion of the CA1A2X box template inhibit farnesyl and geranylgeranyl transferases. The expected specificity for FTase over GGTase I is observed. A variety
Autor:
Ana Maria Garcia, Edmund M. Harrington, Michael D. Lewis, Karen Ackermann, Xiaoning C. Sheng, Hu Yang
Publikováno v:
ChemInform. 30
Autor:
and Ana Maria Garcia, Michael D. Lewis, Edmund M. Harrington, Hu Yang, Xiaoning C. Sheng, Karen Ackermann
Publikováno v:
The Journal of organic chemistry. 64(1)
Syntheses of the potent sulfur-containing tetrapeptide mimetic farnesyl transferase inhibitors B956 (22) and B957 (23) are described. The two double bonds in 22 and 23 were constructed by application of iterative NHK and cuprate S(N)2' reactions. Nor
Autor:
Luc J. Farmer, Mark W. Ledeboer, Thomas Hoock, MichaelJ. Arnost, Randy S. Bethiel, Youssef L. Bennani, James J. Black, Christopher L. Brummel, Ananthsrinivas Chakilam, Warren A. Dorsch, Bin Fan, JohnE. Cochran, Summer Halas, Edmund M. Harrington, JamesK. Hogan, David Howe, Hui Huang, DylanH. Jacobs, Leena M. Laitinen, Shengkai Liao
Publikováno v:
Journal of Medicinal Chemistry; Sep2015, Vol. 58 Issue 18, p7195-7216, 22p