Zobrazeno 1 - 10
of 650
pro vyhledávání: '"Edmund K, Waller"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 8, p 4391 (2024)
Antagonist peptides (ANTs) of vasoactive intestinal polypeptide receptors (VIP-Rs) are shown to enhance T cell activation and proliferation in vitro, as well as improving T cell-dependent anti-tumor response in acute myeloid leukemia (AML) murine mod
Externí odkaz:
https://doaj.org/article/5c7bd9e111fc4c82b182836c0e838451
Autor:
Sruthi Ravindranathan, Tenzin Passang, Jian-Ming Li, Shuhua Wang, Rohan Dhamsania, Michael Brandon Ware, Mohammad Y. Zaidi, Jingru Zhu, Maria Cardenas, Yuan Liu, Sanjeev Gumber, Brian Robinson, Anish Sen-Majumdar, Hanwen Zhang, Shanmuganathan Chandrakasan, Haydn Kissick, Alan B. Frey, Susan N. Thomas, Bassel F. El-Rayes, Gregory B. Lesinski, Edmund K. Waller
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Poor antitumor response of pancreatic cancer to immunotherapies is a major barrier to effective disease management. Herein we show that pancreatic cancers overexpress vasoactive intestinal peptide, and pharmacological inhibition of its signaling sign
Externí odkaz:
https://doaj.org/article/954e43b7b1f84c9eb8712e29586d1565
Autor:
Rae Hunter, Kathleen J. Imbach, Chengjing Zhou, Jodi Dougan, Jamie A. G. Hamilton, Kevin Z. Chen, Priscilla Do, Ashley Townsel, Greg Gibson, Erik C. Dreaden, Edmund K. Waller, Karmella A. Haynes, Curtis J. Henry, Christopher C. Porter
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Immunotherapies have revolutionized the treatment of B-cell acute lymphoblastic leukemia (B-ALL), but the duration of responses is still sub-optimal. We sought to identify mechanisms of immune suppression in B-ALL and strategies to overcome
Externí odkaz:
https://doaj.org/article/ef01154c5f714e0194d19821d23e87c0
Autor:
Hanwen Zhang, Tenzin Passang, Sruthi Ravindranathan, Ramireddy Bommireddy, Mohammad Raheel Jajja, Lily Yang, Periasamy Selvaraj, Chrystal M. Paulos, Edmund K. Waller
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
In the past decades, advances in the use of adoptive cellular therapy to treat cancer have led to unprecedented responses in patients with relapsed/refractory or late-stage malignancies. However, cellular exhaustion and senescence limit the efficacy
Externí odkaz:
https://doaj.org/article/2761c9d9689e4781abddac2165544691
Autor:
Jojo Y. Liu, Hanwen Zhang, Sruthi Ravindranathan, Taofeek K. Owonikoko, Bassel F. El‐Rayes, Yuan Liu, Edmund K. Waller
Publikováno v:
ImmunoMedicine, Vol 2, Iss 2, Pp n/a-n/a (2022)
Abstract Immune checkpoint molecules are critical targets of cancer therapies due to their ability to modulate immune responses to cancer. Vasoactive intestinal peptide (VIP) has been proposed as an immune checkpoint molecule, but its predictive and
Externí odkaz:
https://doaj.org/article/8c55b0443e8b4619a21e3b0c058b383d
Publikováno v:
Cancers, Vol 15, Iss 13, p 3284 (2023)
VIP (vasoactive intestinal peptide) is a 28-amino acid peptide hormone expressed by cancer and the healthy nervous system, digestive tract, cardiovascular, and immune cell tissues. Many cancers express VIP and its surface receptors VPAC1 and VPAC2, b
Externí odkaz:
https://doaj.org/article/76d598812fe943a2a190f62120e9d4b9
Autor:
