Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Edmund J, Keliher"'
Autor:
Ryosuke Arakawa, Akihiro Takano, Sangram Nag, Zhisheng Jia, Nahid Amini, Kevin P. Maresca, Lei Zhang, Edmund J. Keliher, Christopher R. Butler, Justin R. Piro, Tarek A. Samad, Deborah Smith, Deane Nason, Steve O’Neil, Patrick Trapa, Kari R. Fonseca, John Litchfield, Timothy McCarthy, Richard E. Carson, Christer Halldin
Publikováno v:
EJNMMI Research, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Background Monoacylglycerol lipase (MAGL) is a key serine hydrolase which terminates endocannabinoid signaling and regulates arachidonic acid driven inflammatory responses within the central nervous system. To develop [11C]PF-06809247 into a
Externí odkaz:
https://doaj.org/article/0b2d2f0ac72047df80a3f5d00a8935c1
Autor:
Matthias W. G. Zeller, Cuihua Wang, Edmund J. Keliher, Gregory R. Wojtkiewicz, Aaron Aguirre, Kevin Maresca, Chunyan Su, Leonard Buckbinder, Jing Wang, Matthias Nahrendorf, John W. Chen
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 6, p 5704 (2023)
Myeloperoxidase (MPO) is a highly oxidative, pro-inflammatory enzyme involved in post-myocardial infarction (MI) injury and is a potential therapeutic target. While multiple MPO inhibitors have been developed, the lack of an imaging reporter to selec
Externí odkaz:
https://doaj.org/article/bd92d331b76741f0b77afa75f1a28b53
Autor:
Jessica R. Ingram, Michael Dougan, Mohammad Rashidian, Marko Knoll, Edmund J. Keliher, Sarah Garrett, Scott Garforth, Olga S. Blomberg, Camilo Espinosa, Atul Bhan, Steven C. Almo, Ralph Weissleder, Harvey Lodish, Stephanie K. Dougan, Hidde L. Ploegh
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Current approaches to visualise brown adipose tissue (BAT) rely primarily on markers that reflect its metabolic activity. Here, the authors show that PD-L1 is expressed on brown adipocytes, does not change upon BAT activation, and that BAT volume in
Externí odkaz:
https://doaj.org/article/2cbbcd069f884ad59674351eae9c1223
Autor:
Edmund J. Keliher, Yu-Xiang Ye, Gregory R. Wojtkiewicz, Aaron D. Aguirre, Benoit Tricot, Max L. Senders, Hannah Groenen, Francois Fay, Carlos Perez-Medina, Claudia Calcagno, Giuseppe Carlucci, Thomas Reiner, Yuan Sun, Gabriel Courties, Yoshiko Iwamoto, Hye-Yeong Kim, Cuihua Wang, John W. Chen, Filip K. Swirski, Hsiao-Ying Wey, Jacob Hooker, Zahi A. Fayad, Willem J. M. Mulder, Ralph Weissleder, Matthias Nahrendorf
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
In vivo imaging of inflammation is crucial for detection and monitoring of many pathologies and noninvasive macrophage quantification has been suggested as a possible approach. Here Keliher et al. describe novel polyglucose nanoparticle tracers that
Externí odkaz:
https://doaj.org/article/a325edd59ddf4dab8474aa0b334a7eea
Autor:
Rachel J Roth Flach, Chunyan Su, Eliza Bollinger, Christian Cortes, Andrew W Robertson, Alan C Opsahl, Timothy M Coskran, Kevin P Maresca, Edmund J Keliher, Phillip D Yates, Albert M Kim, Amit S Kalgutkar, Leonard Buckbinder
Publikováno v:
PLoS ONE, Vol 14, Iss 3, p e0214150 (2019)
Myeloperoxidase (MPO) is a highly abundant protein within the neutrophil that is associated with lipoprotein oxidation, and increased plasma MPO levels are correlated with poor prognosis after myocardial infarct. Thus, MPO inhibitors have been develo
