Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Edlaine Lucien"'
Autor:
Akihiro Hashimoto, Barton James Bradbury, Qiuping Wang, Jason Allan Wiles, Christopher D. Incarvito, Godwin C. G. Pais, Edlaine Lucien, Milind Deshpande
Publikováno v:
Organic Process Research & Development. 11:389-398
We report the synthesis of the new 2-sulfonylquinolone ethyl 1-cyclopropyl-6,7-difluoro-2-methanesulfonyl-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylate (5). Sulfone 5 is a key intermediate used in the optimized synthesis of the isothiazoloquinol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c58f7746838b935f2ceb4037f70e92e1
https://doi.org/10.1021/op700014t
https://doi.org/10.1021/op700014t
Autor:
Akihiro Hashimoto, Christy L. Thoma, Steven D. Podos, Christopher W. Marlor, Michael J. Pucci, Jijun Cheng, Jane A. Thanassi, Milind Deshpande, Yongsheng Song, Qiuping Wang, Jason Allan Wiles, Edlaine Lucien, Barton James Bradbury, Yangsi Ou
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:1277-1281
We synthesized a diverse series of 9H-isothiazolo[5,4-b]quinoline-3,4-diones containing heteroaromatic groups at the 7-position via palladium-catalyzed cross-coupling. Many of these compounds demonstrated potent antistaphylococcal activity (MICs ⩽2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f71a4a489eb021a9ac669904fdc62c44
https://doi.org/10.1016/j.bmcl.2005.11.064
https://doi.org/10.1016/j.bmcl.2005.11.064
Autor:
Steven D. Podos, Milind Deshpande, David M. Nelson, Barton James Bradbury, Akihiro Hashimoto, Ha Young Kim, Godwin Pais, Jane A. Thanassi, Qiuping Wang, Jason Allan Wiles, Michael J. Pucci, Edlaine Lucien
Publikováno v:
Journal of medicinal chemistry. 54(9)
A series of 7-(3'-substituted)pyrrolidino-8-methoxyisothiazoloquinolone (ITQ) analogues were prepared, and their antibacterial potency against methicillin-sensitive Staphylococcus aureus (MSSA), methicillin-resistant Staphylococcus aureus (MRSA), and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efb93fbdd00801990fc5bad0f2c47fcc
https://pubmed.ncbi.nlm.nih.gov/21425851
https://pubmed.ncbi.nlm.nih.gov/21425851
Autor:
Douglas D. Buechter, Jane A. Thanassi, David M. Nelson, Christopher W. Marlor, Barton James Bradbury, Qiuping Wang, Jason Allan Wiles, Michael J. Pucci, Yongsheng Song, Edlaine Lucien, Akihiro Hashimoto, Christy L. Thoma, Jijun Cheng, Godwin Pais, Steven D. Podos, Milind Deshpande, Yangsi Ou
Publikováno v:
Journal of medicinal chemistry. 50(2)
We describe the biological evaluation of isothiazoloquinolones (ITQs) having structural modifications at the 6-, 7-, and 8-positions. Addition of a methoxy substituent to C-8 effected an increase in antibacterial activity against methicillin-resistan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e53982831711cb8c6af9ea3dcbc17c64
https://pubmed.ncbi.nlm.nih.gov/17228862
https://pubmed.ncbi.nlm.nih.gov/17228862
Autor:
Yangsi Ou, Edlaine Lucien, Michael J. Pucci, Jijun Cheng, Steven D. Podos, Christy L. Thoma, Christopher W. Marlor, Yongsheng Song, Milind Deshpande, Jane A. Thanassi, Qiuping Wang, Jason Allan Wiles, Barton James Bradbury, Akihiro Hashimoto
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(5)
This report describes 9H-isothiazolo[5,4-b]quinoline-3,4-diones (ITQs) containing aromatic groups at the 7-position that were prepared using palladium-catalyzed cross-coupling and tested against a panel of susceptible and resistant bacteria. In gener
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d958514ec86459db0fbf7ec7efb2023a
https://pubmed.ncbi.nlm.nih.gov/16337791
https://pubmed.ncbi.nlm.nih.gov/16337791
Autor:
Qiuping Wang, Edlaine Lucien, Akihiro Hashimoto, Godwin C. G. Pais, David M. Nelson, Yongsheng Song, Jane A. Thanassi, Christopher W. Marlor, Christy L. Thoma, Jijun Cheng, Steven D. Podos, Yangsi Ou, Milind Deshpande, Michael J. Pucci, Douglas D. Buechter, Barton J. Bradbury, Jason A. Wiles
Publikováno v:
Journal of Medicinal Chemistry; Jan2007, Vol. 50 Issue 2, p199-210, 12p