Zobrazeno 1 - 10
of 600
pro vyhledávání: '"Edmond Y"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Cyclodextrins (CDs) have been previously shown to display modest equilibrium binding affinities (K a ~ 100–200 M-1) for the synthetic opioid analgesic fentanyl. In this work, we describe the synthesis of new CDs possessing extended thioalk
Externí odkaz:
https://doaj.org/article/c0237041f69348bfa38622d6f61592ba
Publikováno v:
Frontiers in Energy Research, Vol 11 (2023)
Externí odkaz:
https://doaj.org/article/4f8d8452defe49f1b537f50bce04e4c0
Autor:
Fangqiang Zhu, Feliza A. Bourguet, William F. D. Bennett, Edmond Y. Lau, Kathryn T. Arrildt, Brent W. Segelke, Adam T. Zemla, Thomas A. Desautels, Daniel M. Faissol
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Alchemical free energy perturbation (FEP) is a rigorous and powerful technique to calculate the free energy difference between distinct chemical systems. Here we report our implementation of automated large-scale FEP calculations, using the
Externí odkaz:
https://doaj.org/article/3e982ed42e934f87b6cebdbe7454397c
Autor:
Edmond Y Lau, Heather A Enright, Victoria Lao, Michael A Malfatti, Brian P Mayer, Audrey M Williams, Carlos A Valdez
Publikováno v:
PLoS ONE, Vol 18, Iss 3, p e0283181 (2023)
The ability of the cyclodextrin-oxime construct 6-OxP-CD to bind and degrade the nerve agents Cyclosarin (GF), Soman (GD) and S-[2-[Di(propan-2-yl)amino]ethyl] O-ethyl methylphosphonothioate (VX) has been studied using 31P-nuclear magnetic resonance
Externí odkaz:
https://doaj.org/article/a66dd0613968444c9e5f77db86912e80
Autor:
Edmond Y. Lau, Oscar A. Negrete, W. F. Drew Bennett, Brian J. Bennion, Monica Borucki, Feliza Bourguet, Aidan Epstein, Magdalena Franco, Brooke Harmon, Stewart He, Derek Jones, Hyojin Kim, Daniel Kirshner, Victoria Lao, Jacky Lo, Kevin McLoughlin, Richard Mosesso, Deepa K. Murugesh, Edwin A. Saada, Brent Segelke, Maxwell A. Stefan, Garrett A. Stevenson, Marisa W. Torres, Dina R. Weilhammer, Sergio Wong, Yue Yang, Adam Zemla, Xiaohua Zhang, Fangqiang Zhu, Jonathan E. Allen, Felice C. Lightstone
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
A rapid response is necessary to contain emergent biological outbreaks before they can become pandemics. The novel coronavirus (SARS-CoV-2) that causes COVID-19 was first reported in December of 2019 in Wuhan, China and reached most corners of the gl
Externí odkaz:
https://doaj.org/article/d413250ed30f441981cd5475fb7487b8
Publikováno v:
Antibodies, Vol 11, Iss 3, p 51 (2022)
The accurate and efficient calculation of protein-protein binding affinities is an essential component in antibody and antigen design and optimization, and in computer modeling of antibody affinity maturation. Such calculations remain challenging des
Externí odkaz:
https://doaj.org/article/fc7fe7d53b6b4756b75a28e8208902e6
Publikováno v:
Journal of Flood Risk Management, Vol 14, Iss 1, Pp n/a-n/a (2021)
Abstract The changing climate and the rapid urbanisation may alter flood severity and influence the decision‐making process for flood management. In this study, a Multi‐Criteria Decision Analysis (MCDA) framework for optimal decision‐making in
Externí odkaz:
https://doaj.org/article/897a2139b5d848c596e1039d4fb1a506
Autor:
Steven F. Buchsbaum, Melinda L. Jue, April M. Sawvel, Chiatai Chen, Eric R. Meshot, Sei Jin Park, Marissa Wood, Kuang Jen Wu, Camille L. Bilodeau, Fikret Aydin, Tuan Anh Pham, Edmond Y. Lau, Francesco Fornasiero
Publikováno v:
Advanced Science, Vol 8, Iss 3, Pp n/a-n/a (2021)
Abstract Simulations and experiments have revealed enormous transport rates through carbon nanotube (CNT) channels when a pressure gradient drives fluid flow, but comparatively little attention has been given to concentration‐driven transport despi
Externí odkaz:
https://doaj.org/article/a95d59c1241a44c1bd49e361c0df5a13
Publikováno v:
Advances in Meteorology, Vol 2017 (2017)
The impact of changing climate on the frequency of daily rainfall extremes in Jakarta, Indonesia, is analysed and quantified. The study used three different models to assess the changes in rainfall characteristics. The first method involves the use o
Externí odkaz:
https://doaj.org/article/42621db31419491caa7b082d1e81c1cb
Autor:
Tahira Anwar, Xiaonan Liu, Taina Suntio, Annika Marjamäki, Joanna Biazik, Edmond Y. W. Chan, Markku Varjosalo, Eeva-Liisa Eskelinen
Publikováno v:
Cells, Vol 8, Iss 5, p 475 (2019)
Autophagy transports cytoplasmic material and organelles to lysosomes for degradation and recycling. Beclin 1 forms a complex with several other autophagy proteins and functions in the initiation phase of autophagy, but the exact role of Beclin 1 sub
Externí odkaz:
https://doaj.org/article/59c28bfab19b4d038a1278bff0e37618