Alan Sugar, MD, Munira Hussain, MS, Winston Chamberlain, MD, PhD, Reza Dana, MD, David Patrick Kelly, MD, Christopher Ta, MD, John Irvine, MD, Melissa Daluvoy, MD, Victor Perez, MD, Joshua Olson, MD, Vishal Jhanji, MD, Terence A. Walts, MBA, Robert Doyle Stulting, MD, PhD, Edmund K. Waller, MD, PhD, Neera Jagirdar, MD, MPH, Shahzad Mian, MD, Roni Shtein, MD, H. Kaz Soong, MD, Munira Hussain, Afshan Nanji, MD, MPH, John Clements, MD, Jennifer Maykovski, Paula Cisternas Labadzinzki, Jia Jin, MD, Joseph Ciolino, MD, John Caccaviello, D. Patrick Kelly, MD, Roya Habibi, OD, Charles Yu, MD, Charles Lin, MD, Kristin Hirabayashi, MD, Gabriel Valerio, MD, Supriya Kawale, Mariana Nunez, Olivia Lee, MD, Matthew Chu, Elmer Balajonda, Terry Hawks, Amanda Maltry, MD, Joshua Hou, MD, Wendy Elasky, Rose Carla Aubourg, R. Doyle Stulting, MD, PhD, Edmund Waller, MD, PhD, Neera Jagirdar, MD, Terence Walts
Publikováno v:
Ophthalmology Science, Vol 2, Iss 3, Pp 100176- (2022)
Purpose: The purpose of the study was to evaluate, as a pilot trial, safety and tolerability of CAM-101 10% and 30% topical ophthalmic fibrinogen-depleted human platelet lysate (FD hPL) solution in patients with dry eye disease (DED) secondary to gra
Externí odkaz:
https://doaj.org/article/11da6f8f0e9a445cb5f5eaa1c938aad7
Autor:
Elizabeth Stenger, Cynthia R. Giver, Amelia Langston, Daniel Kota, Pankoj Kumar Das, Raghavan Chinnadurai, Jacques Galipeau, Edmund K. Waller, Muna Qayed
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Despite the curative potential of hematopoietic cell transplantation (HCT) for hematologic malignancies, graft-versus-host disease (GVHD) remains a substantial cause of morbidity and mortality, particularly if treatment is refractory. Treatment with
Externí odkaz:
https://doaj.org/article/5a3104e1dc0b44048981f61e6756013a
Autor:
Ulrich Jaeger, Nina Worel, Joseph P. McGuirk, Peter A. Riedell, Isabelle Fleury, Yan Du, Xia Han, David Pearson, Santiago Redondo, Edmund K. Waller
Publikováno v:
Blood Advances. 7:2283-2286
Tisagenlecleucel demonstrated high response rates and a manageable safety profile in adults with relapsed/refractory diffuse large B-cell lymphoma (r/r DLBCL) in the JULIET trial. However, lack of response and chimeric antigen receptor (CAR) T-cell e
Autor:
Aleksandr Lazaryan, Michelle Dolan, Mei-Jie Zhang, Hai-Lin Wang, Mohamed A. Kharfan-Dabaja, David I. Marks, Nelli Bejanyan, Edward Copelan, Navneet S. Majhail, Edmund K. Waller, Nelson Chao, Tim Prestidge, Taiga Nishihori, Partow Kebriaei, Yoshihiro Inamoto, Betty Hamilton, Shahrukh K. Hashmi, Rammurti T. Kamble, Ulrike Bacher, Gerhard C. Hildebrandt, Patrick J. Stiff, Joseph McGuirk, Ibrahim Aldoss, Amer M. Beitinjaneh, Lori Muffly, Ravi Vij, Richard F. Olsson, Michael Byrne, Kirk R. Schultz, Mahmoud Aljurf, Matthew Seftel, Mary Lynn Savoie, Bipin N. Savani, Leo F. Verdonck, Mitchell S. Cairo, Nasheed Hossain, Vijaya Raj Bhatt, Haydar A. Frangoul, Hisham Abdel-Azim, Monzr Al Malki, Reinhold Munker, David Rizzieri, Nandita Khera, Ryotaro Nakamura, Olle Ringdén, Marjolein van der Poel, Hemant S. Murthy, Hongtao Liu, Shahram Mori, Satiro De Oliveira, Javier Bolaños-Meade, Mahmoud Elsawy, Pere Barba, Sunita Nathan, Biju George, Attaphol Pawarode, Michael Grunwald, Vaibhav Agrawal, Youjin Wang, Amer Assal, Paul Castillo Caro, Yachiyo Kuwatsuka, Sachiko Seo, Celalettin Ustun, Ioannis Politikos, Hillard M. Lazarus, Wael Saber, Brenda M. Sandmaier, Marcos De Lima, Mark Litzow, Veronika Bachanova, Daniel Weisdorf
Publikováno v:
Haematologica, Vol 106, Iss 8 (2021)
Externí odkaz:
https://doaj.org/article/5f4f65fecf5144b8af57be068ff20e60