Drug-Like Properties in Macrocycles above MW 1000: Backbone Rigidity versus Side-Chain Lipophilicity.

Autor: Furukawa A; Daiichi Sankyo Co., Ltd., 1-2-58, Hiromachi, Shinagawa-ku, Tokyo, 140-8710, Japan., Schwochert J; Unnatural Products, Inc., 250 Natural Bridges Drive, Santa Cruz, CA, 95060, USA., Pye CR; Unnatural Products, Inc., 250 Natural Bridges Drive, Santa Cruz, CA, 95060, USA., Asano D; Daiichi Sankyo Co., Ltd., 1-2-58, Hiromachi, Shinagawa-ku, Tokyo, 140-8710, Japan., Edmondson QD; Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California, 94158, USA., Turmon AC; Unnatural Products, Inc., 250 Natural Bridges Drive, Santa Cruz, CA, 95060, USA., Klein VG; Department of Chemistry & Biochemistry, University of California Santa Cruz, Santa Cruz, CA, 96064, USA., Ono S; Discovery Technology Laboratories, Mitsubishi Tanabe Pharma Corporation, Yokohama, 227-0033, Japan., Okada O; Discovery Technology Laboratories, Mitsubishi Tanabe Pharma Corporation, Yokohama, 227-0033, Japan., Lokey RS; Department of Chemistry & Biochemistry, University of California Santa Cruz, Santa Cruz, CA, 96064, USA.

Publikováno v: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2020 Nov 23; Vol. 59 (48), pp. 21571-21577. Date of Electronic Publication: 2020 Sep 17.