Výsledky vyhledávání - "Edith Palmieri"

Akademický článek

Structure-guided development of a high-affinity human Programmed Cell Death-1: Implications for tumor immunotherapy

Autor: Eszter Lázár-Molnár, Lisa Scandiuzzi, Indranil Basu, Thomas Quinn, Eliezer Sylvestre, Edith Palmieri, Udupi A. Ramagopal, Stanley G. Nathenson, Chandan Guha, Steven C. Almo

Publikováno v: EBioMedicine, Vol 17, Iss C, Pp 30-44 (2017)

Programmed Cell Death-1 (PD-1) is an inhibitory immune receptor, which plays critical roles in T cell co-inhibition and exhaustion upon binding to its ligands PD-L1 and PD-L2. We report the crystal structure of the human PD-1 ectodomain and the mappi

Externí odkaz: https://doaj.org/article/3c7eab1bc1f246abbbcc754b857cc30a

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Structure-guided development of a high-affinity human Programmed Cell Death-1: Implications for tumor immunotherapy

Autor: Thomas J. Quinn, Eszter Lazar-Molnar, Chandan Guha, Indranil Basu, Steven C. Almo, Edith Palmieri, Eliezer Sylvestre, Stanley G. Nathenson, Udupi A. Ramagopal, Lisa Scandiuzzi

Publikováno v: EBioMedicine, Vol 17, Iss C, Pp 30-44 (2017)
EBioMedicine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73522bca8d582a148e97b65560d02861
http://www.sciencedirect.com/science/article/pii/S2352396417300622

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Predominant occupation of the class I MHC molecule H-2Kwm7 with a single self-peptide suggests a mechanism for its diabetes-protective effect

Autor: Stanley G. Nathenson, Vladimir N. Malashkevich, Udupi A. Ramagopal, Jeffrey Shabanowitz, Rodolfo J. Chaparro, Daniel R. Brims, Irene Jarchum, Steven C. Almo, Leann M. Mikesh, Edith Palmieri, Masakazu Hattori, Teresa P. DiLorenzo, Torben Lund, Jie Qian, Donald F. Hunt

Publikováno v: International Immunology. 22:191-203

Type 1 diabetes (T1D) is an autoimmune disease characterized by T cell-mediated destruction of insulin-producing pancreatic beta cells. In both humans and the non-obese diabetic (NOD) mouse model of T1D, class II MHC alleles are the primary determina

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b271644f8e5419b6f43354eeacb561a
https://doi.org/10.1093/intimm/dxp127

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T cell receptor binding kinetics required for T cell activation depend on the density of cognate ligand on the antigen-presenting cell

Autor: Jorge E. Mora, Stanley G. Nathenson, Leandro J. Carreño, Daniel Coombs, Pablo A. González, Byron Goldstein, Alexis M. Kalergis, Edith Palmieri

Publikováno v: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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CONICYT Chile
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CD8 + T cells recognize peptides of eight to nine amino acid residues long in the context of MHC class I molecules on the surface of antigen-presenting cells (APCs). This recognition event is highly sensitive, as evidenced by the fact that T cells ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13699a18bfa264d3778fa35aa08c2a9a
https://doi.org/10.1073/pnas.0500922102

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How H13 Histocompatibility Peptides Differing by a Single Methyl Group and Lacking Conventional MHC Binding Anchor Motifs Determine Self-Nonself Discrimination

Autor: Howard M. Grey, Nilabh Shastri, Derry C. Roopenian, David A. Ostrov, Darcie Tilley, Wuxian Shi, Stanley G. Nathenson, Gregory J. Christianson, Matthew M. Roden, Gilbert Villaflor, Lisa M. Mendoza, Steven C. Almo, Edith Palmieri

Publikováno v: The Journal of Immunology. 168:283-289

The mouse H13 minor histocompatibility (H) Ag, originally detected as a barrier to allograft transplants, is remarkable in that rejection is a consequence of an extremely subtle interchange, P4Val/Ile, in a nonamer H2-Db-bound peptide. Moreover, H13

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99d9b967199dd22dd1e2d03cd49add47
https://doi.org/10.4049/jimmunol.168.1.283

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Anin vitrostudy of the dynamic features of the major histocompatibility complex class I complex relevant to its role as a versatile peptide-receptive molecule

Autor: Ruth Hogue Angeletti, Stanley G. Nathenson, Zsuzsanna Vegh, Heidi Hörig, Nicholas J. Papadopoulos, Edith Palmieri

Publikováno v: Proceedings of the National Academy of Sciences. 94:13826-13831

The major histocompatibility complex class I complex consists of a heavy chain and a light chain (β2-microglobulin, β2m), which assemble with a short endogenously derived peptide in the endoplasmic reticulum. The class I peptide can be directly exc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36e560aceb89f1787f60440865d5f23b
https://doi.org/10.1073/pnas.94.25.13826

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A simplified procedure for the preparation of MHC/peptide tetramers: chemical biotinylation of an unpaired cysteine engineered at the C-terminus of MHC-I

Autor: Shinichiro Honda, Stanley G. Nathenson, Weijia Zhang, Alexis M. Kalergis, Edith Palmieri, Earl C. Goyarts

Publikováno v: Journal of immunological methods. 234(1-2)

Recently, a powerful approach for the detection of MHC/peptide-specific T cells has been made possible by the engineering of soluble-tetrameric MHC/peptide complexes, consisting of singly biotinylated MHC/peptide molecules bound to fluorescent-labele

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40e1a8d21fa1b7dbabf4bf4ac90e6dea
https://pubmed.ncbi.nlm.nih.gov/10669770

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