Acute suppression of mitochondrial ATP production prevents apoptosis and provides an essential signal for NLRP3 inflammasome activation.

Autor: Saller BS; Institute of Neuropathology, Faculty of Medicine, Medical Center, University of Freiburg, Freiburg, Germany; Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany., Wöhrle S; Institute of Neuropathology, Faculty of Medicine, Medical Center, University of Freiburg, Freiburg, Germany; Faculty of Biology, University of Freiburg, Freiburg, Germany., Fischer L; Institute of Neuropathology, Faculty of Medicine, Medical Center, University of Freiburg, Freiburg, Germany; Faculty of Biology, University of Freiburg, Freiburg, Germany., Dufossez C; Institute of Neuropathology, Faculty of Medicine, Medical Center, University of Freiburg, Freiburg, Germany; Faculty of Biology, University of Freiburg, Freiburg, Germany., Ingerl IL; Institute of Neuropathology, Faculty of Medicine, Medical Center, University of Freiburg, Freiburg, Germany., Kessler S; Institute of Virology, Faculty of Medicine, Medical Center, University of Freiburg, Freiburg, Germany., Mateo-Tortola M; Department of Innate Immunity, Institute of Immunology, University of Tübingen, Tübingen, Germany., Gorka O; Institute of Neuropathology, Faculty of Medicine, Medical Center, University of Freiburg, Freiburg, Germany., Lange F; Research Group Mitochondrial Structure and Dynamics, Department of NanoBiophotonics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany; Clinic for Neurology, University Medical Center of Göttingen, Göttingen, Germany., Cheng Y; Institute of Genetic Epidemiology, Faculty of Medicine, Medical Center, University of Freiburg, Freiburg, Germany., Neuwirt E; Institute of Neuropathology, Faculty of Medicine, Medical Center, University of Freiburg, Freiburg, Germany; Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany., Marada A; Institute of Biochemistry and Molecular Biology, ZBMZ, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Koentges C; Institute of Neuropathology, Faculty of Medicine, Medical Center, University of Freiburg, Freiburg, Germany., Urban C; Institute of Neuropathology, Faculty of Medicine, Medical Center, University of Freiburg, Freiburg, Germany., Aktories P; Institute of Neuropathology, Faculty of Medicine, Medical Center, University of Freiburg, Freiburg, Germany; Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany; Faculty of Biology, University of Freiburg, Freiburg, Germany., Reuther P; Institute of Virology, Faculty of Medicine, Medical Center, University of Freiburg, Freiburg, Germany., Giese S; Institute of Virology, Faculty of Medicine, Medical Center, University of Freiburg, Freiburg, Germany., Kirschnek S; Institute of Medical Microbiology and Hygiene, Faculty of Medicine, Medical Center, University of Freiburg, Freiburg, Germany., Mayer C; Institute of Medical Microbiology and Hygiene, Faculty of Medicine, Medical Center, University of Freiburg, Freiburg, Germany., Pilic J; Gottfried Schatz Research Center, Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria., Falquez-Medina H; Institute of Biochemistry and Molecular Biology, ZBMZ, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Veterinary Physiological Chemical Institute, Faculty of Veterinary Medicine, University of Leipzig, Leipzig, Germany., Oelgeklaus A; Institute of Biochemistry and Molecular Biology, ZBMZ, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Veterinary Physiological Chemical Institute, Faculty of Veterinary Medicine, University of Leipzig, Leipzig, Germany., Deepagan VG; The Walter and Eliza Hall Institute of Medical Research, The Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia., Shojaee F; The Walter and Eliza Hall Institute of Medical Research, The Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia., Zimmermann JA; Department of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany., Weber D; Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany; Internal Medicine IV, Faculty of Medicine, Medical Center, University of Freiburg, Freiburg, Germany., Tai YH; Institute of Clinical Neuroimmunology, University Hospital, Ludwig-Maximilians Universität München, Munich, Germany; Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians Universität München, Martinsried, Germany; Institute of Neuronal Cell Biology, Technical University of Munich, Munich, Germany., Crois A; Faculty of Biology, University of Freiburg, Freiburg, Germany; Institute for Molecular Medicine and Cell Research, ZBMZ, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Ciminski K; Institute of Virology, Faculty of Medicine, Medical Center, University of Freiburg, Freiburg, Germany., Peyronnet R; Institute for Experimental Cardiovascular Medicine, Faculty of Medicine, University Heart Center Freiburg - Bad Krozingen, University of Freiburg, Freiburg, Germany., Brandenburg KS; Institute of Neuropathology, Faculty of Medicine, Medical Center, University of Freiburg, Freiburg, Germany., Wu G; Bioinformatics and Molecular Genetics, Faculty of Biology, University of Freiburg, Freiburg, Germany., Baumeister R; Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany; Institute of Biochemistry and Molecular Biology, ZBMZ, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Bioinformatics and Molecular Genetics, Faculty of Biology, University of Freiburg, Freiburg, Germany., Heimbucher T; Bioinformatics and Molecular Genetics, Faculty of Biology, University of Freiburg, Freiburg, Germany., Rizzi M; Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany; Department of Rheumatology and Clinical Immunology and Center for Chronic Immunodeficiency, Faculty of Medicine, Medical Center, University of Freiburg, Freiburg, Germany; Division of Clinical and Experimental Immunology, Institute of Immunology, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria., Riedel D; Laboratory for Electron Microscopy, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany., Helmstädter M; EMcore, Internal Medicine IV, Faculty of Medicine, Medical Center, University of Freiburg, Freiburg, Germany., Buescher J; Metabolomics and FACS Core Facilities, Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany., Neumann K; Institute of Clinical Chemistry, Hannover Medical School, Hannover, Germany., Misgeld T; Institute of Neuronal Cell Biology, Technical University of Munich, Munich, Germany; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Kerschensteiner M; Institute of Clinical Neuroimmunology, University Hospital, Ludwig-Maximilians Universität München, Munich, Germany; Biomedical Center (BMC), Faculty of Medicine, Ludwig-Maximilians Universität München, Martinsried, Germany; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Walentek P; Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany; Internal Medicine IV, Faculty of Medicine, Medical Center, University of Freiburg, Freiburg, Germany., Kreutz C; Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany; Institute of Medical Biometry and Statistics, Faculty of Medicine, Medical Center, University of Freiburg, Freiburg, Germany., Maurer U; Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany; Institute for Molecular Medicine and Cell Research, ZBMZ, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Rambold AS; Department of Developmental Immunology, Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany., Vince JE; The Walter and Eliza Hall Institute of Medical Research, The Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia., Edlich F; Institute of Biochemistry and Molecular Biology, ZBMZ, Faculty of Medicine, University of Freiburg, Freiburg, Germany; Veterinary Physiological Chemical Institute, Faculty of Veterinary Medicine, University of Leipzig, Leipzig, Germany., Malli R; Gottfried Schatz Research Center, Molecular Biology and Biochemistry, Medical University of Graz, Graz, Austria., Häcker G; Institute of Medical Microbiology and Hygiene, Faculty of Medicine, Medical Center, University of Freiburg, Freiburg, Germany., Kierdorf K; Institute of Neuropathology, Faculty of Medicine, Medical Center, University of Freiburg, Freiburg, Germany; Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany., Meisinger C; Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany; Institute of Biochemistry and Molecular Biology, ZBMZ, Faculty of Medicine, University of Freiburg, Freiburg, Germany., Köttgen A; Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany; Institute of Genetic Epidemiology, Faculty of Medicine, Medical Center, University of Freiburg, Freiburg, Germany., Jakobs S; Research Group Mitochondrial Structure and Dynamics, Department of NanoBiophotonics, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany; Clinic for Neurology, University Medical Center of Göttingen, Göttingen, Germany; Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Translational Neuroinflammation and Automated Microscopy TNM, Göttingen, Germany., Weber ANR; Department of Innate Immunity, Institute of Immunology, University of Tübingen, Tübingen, Germany; Clusters of Excellence EXC-2180 (iFIT) and -2124 (CMFI), University of Tübingen, Tübingen, Germany., Schwemmle M; Institute of Virology, Faculty of Medicine, Medical Center, University of Freiburg, Freiburg, Germany., Groß CJ; Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany., Groß O; Institute of Neuropathology, Faculty of Medicine, Medical Center, University of Freiburg, Freiburg, Germany; Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany. Electronic address: olaf.gross@uniklinik-freiburg.de.

