Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Edith Malecki"'
Autor:
Helmut Rosemeyer, Barbara Kaltschmidt, Malayko Montilla Martinez, Christian Kaltschmidt, Roland Brandt, Jürgen J. Heinisch, Lidia Bakota, Janine Müller, Maria Siemann, Katharina Raasch, Edith Malecki
Publikováno v:
Chemical Biology & Drug Design. 86:129-143
Nucleoside analogs (NSAs) were among the first chemotherapeutic agents and could also be useful for the manipulation of cell fate. To investigate the potential of NSAs for the induction of neuronal differentiation, we developed a novel phenotypic ass
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83049b885015d1e4ca672ad4e014656d
https://doi.org/10.1111/cbdd.12488
https://doi.org/10.1111/cbdd.12488
Autor:
Jürgen Schmitt, Anisa Farhat, Gabriel A. Bonaterra, Doris Röthlein, Ralf Kinscherf, Martin Wolf, Helmut Rosemeyer, Edith Malecki
Publikováno v:
Chemistry & Biodiversity. 11:469-482
The insufficient penetration through the cell membranes is one of the major drawbacks of chemotherapeutics such as 5-fluorouracil (5-FU; 1). To improve the penetration, a useful strategy is the attachment of lipophilic moieties. Thus, we have synthes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5c485ac0f026a4942f05f7943f35dae
https://doi.org/10.1002/cbdv.201300347
https://doi.org/10.1002/cbdv.201300347
Autor:
Edith Malecki, Ralf Kinscherf, Martin Wolf, Anisa Farhat, Helmut Rosemeyer, Gabriel A. Bonaterra, Doris Röthlein, Jürgen Schmitt
Publikováno v:
Chemistry & Biodiversity. 10:2235-2246
One of the major drawbacks of chemotherapeutics is their insufficient penetration through cell membranes due to a high hydrophobicity. Thus, we have synthesized a series of selected nucleolipid derivatives of 5-fluorouridine (5-FUrd; 2a), carrying li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a314029a71d039b65125ab23bf0d8cb
https://doi.org/10.1002/cbdv.201300219
https://doi.org/10.1002/cbdv.201300219
Publikováno v:
Chemistry & Biodiversity. 10:2209-2220
The cancerostatic 5-fluorouridine (5-FUrd; 1) was sequentially sugar-protected by introduction of a 2',3'-O-heptylidene ketal group (→2), followed by 5'-O-monomethoxytritylation (→3). This fully protected derivative was submitted to Mitsunobu rea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7ead58194928a26d88b442912e28e2b
https://doi.org/10.1002/cbdv.201300107
https://doi.org/10.1002/cbdv.201300107
Publikováno v:
Helvetica Chimica Acta. 96:872-888
Three pyrimidine nucleosides, uridine (1), 5-methyluridine (6), and 2′-deoxythymidine (11), were converted to amphiphilic nucleolipids. Compounds 1 and 6 were lipophilized by introduction of symmetric ketal moieties with various carbon chain length
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::41f41745903d8da73d1c681ca0d732d2
https://doi.org/10.1002/hlca.201200573
https://doi.org/10.1002/hlca.201200573
Publikováno v:
Chemistry & Biodiversity. 10:39-61
2'-Deoxyinosine (1) and thymidine (7) were N-alkylated with geranyl and farnesyl moieties. These hydrophobic derivatives, 3a and 3b, and 9a and 9b, respectively, represent the first synthetic biomimetic nucleoterpenes and were subsequently 5'-protect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3e164fcfaa4671ad0997af30f0067ab
https://doi.org/10.1002/cbdv.201100338
https://doi.org/10.1002/cbdv.201100338
Autor:
Edith Malecki, Helmut Rosemeyer
Publikováno v:
Helvetica Chimica Acta. 93:1500-1512
The synthesis of a series of cyclic and acyclic O-2’,3’-ketal derivatives of the cancerostatic 5fluorouridine (2a) is described. The novel compounds were characterized by 1H- and 13C-NMR, and UV spectroscopy, as well as by elemental analyses. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c36353472743e402c8447253f9811c2d
https://doi.org/10.1002/hlca.201000121
https://doi.org/10.1002/hlca.201000121
Publikováno v:
Helvetica Chimica Acta. 92:1923-1932
The synthesis of two O-2′,3′-cyclic ketals, i.e., 5 and 6, of the cytostatic 5-fluorouridine (2), carrying a cyclopentane and/or a cyclohexane ring, respectively, is described. The novel compounds were characterized by 1H-, 19F-, and 13C-NMR, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::074987ce3cad8ec26237b8ab3b7b59c9
https://doi.org/10.1002/hlca.200900115
https://doi.org/10.1002/hlca.200900115
Autor:
Helmut Rosemeyer, Emma Werz, Malayko Montilla Martinez, Edith Malecki, Christine Knies, Vanessa Ottenhaus
Publikováno v:
Chemistrybiodiversity. 11(2)
5-Fluorouridine (1a) was converted to its N(3)-farnesylated nucleoterpene derivative 8 by direct alkylation with farnesyl bromide (4). Reaction of the cancerostatic 1a with either acetone, heptan-4-one, nonadecan-10-one, or hentriacontan-16-one affor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4d18e7a8fa0cf923f8cca2b72020a81
https://pubmed.ncbi.nlm.nih.gov/24591313
https://pubmed.ncbi.nlm.nih.gov/24591313
Publikováno v:
Chemistrybiodiversity. 10(10)
The 2',3'-O-levulinic acid derivative 2b of the cancerostatic 5-fluorouridine as well as its N(3)-farnesylated nucleolipid 2d were synthesized and coupled to H2 O-soluble chitosanes of different molecular weight and at various pH values (3.5-5.5) lea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f470da9cbe36850e9e9398f85644e4b
https://pubmed.ncbi.nlm.nih.gov/24130026
https://pubmed.ncbi.nlm.nih.gov/24130026