Externí odkaz:
https://doaj.org/article/1d4d82c1feff4fad91bb96d03ddfbae9
Autor:
Mohammad Rashidian, Edmund J. Keliher, Michael Dougan, Patrick K. Juras, Marco Cavallari, Gregory R. Wojtkiewicz, Johanne T. Jacobsen, Jerre G. Edens, Jeroen M. J. Tas, Gabriel Victora, Ralph Weissleder, Hidde Ploegh
Publikováno v:
ACS Central Science, Vol 1, Iss 3, Pp 142-147 (2015)
Externí odkaz:
https://doaj.org/article/fa0d850c72014ae384393143eb3b7ce6
Autor:
Eve H. Pickering, Keith Kobylarz, Jianqing Chen, Jonathan Golas, Ohad Ilovich, Lindsay King, Sripad Ram, Kevin P. Maresca, Timothy J. McCarthy, Laigao Chen, James S. Hardwick, Amira Hussein, Jatin Narula, Edward Rosfjord, Anand Giddabasappa, Edmund J. Keliher, Ian D. Wilson, Adam Root, David Schaer, Divya Mathur, Paul A. Rejto, Kevin Staton
Publikováno v:
Molecular Imaging and Biology
Purpose A sensitive and specific imaging biomarker to monitor immune activation and quantify pharmacodynamic responses would be useful for development of immunomodulating anti-cancer agents. PF-07062119 is a T cell engaging bispecific antibody that b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef2d5a9aa5061121cdb634e6b8a7982c
http://europepmc.org/articles/PMC8578158
http://europepmc.org/articles/PMC8578158
Autor:
Edmund J. Keliher, Thomas Reiner, Sarah Earley, Jenna Klubnick, Carlos Tassa, Andrew J. Lee, Sridhar Ramaswamy, Nabeel Bardeesy, Douglas Hanahan, Ronald A. DePinho, Cesar M. Castro, Ralph Weissleder
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 15, Iss 7, Pp 684-693 (2013)
When resectable, invasive pancreatic ductal adenocarcinoma (PDAC) is most commonly treated with surgery and radiochemotherapy. Given the intricate local anatomy and locoregional mode of dissemination, achieving clean surgical margins can be a signifi
Externí odkaz:
https://doaj.org/article/937c1a9d4cf24cadbd48cb4cc2afc3f2
Autor:
Thomas Reiner, Jessica Lacy, Edmund J. Keliher, Katherine S. Yang, Adeeti Ullal, Rainer H. Kohler, Claudio Vinegoni, Ralph Weissleder
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 14, Iss 3, Pp 169-177 (2012)
A number of small-molecule poly (ADP-ribose) polymerase (PARP) inhibitors are currently undergoing advanced clinical trials. Determining the distribution and target inhibitory activity of these drugs in individual subjects, however, has proven proble
Externí odkaz:
https://doaj.org/article/2417ddf1ea704c5daa21b5a6321bd5a6
Autor:
Akihiro Takano, Nahid Amini, Edmund J. Keliher, Christer Halldin, Lei Zhang, Richard E. Carson, Patrick Trapa, Sangram Nag, Ryosuke Arakawa, Deane M. Nason, Kevin P. Maresca, Zhisheng Jia, John Litchfield, Tarek A. Samad, Christopher Ryan Butler, Justin R. Piro, Timothy J. McCarthy, Deborah L. Smith, Steve O’Neil, Kari R. Fonseca
Background Monoacylglycerol lipase (MAGL) is a key serine hydrolase which terminates endocannabinoid signaling and regulates arachidonic acid driven inflammatory responses within the central nervous system. To develop [11C]PF-06809247 into a clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17b463c48140050426b0c96d37c2ff81
https://doi.org/10.21203/rs.3.rs-510615/v2
https://doi.org/10.21203/rs.3.rs-510615/v2