Publikováno v: Immunity [Immunity] 2024 Nov 15. Date of Electronic Publication: 2024 Nov 15.

Kill one or kill the many: interplay between mitophagy and apoptosis.

Autor: Wanderoy S; Max Planck Institute for Neurobiology, Am Klopferspitz 18, D-82152Martinsried, Germany., Hees JT; Max Planck Institute for Neurobiology, Am Klopferspitz 18, D-82152Martinsried, Germany., Klesse R; Institute for Biochemistry and Molecular Biology, University of Freiburg, D-79104Freiburg, Germany.; Faculty of Biology, University of Freiburg, D-79104Freiburg, Germany., Edlich F; Institute for Biochemistry and Molecular Biology, University of Freiburg, D-79104Freiburg, Germany., Harbauer AB; Max Planck Institute for Neurobiology, Am Klopferspitz 18, D-82152Martinsried, Germany.; Technical University of Munich, Institute of Neuronal Cell Biology, Munich, Germany.; Munich Cluster for Systems Neurology, Munich, Germany.

Publikováno v: Biological chemistry [Biol Chem] 2020 Oct 12; Vol. 402 (1), pp. 73-88. Date of Electronic Publication: 2020 Oct 12 (Print Publication: 2020).

Chlamydia trachomatis inhibits apoptosis in infected cells by targeting the pro-apoptotic proteins Bax and Bak.

