Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Edmond Wong"'
Autor:
Alice Fletcher, Dean Clift, Emma de Vries, Sergio Martinez Cuesta, Timothy Malcolm, Francesco Meghini, Raghothama Chaerkady, Junmin Wang, Abby Chiang, Shao Huan Samuel Weng, Jonathan Tart, Edmond Wong, Gerard Donohoe, Philip Rawlins, Euan Gordon, Jonathan D. Taylor, Leo James, James Hunt
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Human antigen R (HuR) is a ubiquitously expressed RNA-binding protein, which functions as an RNA regulator. Overexpression of HuR correlates with high grade tumours and poor patient prognosis, implicating it as an attractive therapeutic targ
Externí odkaz:
https://doaj.org/article/0a4a30a2a8bb41ef8d8998148778ebbb
Autor:
Bianca A. Trombetta, Savannah E. Kandigian, Robert R. Kitchen, Korneel Grauwet, Pia Kivisäkk Webb, Glenn A. Miller, Charles G. Jennings, Sejal Jain, Samara Miller, Yikai Kuo, Thadryan Sweeney, Tal Gilboa, Maia Norman, Daimon P. Simmons, Christopher E. Ramirez, Melissa Bedard, Catherine Fink, Jina Ko, Esmarline J. De León Peralta, Gerald Watts, Emma Gomez-Rivas, Vannessa Davis, Rocky M. Barilla, Jianing Wang, Pierre Cunin, Samuel Bates, Chevaun Morrison-Smith, Benjamin Nicholson, Edmond Wong, Leena El-Mufti, Michael Kann, Anna Bolling, Brooke Fortin, Hayden Ventresca, Wen Zhou, Santiago Pardo, Megan Kwock, Aditi Hazra, Leo Cheng, Q. Rushdy Ahmad, James A. Toombs, Rebecca Larson, Haley Pleskow, Nell Meosky Luo, Christina Samaha, Unnati M. Pandya, Pushpamali De Silva, Sally Zhou, Zakary Ganhadeiro, Sara Yohannes, Rakeisha Gay, Jacqueline Slavik, Shibani S. Mukerji, Petr Jarolim, David R. Walt, Becky C. Carlyle, Lauren L. Ritterhouse, Sara Suliman
Publikováno v:
BMC Infectious Diseases, Vol 21, Iss 1, Pp 1-14 (2021)
Abstract Background COVID-19 has resulted in significant morbidity and mortality worldwide. Lateral flow assays can detect anti-Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) antibodies to monitor transmission. However, standardized eva
Externí odkaz:
https://doaj.org/article/019aff5557364e74bdca28b0b1adff41
Autor:
Edmond Wong, Vishnu Jeganathan, Samuel Wreghitt, Gavin Davis, Hari Wimaleswaran, Mark E Howard
Publikováno v:
Respirology Case Reports, Vol 8, Iss 8, Pp n/a-n/a (2020)
Abstract Ventriculo‐pleural (VPL) shunt insertion is performed in hydrocephalic patients when alternative sites of cerebrospinal fluid (CSF) diversion are contraindicated. These include patients with peritoneal complications from ventriculo‐perit
Externí odkaz:
https://doaj.org/article/d1433193bc404013a1389fcdeb8f6f70
Autor:
Bianca A. Trombetta, Savannah E. Kandigian, Robert R. Kitchen, Korneel Grauwet, Pia Kivisäkk Webb, Glenn A. Miller, Charles G. Jennings, Sejal Jain, Samara Miller, Yikai Kuo, Thadryan Sweeney, Tal Gilboa, Maia Norman, Daimon P. Simmons, Christopher E. Ramirez, Melissa Bedard, Catherine Fink, Jina Ko, Esmarline J. De León Peralta, Gerald Watts, Emma Gomez-Rivas, Vannessa Davis, Rocky M. Barilla, Jianing Wang, Pierre Cunin, Samuel Bates, Chevaun Morrison-Smith, Benjamin Nicholson, Edmond Wong, Leena El-Mufti, Michael Kann, Anna Bolling, Brooke Fortin, Hayden Ventresca, Wen Zhou, Santiago Pardo, Megan Kwock, Aditi Hazra, Leo Cheng, Q. Rushdy Ahmad, James A. Toombs, Rebecca Larson, Haley Pleskow, Nell Meosky Luo, Christina Samaha, Unnati M. Pandya, Pushpamali De Silva, Sally Zhou, Zakary Ganhadeiro, Sara Yohannes, Rakiesha Gay, Jacqueline Slavik, Shibani S. Mukerji, Petr Jarolim, David R. Walt, Becky C. Carlyle, Lauren L. Ritterhouse, Sara Suliman
Publikováno v:
