Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Edith Zuniga"'
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Tumors evolve a variety of mechanisms to escape immune detection while expressing tumor-promoting molecules that can be immunogenic. Here, we show that transposable elements (TE) and gene encoded, tumor-associated antigens (TAA), which can be both hi
Externí odkaz:
https://doaj.org/article/8fec213f092f42c5938bf108cdf9a23a
Autor:
Nancy D. Ebelt, Edith Zuniga, Monica Marzagalli, Vic Zamloot, Bruce R. Blazar, Ravi Salgia, Edwin R. Manuel
Publikováno v:
Biomedicines, Vol 8, Iss 12, p 617 (2020)
Therapeutic options for non-small cell lung cancer (NSCLC) treatment have changed dramatically in recent years with the advent of novel immunotherapeutic approaches. Among these, immune checkpoint blockade (ICB) using monoclonal antibodies has shown
Externí odkaz:
https://doaj.org/article/e6ed696cdf6246b3a3e188ae25db54a2
Supplementary Table 1 describes the parental strains and mutations used to generate attenuated ST strains.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d24cf134948b1439ffff79bf9e7496b6
https://doi.org/10.1158/1535-7163.22521696.v1
https://doi.org/10.1158/1535-7163.22521696.v1
Supplementary Figure 1 describes BHs expression in uninduced ST strains as well as the predicted localization of BHs. Viability of bHs-expressing ST strains is analyzed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dd83218aa5660badf38f9ce1859f270
https://doi.org/10.1158/1535-7163.22521708.v1
https://doi.org/10.1158/1535-7163.22521708.v1
Supplementary Figure 2 describes the ability of X8768-BHs to degrade HA from fixed human PC-3 prostate cancer cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58abaa774f3613c06c3724df0a56b824
https://doi.org/10.1158/1535-7163.22521705
https://doi.org/10.1158/1535-7163.22521705
Supplementary Figure 3 describes the ability of X8768 expressing bacterial luciferase to colonize tumors and peripheral tissues, as well as how HA degradation affects vasculature in PANC-1 tumors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f45c63d49420eb6a8098ea2e27e9638
https://doi.org/10.1158/1535-7163.22521702.v1
https://doi.org/10.1158/1535-7163.22521702.v1
Supplementary Figure 4 shows that treatment with X8768-BHs does not degrade HA is non-tumor tissues, and does not affaect total cellular content of tumor tissue where HA was degraded.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d5b95c6a78dc9c8c7d3d6239af2e819
https://doi.org/10.1158/1535-7163.22521699.v1
https://doi.org/10.1158/1535-7163.22521699.v1
Publikováno v:
Journal of the National Comprehensive Cancer Network. 18:YIA20-004
Publikováno v:
Molecular Cancer Therapeutics. 19:706-716
In pancreatic ductal adenocarcinoma (PDAC), the extracellular matrix (ECM) surrounding cancer cells forms a barrier that often limits the ability of chemotherapeutic drugs and cytotoxic immune subsets to penetrate and eliminate tumors. The dense stro
Autor:
Edith Zuniga, Kevin B Passi, Cari A Young, Edwin R. Manuel, Vic Zamloot, Lukas J Sobocinski, Bruce R. Blazar, Nancy D. Ebelt
Publikováno v:
Cancers
Volume 13
Issue 14
Cancers, Vol 13, Iss 3565, p 3565 (2021)
Volume 13
Issue 14
Cancers, Vol 13, Iss 3565, p 3565 (2021)
Therapeutic resistance in pancreatic ductal adenocarcinoma (PDAC) can be attributed, in part, to a dense extracellular matrix containing excessive collagen deposition. Here, we describe a novel Salmonella typhimurium (ST) vector expressing the bacter