Autor: Waguia Kontchou C; Institute of Medical Microbiology and Hygiene, Medical Center - University of Freiburg, Faculty of Medicine, 79104, Freiburg, Germany., Gentle IE; Institute of Medical Microbiology and Hygiene, Medical Center - University of Freiburg, Faculty of Medicine, 79104, Freiburg, Germany., Weber A; Institute of Medical Microbiology and Hygiene, Medical Center - University of Freiburg, Faculty of Medicine, 79104, Freiburg, Germany., Schoeniger A; Veterinary Physiological Chemical Institute, Faculty of Veterinary Medicine, University of Leipzig, 04103, Leipzig, Germany., Edlich F; Veterinary Physiological Chemical Institute, Faculty of Veterinary Medicine, University of Leipzig, 04103, Leipzig, Germany., Häcker G; Institute of Medical Microbiology and Hygiene, Medical Center - University of Freiburg, Faculty of Medicine, 79104, Freiburg, Germany. georg.haecker@uniklinik-freiburg.de.; BIOSS Centre for Biological Signalling Studies, University of Freiburg, 79104, Freiburg, Germany. georg.haecker@uniklinik-freiburg.de.

Publikováno v: Cell death and differentiation [Cell Death Differ] 2022 Oct; Vol. 29 (10), pp. 2046-2059. Date of Electronic Publication: 2022 Apr 09.

Hexokinases inhibit death receptor-dependent apoptosis on the mitochondria.

Autor: Lauterwasser J; Institute for Biochemistry and Molecular Biology, Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany., Fimm-Todt F; Institute for Biochemistry and Molecular Biology, Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany., Oelgeklaus A; Institute for Biochemistry and Molecular Biology, Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany.; Veterinary Physiological Chemical Institute, Faculty of Veterinary Medicine, University of Leipzig, 04103 Leipzig, Germany.; Spemann Graduate School of Biology and Medicine, 79104 Freiburg, Germany.; Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany., Schreiner A; Institute for Biochemistry and Molecular Biology, Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany., Funk K; Institute for Biochemistry and Molecular Biology, Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany.; Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany., Falquez-Medina H; Institute for Biochemistry and Molecular Biology, Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany.; Veterinary Physiological Chemical Institute, Faculty of Veterinary Medicine, University of Leipzig, 04103 Leipzig, Germany., Klesse R; Institute for Biochemistry and Molecular Biology, Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany.; Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany., Jahreis G; Institute for Biochemistry and Biotechnology, University of Halle, 06120 Halle, Germany., Zerbes RM; Institute for Biochemistry and Molecular Biology, Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany., O'Neill K; Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198.; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198., van der Laan M; Institute for Biochemistry and Molecular Biology, Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany.; Medical Biochemistry and Molecular Biology, Saarland University, D-66421 Homburg, Germany., Luo X; Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198.; Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE 68198., Edlich F; Institute for Biochemistry and Molecular Biology, Faculty of Medicine, University of Freiburg, 79104 Freiburg, Germany; frank.edlich@uni-leipzig.de.; Veterinary Physiological Chemical Institute, Faculty of Veterinary Medicine, University of Leipzig, 04103 Leipzig, Germany.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Aug 17; Vol. 118 (33).

Pharmacological Preconditioning with Fenofibrate in Cardiomyocyte Cultures of Neonatal Rats Subjected to Hypoxia/Reoxygenation, High Glucose, and Their Combination.

Autor: Oidor-Chan, Víctor Hugo¹ (AUTHOR) victorhugooidor@xanum.uam.mx, Sánchez-López, Araceli² (AUTHOR) asanchezl@cinvestav.mx, Cano-Martinez, Agustina³ (AUTHOR) agustina.cano@cardiologia.org.mx, García-Niño, Willy Ramses⁴ (AUTHOR) ramses.garcia@cardiologia.org.mx, Soria-Castro, Elizabeth⁴ (AUTHOR) elizabeth.soria@cardiologia.org.mx, del Valle-Mondragón, Leonardo⁵ (AUTHOR) leonardo.delvalle@cardiologia.org.mx, Zarco-Olvera, Gabriela⁵ (AUTHOR) gabriela.zarco@cardiologia.org.mx, Patlán, Mariana⁶ (AUTHOR) mariana.patlan@cardiologia.org.mx, Guarner-Lans, Veronica³ (AUTHOR) veronica.guarner@cardiologia.org.mx, Rodríguez-Maldonado, Emma⁷ (AUTHOR) emma.rodriguez@cardiologia.org.mx, Flores-Estrada, Javier⁸ (AUTHOR) jose.florese@salud.gob.mx, Castrejón-Téllez, Vicente³ (AUTHOR) vicente.castrejon@cardiologia.org.mx, Ibarra-Lara, Luz⁵ (AUTHOR) vicente.castrejon@cardiologia.org.mx

Publikováno v: International Journal of Molecular Sciences. Nov2024, Vol. 25 Issue 21, p11391. 21p.