BMC Infectious Diseases, Vol 21, Iss 1, Pp 1-2 (2021)
Externí odkaz:
https://doaj.org/article/9bc96019ccbf40a28e5cc85682a0a561
Autor:
Edmond Wong, Gustav Vaaje-Kolstad, Avishek Ghosh, Ramon Hurtado-Guerrero, Peter V Konarev, Adel F M Ibrahim, Dmitri I Svergun, Vincent G H Eijsink, Nabendu S Chatterjee, Daan M F van Aalten
Publikováno v:
PLoS Pathogens, Vol 8, Iss 1, p e1002373 (2012)
Vibrio cholerae is a bacterial pathogen that colonizes the chitinous exoskeleton of zooplankton as well as the human gastrointestinal tract. Colonization of these different niches involves an N-acetylglucosamine binding protein (GbpA) that has been r
Externí odkaz:
https://doaj.org/article/770d539436de4006b01fbb1db03c7b29
Autor:
Jun Tian, Jonathan H. Chen, Sherry X. Chao, Karin Pelka, Marios Giannakis, Julian Hess, Kelly Burke, Vjola Jorgji, Princy Sindurakar, Jonathan Braverman, Arnav Mehta, Tomonori Oka, Mei Huang, David Lieb, Maxwell Spurrell, Jill N. Allen, Thomas A. Abrams, Jeffrey W. Clark, Andrea C. Enzinger, Peter C. Enzinger, Samuel J. Klempner, Nadine J. McCleary, Jeffrey A. Meyerhardt, David P. Ryan, Matthew B. Yurgelun, Katie Kanter, Emily E. Van Seventer, Islam Baiev, Gary Chi, Joy Jarnagin, William B. Bradford, Edmond Wong, Alexa G. Michel, Isobel J. Fetter, Giulia Siravegna, Angelo J. Gemma, Arlene Sharpe, Shadmehr Demehri, Rebecca Leary, Catarina D. Campbell, Omer Yilmaz, Gad A. Getz, Aparna R. Parikh, Nir Hacohen, Ryan B. Corcoran
Publikováno v:
Nature Medicine. 29:458-466
While BRAF inhibitor combinations with EGFR and/or MEK inhibitors have improved clinical efficacy in BRAFV600E colorectal cancer (CRC), response rates remain low and lack durability. Preclinical data suggest that BRAF/MAPK pathway inhibition may augm
Autor:
Ryan B. Corcoran, Catriona B. Hong, Heather A. Shahzade, Edmond Wong, David T. Myers, Sarah Phat, Ferran Fece de la Cruz, Meagan B. Ryan
Supplementary Figure S9. Combined SHP2 and KRASG12C inhibition improves efficacy in vivo.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36e0ce62dc6842a3a9f85242ad681822
https://doi.org/10.1158/1078-0432.22478093
https://doi.org/10.1158/1078-0432.22478093
Autor:
Ryan B. Corcoran, Catriona B. Hong, Heather A. Shahzade, Edmond Wong, David T. Myers, Sarah Phat, Ferran Fece de la Cruz, Meagan B. Ryan
Purpose:Although KRAS represents the most commonly mutated oncogene, it has long been considered an “undruggable” target. Novel covalent inhibitors selective for the KRASG12C mutation offer the unprecedented opportunity to target KRAS directly. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bd99c24a4188efa3cd8bb5f973c75ef
https://doi.org/10.1158/1078-0432.c.6529850
https://doi.org/10.1158/1078-0432.c.6529850
Autor:
Ryan B. Corcoran, Catriona B. Hong, Heather A. Shahzade, Edmond Wong, David T. Myers, Sarah Phat, Ferran Fece de la Cruz, Meagan B. Ryan
Supplementary Figure S7. SHP2 inhibition enhances the efficacy of KRASG12C inhibition.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39395c08f5ef84dd29915965529ee5b6
https://doi.org/10.1158/1078-0432.22478099
https://doi.org/10.1158/1078-0432.22478099
Autor:
Ryan B. Corcoran, Catriona B. Hong, Heather A. Shahzade, Edmond Wong, David T. Myers, Sarah Phat, Ferran Fece de la Cruz, Meagan B. Ryan
Supplementary Figure S8. KRASG12C and SHP2 inhibition does not inhibit the growth of signaling of a non-KRASG12C mutant cell line.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dea6172ea0f7bb8bb3ec9751e69a708
https://doi.org/10.1158/1078-0432.22478096.v1
https://doi.org/10.1158/1078-0432.22478096.v1