Výsledky vyhledávání - "Edmond Dik Lung Ma"

The anti-cancer agent SU4312 unexpectedly protects against MPP+-induced neurotoxicity via selective and direct inhibition of neuronal NOS

Autor: Wei Cui, Zhi-Xiu Lin, Yifan Han, Shengquan Hu, Zaijun Zhang, Huan Zhang, Fei Sa, Tony Chunglit Choi, Sai Li, Daping Xu, Simon My Lee, Edmond Dik Lung Ma, Zhong Zuo, Renwen Han, Jianhui Rong, Shinghung Mak, Wenming Li, Shuai Yuan

Publikováno v: British Journal of Pharmacology. 168:1201-1214

Background and Purpose SU4312, a potent and selective inhibitor of VEGF receptor-2 (VEGFR-2), has been designed to treat cancer. Recent studies have suggested that SU4312 can also be useful in treating neurodegenerative disorders. In this study, we a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::75ee8e354847e3e3137cf04c9f757bc1
https://doi.org/10.1111/bph.12004

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Substantial protection against MPTP-associated Parkinson's neurotoxicity in vitro and in vivo by anti-cancer agent SU4312 via activation of MEF2D and inhibition of MAO-B

Autor: Tony Chunglit Choi, Yuqiang Wang, Edmond Dik Lung Ma, Baojian Guo, Shinghung Mak, Yifan Han, Fangcheng Luo, Guozhen Cui, Chengyou Zheng, Shengquan Hu, Simon Ming-Yuen Lee, Hongyu Wang, Xifei Yang, Haitao Li, Wei Cui, Zaijun Zhang

Publikováno v: Neuropharmacology. 126

We have previously demonstrated the unexpected neuroprotection of the anti-cancer agent SU4312 in cellular models associated with Parkinson's disease (PD). However, the precise mechanisms underlying its neuroprotection are still unknown, and the effe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::693809fc06272acf4d742c412c9a4a10
https://pubmed.ncbi.nlm.nih.gov/28807675

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Protection against β-amyloid-induced synaptic and memory impairments via altering β-amyloid assembly by bis(heptyl)-cognitin

Autor: Yuan Ping Pang, Tony Chunglit Choi, Yifan Han, Shujun Xu, Qinwen Wang, Edmond Dik Lung Ma, Victor Pui-Yan Ma, Hongjun Fu, Shengquan Hu, Liang Tao, Juwei Hu, Wenhua Zhou, Roger Anwyl, Michael J. Rowan, Yong Yang, Wei Cui, Lan Chang, Shinghung Mak, Qin Wang

Publikováno v: Scientific Reports

β-amyloid (Aβ) oligomers have been closely implicated in the pathogenesis of Alzheimer’s disease (AD). We found, for the first time, that bis(heptyl)-cognitin, a novel dimeric acetylcholinesterase (AChE) inhibitor derived from tacrine, prevented

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37b59c9e3bffe3c1c4860f994227179d

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The anti-cancer agent SU4312 unexpectedly protects against MPP(+) -induced neurotoxicity via selective and direct inhibition of neuronal NOS

Autor: Wei, Cui, Zaijun, Zhang, Wenming, Li, Shengquan, Hu, Shinghung, Mak, Huan, Zhang, Renwen, Han, Shuai, Yuan, Sai, Li, Fei, Sa, Daping, Xu, Zhixiu, Lin, Zhong, Zuo, Jianhui, Rong, Edmond Dik-Lung, Ma, Tony Chunglit, Choi, Simon My, Lee, Yifan, Han

Publikováno v: British journal of pharmacology. 168(5)

SU4312, a potent and selective inhibitor of VEGF receptor-2 (VEGFR-2), has been designed to treat cancer. Recent studies have suggested that SU4312 can also be useful in treating neurodegenerative disorders. In this study, we assessed neuroprotection

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1ea380e84e2631da14f7c70d87a34853
https://pubmed.ncbi.nlm.nih.gov/23062100

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