Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Edmund K. LeGrand"'
Publikováno v:
Evolution, Medicine, and Public Health. 9:26-35
Although fever is one of the main presenting symptoms of COVID-19 infection, little public attention has been given to fever as an evolved defense. Fever, the regulated increase in the body temperature, is part of the evolved systemic reaction to inf
Autor:
Edmund K. LeGrand, Joe Alcock
Publikováno v:
The Quarterly Review of Biology. 87:3-18
The acutephase response (APR) is a systemic response to severe trauma, infection, and cancer, although many of the numerous cytokine-mediated components of the APR are incompletely understood. Some of these components, such as fever, reduced availabi
Autor:
Ling Lin, Chaozhong Cai, Christopher M. Flores, Timothy P Coogan, Edmund K. LeGrand, Ellen E. Codd, Raymond W. Colburn, Angelique Leone, Charles Y. Wang, Mcdonnell Mark E, Scott L. Dax, Michael R. Brandt, Stewart Bryant, Bart DeCorte, James J. McNally, John R. Mabus, Sui-Po Zhang, John R. Carson, Michael Kemmerer, Dennis J. Stone, James M Lenhard, Michael K. McMillian, Kristen M. Chevalier, Judith Baker
Publikováno v:
Toxicological Sciences. 117:493-504
The unexpected observation of a hyperglycemic effect of some tricycle-based delta opioid receptor (DOR) agonists led to a series of studies to better understand the finding. Single administration of two novel tricyclic DOR agonists dose dependently e
Autor:
Edmund K. LeGrand, Judy Day
Publikováno v:
Journal of theoretical biology. 367
The immune brinksmanship conceptual model postulates that many of the non-specific stressful components of the acute-phase response (e.g. fever, loss of appetite, iron and zinc sequestration) are host-derived systemic stressors used with the "hope" t
Autor:
Edmund K. LeGrand
Publikováno v:
Drug Development Research. 52:439-445
The rapidly expanding technologies involving chemical synthesis and screening, genomics, and bioinformatics are leading to the point where every gene product can be modulated as a therapeutic target. Thus, pharmaceuticals increasingly offer the poten
Autor:
Edmund K. LeGrand
Publikováno v:
Perspectives in Biology and Medicine. 44:509-521
The benefits of apoptosis in the removal of unnecessary, damaged, or dangerous cells are dependent on the altruism resulting from the absence of genetic conflict between genes in cells. However, this altruism can be exploited by self-promoting or ult
Autor:
Edmund K. LeGrand
Publikováno v:
The American Journal of Surgery. 176:48S-54S
Advances in molecular biology have made possible the production of highly purified recombinant human proteins, and recombinant human growth factors have emerged as potential therapeutic wound healing agents. Becaplermin (recombinant human platelet-de
Autor:
Edmund K, LeGrand
Publikováno v:
Journal of the American Veterinary Medical Association. 242(1)
Autor:
Joe Alcock, Edmund K. LeGrand
Publikováno v:
The FASEB Journal. 26
Publikováno v:
Growth Factors. 8:307-314
A guinea pig partial thickness skin excision model was used to evaluate the effects of recombinant human PDGF-BB, PDGF-AA, EGF, and bFGF on granulation tissue (neodermis) formation. These growth factors tended to increase the thickness of the granula