Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Edmund J. Elder"'
Autor:
William R. Schwan, Jill M. Kolesar, M. Shahjahan Kabir, Edmund J. Elder, Jeffrey B. Williams, Rachel Minerath, James M. Cook, Christopher M. Witzigmann, Aaron Monte, Tricia Flaherty
Publikováno v:
Antibiotics, Vol 4, Iss 4, Pp 617-626 (2015)
Because of the potential of a new anti-staphylococcal lead compound SK-03-92 as a topical antibiotic, a patch, or an orally active drug, we sought to determine its safety profile and oral bioavailability. SK-03-92 had a high IC50 (125 μg/mL) in vitr
Externí odkaz:
https://doaj.org/article/226c22b06b6c46e8be3d487cad17bc9f
Publikováno v:
Epilepsybehavior : EB. 127
Cannabidiol products remains largely unregulated in the US. Unlike the Rx formulation of CBD [EpidiolexSamples were diluted and analyzed by HPLC for CBD, THC, and CBN concentrations in order to assess product label accuracy. Products with90% of label
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f01bcc1eafa6bb9b17e82aef74dc15af
https://pubmed.ncbi.nlm.nih.gov/34998268
https://pubmed.ncbi.nlm.nih.gov/34998268
Autor:
Edmund J. Elder, Rachel Minerath, Christopher M. Witzigmann, James M. Cook, Jeffrey B. Williams, Aaron Monte, William R. Schwan, M. Shahjahan Kabir, Jill M. Kolesar, Tricia Flaherty
Publikováno v:
Antibiotics, Vol 4, Iss 4, Pp 617-626 (2015)
Antibiotics
Antibiotics
Because of the potential of a new anti-staphylococcal lead compound SK-03-92 as a topical antibiotic, a patch, or an orally active drug, we sought to determine its safety profile and oral bioavailability. SK-03-92 had a high IC50 (125 μg/mL) in vitr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40e3cab8b34105d256f050c30d6f2497
http://www.mdpi.com/2079-6382/4/4/617
http://www.mdpi.com/2079-6382/4/4/617
Autor:
Timothy E. Welty, Edmund J. Elder, Jerzy P. Szaflarski, Michael Privitera, Barry E. Gidal, John R. Pollard, Francisco J. Diaz, Regina D. Switzer, Michel J. Berg, Barbara A. Dworetzky, Wenlei Jiang, Xiaohui Jiang, Ron Krebill
Importance Switching between generic antiepileptic drugs is a highly debated issue that affects both clinical care and overall health care costs. Objective To evaluate the single-dose pharmacokinetic bioequivalence of 3 (1 branded and 2 generic drugs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4570098670f85fddea48748c78326370
https://europepmc.org/articles/PMC5710324/
https://europepmc.org/articles/PMC5710324/
Autor:
Benjamin D. Johnson, Lee C. Vermeulen, Karen J. Jones, Edmund J. Elder, Joshua E. Medow, Lucas T Schulz, Ashwanth Vijayan
Publikováno v:
Hospital Pharmacy. 45:779-784
Purpose Thiosulfate has been shown to reduce the risk of cyanide toxicity during nitroprusside administration. Admixtures containing both agents may provide a safe and effective alternative to more expensive agents used to reduce blood pressure in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b77bcff2d57541e8561bbbd47d00e297
https://doi.org/10.1310/hpj4510-779
https://doi.org/10.1310/hpj4510-779
Autor:
James E. Hitt, Shakil A. Saghir, Brian D. Scherzer, Dan A. Markham, Gary B. Kupperblatt, Jonathan C. Evans, Edmund J. Elder
Publikováno v:
Drug Development and Industrial Pharmacy. 33:755-765
Many new molecular entities targeted for pharmaceutical applications face serious development challenges because of poor water solubility. Although particle engineering technologies such as controlled precipitation have been shown to enhance aqueous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4ad89f3a0aba228b14bf91977d68f1a
https://doi.org/10.1080/03639040601031882
https://doi.org/10.1080/03639040601031882
Autor:
Xiaohui Jiang, Barry E. Gidal, Francisco J. Diaz, Wenlei Jiang, Barbara A. Dworetzky, Ron Krebill, John R. Pollard, Michel J. Berg, Edmund J. Elder, Jerzy P. Szaflarski, Michael Privitera, Timothy E. Welty
Publikováno v:
The Lancet. Neurology. 15(4)
Summary Background Patients and clinicians share concerns that generic drug substitution might lead to loss of efficacy or emergence of adverse events. In this trial, we assessed US Food and Drug Administration (FDA) bioequivalence standards by study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a45a43967427a556a22294c4f170d2b0
https://pubmed.ncbi.nlm.nih.gov/26875742
https://pubmed.ncbi.nlm.nih.gov/26875742
Autor:
Charles F. Broomall, Jonathan C. Evans, Christopher J. Tucker, James E. Hitt, True L. Rogers, Ian B. Gillespie, Edmund J. Elder, Gary B. Kupperblatt, Clifford S. Todd, Deb L. Wilson, Kevin L. Fransen, Joe N. Becker, Cindy A. Crowl
Publikováno v:
Pharmaceutical Research. 21:2048-2057
Poorly water-soluble compounds are being found with increasing frequency among pharmacologically active new chemical entities, which is a major concern to the pharmaceutical industry. Some particle engineering technologies have been shown to enhance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::785ca149c9a585f0898e383c8278ae39
https://doi.org/10.1023/b:pham.0000048196.61887.e5
https://doi.org/10.1023/b:pham.0000048196.61887.e5
Autor:
True L. Rogers, Blair K. Brettmann, Robert O. Williams, Keith P. Johnston, Edmund J. Elder, Michal E. Matteucci
Publikováno v:
Molecular pharmaceutics. 4(5)
Controlled precipitation produced aqueous nanoparticle suspensions of a poorly water soluble drug, itraconazole (ITZ), in an amorphous state, despite unusually high potencies (drug weight/total weight) of up to 94%. Adsorption of the amphiphilic stab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4ab51d2cea6dbf00aa1d7c7f6d86f14
https://pubmed.ncbi.nlm.nih.gov/17715989
https://pubmed.ncbi.nlm.nih.gov/17715989
Publikováno v:
Drug Metabolism Reviews. 2004 Supplement 1, Vol. 36, p1-345. 345p.