ENGRAILED-1 transcription factor has a paracrine neurotrophic activity on adult spinal α-motoneurons

Autor: Mélanie Lebœuf, Stephanie E. Vargas-Abonce, Eugénie Pezé-Hedsieck, Edmond Dupont, Lucia Jimenez-Alonso, Kenneth L. Moya, Alain Prochiantz

Several homeoprotein transcription factors transfer between cells and regulate gene expression, protein translation, and chromatin organization in recipient cells. ENGRAILED-1 is one such homeoprotein expressed in spinal V1 interneurons synapsing on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b46529d97645cb5d5cda8dba94a942a4
https://doi.org/10.1101/2022.08.16.504081

Bidirectional transfer of Engrailed homeoprotein across the plasma membrane requires PIP2

Autor: Julie Miralvès, Alain Joliot, Irène Amblard, Isabelle Queguiner, Isabel D. Alves, Edmond Dupont

Publikováno v: Journal of Cell Science
Journal of Cell Science, Company of Biologists, 2020, ⟨10.1101/2020.01.21.913566⟩

1.AbstractHomeoproteins are a class of transcription factors sharing the unexpected property of intercellular trafficking. It confers to homeoproteins a paracrine mode of action, shown to exert a wide range of physiological functions, during developm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41faf63e28634feb8384dff5692a9b4c
https://hal.archives-ouvertes.fr/hal-03082837/document

Control of brain patterning by Engrailed paracrine transfer: a new function of the Pbx interaction domain

Autor: Thomas Le Saux, Alain Joliot, Sophie Vriz, Adrien Cosson, Alice Frerot, Francesca Meda, Isabelle Aujard, David Bensimon, Thibault Lin, Michel Volovitch, Ludovic Jullien, Edmond Dupont, Eliane Ipendey, Carole Gauron, Christine Rampon

Publikováno v: Development (Cambridge, England)

Homeoproteins of the Engrailed family are involved in the patterning of mesencephalic boundaries through a mechanism classically ascribed to their transcriptional functions. In light of recent reports on the paracrine activity of homeoproteins, inclu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af34f39421e8b05d7b53a48d4699b6bc
https://doi.org/10.1242/dev.114181

Homeoproteins and Homeoprotein-derived Peptides: Going in and Out

Autor: Alain Joliot, Edmond Dupont, Cherine Bechara, Sandrine Sagan, Fabienne Burlina, Isabel D. Alves

Publikováno v: Current Pharmaceutical Design
Current Pharmaceutical Design, 2012, 19 (16), pp.2851-2862. ⟨10.2174/1381612811319160002⟩
Current Pharmaceutical Design, Bentham Science Publishers, 2012, 19 (16), pp.2851-2862. ⟨10.2174/1381612811319160002⟩

International audience; Since the initial evidence that antennapedia homeobox[1] can cross cell membranes and internalize into cells, numerous peptides with similar translocation properties have been described. These peptides are referred to as cell-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3754d457dbf24007f8a2402e74d73b95
https://doi.org/10.2174/1381612811319160002

Subcellular redox manipulation identifies H 2 O 2 as a key signaling molecule in cell behaviour

Autor: Michel Volovitch, Alain Joliot, Sophie Vriz, Edmond Dupont, Marion Thauvin, Francesca Meda, Isabelle Queguiner, Christine Rampon

Publikováno v: Free Radical Biology and Medicine. 120:S58

Accumulation of reactive oxygen species (ROS) in cells, referred to as oxidative stress, has a direct toxic impact on a number of biomolecules (proteins, lipids and nucleic acids). However, recent findings have shown that ROS can also contribute to b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::67ab5b4ce633df00c419c1693b91d2dd
https://doi.org/10.1016/j.freeradbiomed.2018.04.192