Zobrazeno 1 - 10
of 623
pro vyhledávání: '"Edmond I. Eger"'
Autor:
David J Speca, Daisuke Chihara, Amir M Ashique, M Scott Bowers, Jonathan T Pierce-Shimomura, Jungsoo Lee, Nusrat Rabbee, Terence P Speed, Rodrigo J Gularte, James Chitwood, Juan F Medrano, Mark Liao, James M Sonner, Edmond I Eger, Andrew S Peterson, Steven L McIntire
Publikováno v:
PLoS Genetics, Vol 6, Iss 8 (2010)
The mechanisms by which ethanol and inhaled anesthetics influence the nervous system are poorly understood. Here we describe the positional cloning and characterization of a new mouse mutation isolated in an N-ethyl-N-nitrosourea (ENU) forward mutage
Externí odkaz:
https://doaj.org/article/5dc2d1d7fb384d018c6302692b45a509
Autor:
Vinuta Rau, Uwe Rudolph, Robert A. Pearce, Irene Oh, F. C. Rodgers, Edmond I. Eger, Rachel Jurd, C. Lor, Kurt T. Laha, Ewa D. Zarnowska
Publikováno v:
Neuropharmacology. 93:171-178
Enhancement of tonic inhibition mediated by extrasynaptic α5-subunit containing GABAA receptors (GABAARs) has been proposed as the mechanism by which a variety of anesthetics, including the general anesthetic etomidate, impair learning and memory. S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94e3c261e203893e69dc2eeeadb36f22
https://doi.org/10.1016/j.neuropharm.2015.01.011
https://doi.org/10.1016/j.neuropharm.2015.01.011
Autor:
Edmond I Eger nd
Publikováno v:
Anesthesia & Analgesia. 119:1232-1234
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fd41af1772b300cb958a5b3b16290a46
https://doi.org/10.1213/ane.0000000000000484
https://doi.org/10.1213/ane.0000000000000484
Autor:
Edmond I. Eger
Publikováno v:
Canadian Journal of Anesthesia/Journal canadien d'anesthésie. 61:76-79
From the discovery of anesthesia in 1846 until the 1960s, anesthetic investigations focused largely on the management of clinical problems. The 1960s saw increasing attention to the dose-related effects of anesthesia on the vital processes of the bod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e08f6fda4cb3af450d9c24da60aa56f7
https://doi.org/10.1007/s12630-013-0060-2
https://doi.org/10.1007/s12630-013-0060-2
Autor:
Robert A. Pearce, Misha Perouansky, Tim Ford, Vinuta Rau, S. Irene Oh, Edmond I. Eger, Mark Perkins
Publikováno v:
Anesthesiology. 113:1299-1309
Background Temporary, antegrade amnesia is one of the core desirable endpoints of general anesthesia. Multiple lines of evidence support a role for the hippocampal θ rhythm, a synchronized rhythmic oscillation of field potentials at 4-12 Hz, in memo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::826e7e2ba2118c31e99ecda3bb799ceb
https://doi.org/10.1097/aln.0b013e3181f90ccc
https://doi.org/10.1097/aln.0b013e3181f90ccc
Autor:
Irene Oh, R. A. Harris, Mandy L. McCracken, Cecilia M. Borghese, M. S. Fanselow, Edmond I. Eger, David F. Werner, J. M. Sonner, Neil L. Harrison, Sangeetha Iyer, F. Jia, Vinuta Rau, A. Swihart, Gregg E. Homanics
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 336:134-144
The mechanism by which the inhaled anesthetic isoflurane produces amnesia and immobility is not understood. Isoflurane modulates GABA(A) receptors (GABA(A)-Rs) in a manner that makes them plausible targets. We asked whether GABA(A)-R α2 subunits con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::291019ae058211cdda1569f7c439deec
https://doi.org/10.1124/jpet.110.170431
https://doi.org/10.1124/jpet.110.170431
Autor:
II Edmond I Eger
Publikováno v:
Anesthesiology. 112:786-793
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6486588651899fdc7af87c9132fd6485
https://doi.org/10.1097/aln.0b013e3181d40f47
https://doi.org/10.1097/aln.0b013e3181d40f47
Publikováno v:
Behavioural Brain Research. 193:192-196
The molecular site of action for volatile anesthetics remains unknown despite many years of study. Members of the K2P potassium channel family, whose currents are potentiated by volatile anesthetics have emerged as possible anesthetic targets. In fac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f57df4fdabf2949e1131dece588a813f
https://doi.org/10.1016/j.bbr.2008.05.010
https://doi.org/10.1016/j.bbr.2008.05.010
Autor:
R. Adron Harris, Edmond I. Eger, Yi Zhang, Hugh C. Hemmings, Michael J. Laster, Manohar Sharma
Publikováno v:
Anesthesia & Analgesia. 107:875-878
Results from several studies point to sodium channels as potential mediators of the immobility produced by inhaled anesthetics. We hypothesized that the intrathecal administration of veratridine, a drug that enhances the activity or effect of sodium
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c05f77bd5284e575d9cd3bf079f2e44
https://doi.org/10.1213/ane.0b013e3181815fbc
https://doi.org/10.1213/ane.0b013e3181815fbc
Publikováno v:
Anesthesia & Analgesia. 107:832-848
A paradox arises from present information concerning the mechanism(s) by which inhaled anesthetics produce immobility in the face of noxious stimulation. Several findings, such as additivity, suggest a common site at which inhaled anesthetics act to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::521a6704dec692043f102856f6461d7d
https://doi.org/10.1213/ane.0b013e318182aedb
https://doi.org/10.1213/ane.0b013e318182aedb