Výsledky vyhledávání - "Edmund J, Gosselin"

Akademický článek

Autotransporter-Mediated Display of Complement Receptor Ligands by Gram-Negative Bacteria Increases Antibody Responses and Limits Disease Severity

Autor: Kristen M Holland-Tummillo, Lauren E Shoudy, Donald Steiner, Sudeep Kumar, Sarah J Rosa, Prachi Namjoshi, Anju Singh, Timothy J Sellati, Edmund J Gosselin, Karsten RO Hazlett

Publikováno v: Pathogens, Vol 9, Iss 5, p 375 (2020)

The targeting of immunogens/vaccines to specific immune cells is a promising approach for amplifying immune responses in the absence of exogenous adjuvants. However, the targeting approaches reported thus far require novel, labor-intensive reagents f

Externí odkaz: https://doaj.org/article/484edf1479024073855adabfe8a88377

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Akademický článek

Preclinical Efficacy of a Trivalent Human FcγRI-Targeted Adjuvant-Free Subunit Mucosal Vaccine against Pulmonary Pneumococcal Infection

Autor: Sudeep Kumar, Raju Sunagar, Edmund J. Gosselin

Publikováno v: Vaccines, Vol 8, Iss 2, p 193 (2020)

Lack of safe and effective mucosal adjuvants has severely hampered the development of mucosal subunit vaccines. In this regard, we have previously shown that immunogenicity of vaccine antigens can be improved by targeting the antigens to the antigen-

Externí odkaz: https://doaj.org/article/adb0e95860d746b99c0c95b7ac36a018

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Akademický článek

Differential In Vitro Cultivation of Francisella tularensis Influences Live Vaccine Protective Efficacy by Altering the Immune Response

Autor: Raju Sunagar, Sudeep Kumar, Sarah J. Rosa, Karsten R. O. Hazlett, Edmund J. Gosselin

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

Francisella tularensis (Ft) is a biothreat agent for which there is no FDA-approved human vaccine. Currently, there are substantial efforts underway to develop both vaccines and improved tools to assess these vaccines. Ft expresses distinct sets of a

Externí odkaz: https://doaj.org/article/f7b23b2a99fd4d44bfb40e479694f39b

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Akademický článek

Evaluation of an outbred mouse model for Francisella tularensis vaccine development and testing.

Autor: Raju Sunagar, Sudeep Kumar, Prachi Namjoshi, Sarah J Rosa, Karsten R O Hazlett, Edmund J Gosselin

Publikováno v: PLoS ONE, Vol 13, Iss 12, p e0207587 (2018)

Francisella tularensis (Ft) is a biothreat agent for which there is no FDA-approved human vaccine. Currently, there are substantial efforts underway to develop both vaccines and the tools to assess these vaccines. Tularemia laboratory research has hi

Externí odkaz: https://doaj.org/article/e4fdf5fdb3f34f85b959a55d40ccc73f

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Akademický článek

Differential Growth of Francisella tularensis, Which Alters Expression of Virulence Factors, Dominant Antigens, and Surface-Carbohydrate Synthases, Governs the Apparent Virulence of Ft SchuS4 to Immunized Animals

Autor: Kristen M. Holland, Sarah J. Rosa, Kolbrun Kristjansdottir, Donald Wolfgeher, Brian J. Franz, Tiffany M. Zarrella, Sudeep Kumar, Raju Sunagar, Anju Singh, Chandra S. Bakshi, Prachi Namjoshi, Eileen M. Barry, Timothy J. Sellati, Stephen J. Kron, Edmund J. Gosselin, Douglas S. Reed, Karsten R. O. Hazlett

Publikováno v: Frontiers in Microbiology, Vol 8 (2017)

The gram-negative bacterium Francisella tularensis (Ft) is both a potential biological weapon and a naturally occurring microbe that survives in arthropods, fresh water amoeba, and mammals with distinct phenotypes in various environments. Previously,

Externí odkaz: https://doaj.org/article/9fad3173896d4d9495261add6d16382a

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Akademický článek

Downmodulation of Vaccine-Induced Immunity and Protection against the Intracellular Bacterium Francisella tularensis by the Inhibitory Receptor FcγRIIB

Autor: Brian J. Franz, Ying Li, Constantine Bitsaktsis, Bibiana V. Iglesias, Giang Pham, Raju Sunagar, Sudeep Kumar, Edmund J. Gosselin

Publikováno v: Journal of Immunology Research, Vol 2015 (2015)

Fc gamma receptor IIB (FcγRIIB) is the only Fc gamma receptor (FcγR) which negatively regulates the immune response, when engaged by antigen- (Ag-) antibody (Ab) complexes. Thus, the generation of Ag-specific IgG in response to infection or immuniz

Externí odkaz: https://doaj.org/article/299949b81aee4386ba48c654c6fa9881

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Akademický článek

Preclinical testing of a vaccine candidate against tularemia.

Autor: Ragavan Varadharajan Suresh, Zhuo Ma, Raju Sunagar, Vivek Bhatty, Sukalyani Banik, Sally V Catlett, Edmund J Gosselin, Meenakshi Malik, Chandra Shekhar Bakshi

Publikováno v: PLoS ONE, Vol 10, Iss 4, p e0124326 (2015)

Tularemia is caused by a gram-negative, intracellular bacterial pathogen, Francisella tularensis (Ft). The history weaponization of Ft in the past has elevated concerns that it could be used as a bioweapon or an agent of bioterrorism. Since the disco

Externí odkaz: https://doaj.org/article/ad2e3e4dd0ef41e1b7eb102fa226ce43

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Akademický článek

Targeting of a Fixed Bacterial Immunogen to Fc Receptors Reverses the Anti-Inflammatory Properties of the Gram-Negative Bacterium, Francisella tularensis, during the Early Stages of Infection.

Autor: Zulfia Babadjanova, Kari Wiedinger, Edmund J Gosselin, Constantine Bitsaktsis

Publikováno v: PLoS ONE, Vol 10, Iss 6, p e0129981 (2015)

Production of pro-inflammatory cytokines by innate immune cells at the early stages of bacterial infection is important for host protection against the pathogen. Many intracellular bacteria, including Francisella tularensis, the agent of tularemia, u

Externí odkaz: https://doaj.org/article/fb3711ba6cc0403a9a598bd910c177f9

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