Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Edmund J Gosselin"'
Autor:
Kristen M Holland-Tummillo, Lauren E Shoudy, Donald Steiner, Sudeep Kumar, Sarah J Rosa, Prachi Namjoshi, Anju Singh, Timothy J Sellati, Edmund J Gosselin, Karsten RO Hazlett
Publikováno v:
Pathogens, Vol 9, Iss 5, p 375 (2020)
The targeting of immunogens/vaccines to specific immune cells is a promising approach for amplifying immune responses in the absence of exogenous adjuvants. However, the targeting approaches reported thus far require novel, labor-intensive reagents f
Externí odkaz:
https://doaj.org/article/484edf1479024073855adabfe8a88377
Autor:
Raju Sunagar, Sudeep Kumar, Prachi Namjoshi, Sarah J Rosa, Karsten R O Hazlett, Edmund J Gosselin
Publikováno v:
PLoS ONE, Vol 13, Iss 12, p e0207587 (2018)
Francisella tularensis (Ft) is a biothreat agent for which there is no FDA-approved human vaccine. Currently, there are substantial efforts underway to develop both vaccines and the tools to assess these vaccines. Tularemia laboratory research has hi
Externí odkaz:
https://doaj.org/article/e4fdf5fdb3f34f85b959a55d40ccc73f
Autor:
Ragavan Varadharajan Suresh, Zhuo Ma, Raju Sunagar, Vivek Bhatty, Sukalyani Banik, Sally V Catlett, Edmund J Gosselin, Meenakshi Malik, Chandra Shekhar Bakshi
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0124326 (2015)
Tularemia is caused by a gram-negative, intracellular bacterial pathogen, Francisella tularensis (Ft). The history weaponization of Ft in the past has elevated concerns that it could be used as a bioweapon or an agent of bioterrorism. Since the disco
Externí odkaz:
https://doaj.org/article/ad2e3e4dd0ef41e1b7eb102fa226ce43
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0129981 (2015)
Production of pro-inflammatory cytokines by innate immune cells at the early stages of bacterial infection is important for host protection against the pathogen. Many intracellular bacteria, including Francisella tularensis, the agent of tularemia, u
Externí odkaz:
https://doaj.org/article/fb3711ba6cc0403a9a598bd910c177f9
Autor:
Tiffany M Zarrella, Anju Singh, Constantine Bitsaktsis, Tabassum Rahman, Bikash Sahay, Paul J Feustel, Edmund J Gosselin, Timothy J Sellati, Karsten R O Hazlett
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e22335 (2011)
The gram-negative bacterium Francisella tularensis survives in arthropods, fresh water amoeba, and mammals with both intracellular and extracellular phases and could reasonably be expected to express distinct phenotypes in these environments. The pre
Externí odkaz:
https://doaj.org/article/d26e982887ab4c3e88ea0d1b47b2e207
Autor:
Prachi Namjoshi, Timothy J. Sellati, Sarah J. Rosa, Edmund J. Gosselin, Lauren E Shoudy, Donald Steiner, Sudeep Kumar, Kristen M Holland-Tummillo, Karsten R. O. Hazlett, Anju Singh
Publikováno v:
Pathogens
Volume 9
Issue 5
Pathogens, Vol 9, Iss 375, p 375 (2020)
Volume 9
Issue 5
Pathogens, Vol 9, Iss 375, p 375 (2020)
The targeting of immunogens/vaccines to specific immune cells is a promising approach for amplifying immune responses in the absence of exogenous adjuvants. However, the targeting approaches reported thus far require novel, labor-intensive reagents f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::862f94e54aa76246cdb9aacd08c90307
Publikováno v:
Vaccines, Vol 8, Iss 193, p 193 (2020)
Vaccines
Volume 8
Issue 2
Vaccines
Volume 8
Issue 2
Lack of safe and effective mucosal adjuvants has severely hampered the development of mucosal subunit vaccines. In this regard, we have previously shown that immunogenicity of vaccine antigens can be improved by targeting the antigens to the antigen-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0862e3e636409d42802047b5acf2eff6
https://www.mdpi.com/2076-393X/8/2/193
https://www.mdpi.com/2076-393X/8/2/193
Publikováno v:
Vaccine. 35:1080-1086
Numerous studies have demonstrated that administration of antigen (Ag)-pulsed dendritic cells (DCs) is an effective strategy for enhancing immunity to tumors and infectious disease organisms. However, the generation and/or isolation of DCs can requir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d9a5368f0131538a01b396743ddb77a
https://doi.org/10.1016/j.vaccine.2016.12.035
https://doi.org/10.1016/j.vaccine.2016.12.035
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Frontiers in Immunology
Frontiers in Immunology
Adjuvants have been used in vaccines for over a century, however, the search for safe and effective vaccine adjuvants continues. In recent decades toll-like-receptor (TLR) agonists have been investigated as potential vaccine adjuvants. In this regard
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8518aa3e06967484d1b1b860c7457b0b
https://doi.org/10.3389/fimmu.2019.01144
https://doi.org/10.3389/fimmu.2019.01144
Publikováno v:
Cell Immunol
Previous in vivo studies established that inactivated Francisella tularensis immune complexes (mAb-iFt) are a more protective vaccine against lethal tularemia than iFt alone. Subsequent in vitro studies revealed enhanced DC maturation marker expressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acfab9090c11fdd72336b9218d00de1d
https://pubmed.ncbi.nlm.nih.gov/31582169
https://pubmed.ncbi.nlm.nih.gov/31582169