Associations Between Polygenic Risk Score Loading, Psychosis Liability, and Clozapine Use Among Individuals With Schizophrenia

Autor: Lin, Bochao D., Pinzón-Espinosa, Justo, Blouzard, Elodie, Van Der Horst, Marte Z., Okhuijsen-pfeifer, Cynthia, Van Eijk, Kristel R., Guloksuz, Sinan, Peyrot, Wouter J., Luykx, Jurjen J., Hasan, Alkomiet, Wagner, Elias, Pantelis, Christos, Everall, Ian P., Ayhan, Y., Babaoğlu, M. O., Bak, Maarten, Alink, Wouter, Beld, E, Bouhuis, A, Edlinger, M, Erdoğan, I .m., Gutwinski, Stefan, Hallikainen, Tero, Jeger-land, E, Lähteenvuo, Markku, De Koning, Mariken B., Morgenroth, Carla, Müderrisoğlu, A., Oviedo-salcedo, Tatiana, Schreiter, Stefanie, Repo-tiihonen, Eila, Tuppurainen, Heli, Veereschild, Mike, Veerman, Selene R.t., Cohen, Dan, De Vos, M, Bogers, Jan P.a.m., Anıl Yağcıoğlu, A.e., Tiihonen, Jari, Ripke, Stephan, Bousman, Chad A., Van Beek, H, Van Der Horst, Marte, Van Eijk, Kristel, Ertuğrul, A., Yoca, G., Görlitz, T., Grootens, K., Leucht, Stefan, Narang, A., Schneider-thoma, J., Kahn, René S., Bekema, Erwin, Kleymann, Phillip, Alizadeh, Behrooz Z., Van Amelsvoort, Therese, Cahn, Wiepke, De Haan, Lieuwe, Schirmbeck, Frederike, Simons, Claudia J.p., Van Os, Jim, Rutten, Bart, Van Winkel, Ruud

Publikováno v: JAMA Psychiatry. American Medical Association
Genetic Risk and Outcome of Psychosis (GROUP) and Clozapine International Consortium (CLOZIN) Investigators 2023, ' Associations Between Polygenic Risk Score Loading, Psychosis Liability, and Clozapine Use Among Individuals With Schizophrenia ', JAMA Psychiatry, vol. 80, no. 2, pp. 181-185 . https://doi.org/10.1001/jamapsychiatry.2022.4234
JAMA psychiatry, 80(2), 181-185. American Medical Association
JAMA Psychiatry, 80(2), 181-185. American Medical Association
Genetic Risk and Outcome of Psychosis (GROUP) and Clozapine International Consortium (CLOZIN) Investigators 2023, ' Associations Between Polygenic Risk Score Loading, Psychosis Liability, and Clozapine Use Among Individuals With Schizophrenia ', JAMA psychiatry, vol. 80, no. 2, pp. 181-185 . https://doi.org/10.1001/jamapsychiatry.2022.4234

ImportancePredictors consistently associated with psychosis liability and course of illness in schizophrenia (SCZ) spectrum disorders (SSD), including the need for clozapine treatment, are lacking. Longitudinally ascertained medication use may empowe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10b30808f0062dc9476f2ac63918f219
http://www.scopus.com/inward/record.url?scp=85147317982&partnerID=8YFLogxK

Genome-wide association analyses of symptom severity among clozapine-treated patients with schizophrenia spectrum disorders

Autor: Okhuijsen-Pfeifer, C., van der Horst, M. Z., Bousman, C. A., Lin, B., van Eijk, K. R., Ripke, S., Ayhan, Y., Babaoglu, M. O., Bak, M., Alink, W., van Beek, H., Beld, E., Bouhuis, A., Edlinger, M., Erdogan, I. M., Ertuğrul, A., Yoca, G., Everall, I. P., Görlitz, T., van Amelsvoort, T., Bartels-Velthuis, A. A., Bruggeman, R., Cahn, W., Guloksuz, S., de Haan, L., Kahn, R. S., Schirmbeck, F., Simons, C. J. P., van Os, J., Alizadeh, B. Z., Luykx, J. J., Rutten, B. P. F., van Winkel, R., Grootens, K. P., Gutwinski, S., Hallikainen, T., Jeger-Land, E., de Koning, M., Lähteenvuo, M., Legge, S. E., Leucht, S., Morgenroth, C., Müderrisoğlu, A., Narang, A., Pantelis, C., Pardiñas, A. F., Oviedo-Salcedo, T., Schneider-Thoma, J., Schreiter, S., Repo-Tiihonen, E., Tuppurainen, H., Veereschild, M., Veerman, S., de Vos, M., Wagner, E., Cohen, D., Bogers, J. P. A. M., Walters, J. T. R., Yağcıoğlu, A. E. Anil, Tiihonen, J., Hasan, A.

Publikováno v: Translational Psychiatry, 12(1):145. Nature Publishing Group
Translational psychiatry, 12(1):145. Nature Publishing Group

Clozapine is the most effective antipsychotic for patients with treatment-resistant schizophrenia. However, response is highly variable and possible genetic underpinnings of this variability remain unknown. Here, we performed polygenic risk score (PR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15d35979803fbaf570d9245558fcc0da
https://research.rug.nl/en/publications/68c11f0b-1d30-47b1-b8cc-469ae7b6003c

High-quality endoscope reprocessing decreases endoscope contamination

Autor: Decristoforo, P. ^†, Kaltseis, J. ^†, Fritz, A., Edlinger, M., Posch, W., Wilflingseder, D., Lass-Flörl, C., Orth-Höller, D.

Publikováno v: In Clinical Microbiology and Infection October 2018 24(10):1101-1101

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