Zobrazeno 1 - 10
of 152
pro vyhledávání: '"Edith M Lord"'
Autor:
Jian Ye, Brian A Belt, David C Linehan, Tara G Vrooman, Carl J Johnston, Edith M Lord, Scott A Gerber, Nicholas W Gavras, David C Keeley, Angela L Hughson, Gary Hannon, Maggie L Lesch, Jim Eyles
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 5 (2023)
Background Stereotactic body radiotherapy (SBRT) induces immunogenic cell death, leading to subsequent antitumor immune response that is in part counterbalanced by activation of immune evasive processes, for example, upregulation of programmed cell d
Externí odkaz:
https://doaj.org/article/df0812d98765426e92ae92d48cf997b7
Autor:
Jian Ye, Brian A Belt, Booyeon J Han, David C Linehan, Shuyang S Qin, Bradley N Mills, Jesse Garrett-Larsen, Joseph D Murphy, Taylor P Uccello, Tara G Vrooman, Carl J Johnston, Edith M Lord, Scott A Gerber
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 7 (2022)
Background Stereotactic body radiotherapy (SBRT) has been increasingly used as adjuvant therapy in pancreatic ductal adenocarcinoma (PDAC), and induces immunogenic cell death, which leads to the release of tumor antigen and damage-associated molecula
Externí odkaz:
https://doaj.org/article/54b3ed967a784f7b9badf62aea058989
Autor:
Taylor P. Uccello, MS, Sarah A. Kintzel, BS, Bradley N. Mills, PhD, Joseph D. Murphy, MS, Jesse Garrett-Larsen, BS, Nicholas G. Battaglia, PhD, Carlos J. Rodriguez, BS, Michael G. Drage, MD, Jian Ye, PhD, Tanzy M.T. Love, PhD, Carl J. Johnston, PhD, Elizabeth A. Repasky, PhD, Haoming Qiu, MD, David C. Linehan, MD, Edith M. Lord, PhD, Scott A. Gerber, PhD
Publikováno v:
Advances in Radiation Oncology, Vol 7, Iss 2, Pp 100867- (2022)
Purpose: Orthotopic tumors more closely recapitulate human cancers than do ectopic models; however, precision targeting of such internal tumors for radiation therapy (RT) without inducing systemic toxicity remains a barrier. We developed an innovativ
Externí odkaz:
https://doaj.org/article/e6a54b79ca5a4a35a5fb31b880e6b168
Autor:
Taylor P. Uccello, Maggie L. Lesch, Nicholas A. Ullman, Sarah A. Kintzel, Lauren B. Gradzewicz, Trishna Velagaleti, Fergal J. Fleming, Bradley N. Mills, Joseph D. Murphy, Jesse Garrett-Larsen, Haoming Qiu, Michael G. Drage, Jian Ye, Nicholas W. Gavras, Carl J. Johnston, Tanzy M.T. Love, Elizabeth A. Repasky, David C. Linehan, Edith M. Lord, Scott A. Gerber
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 115:733-745
Many solid tumors present with perineural invasion (PNI), and innervation correlates with worsened prognosis. The effects that commonly administered therapies such as radiation therapy (RT) have on PNI status remain unknown. We investigated the contr
Autor:
Carlos J. Ortiz-Bonilla, Taylor P. Uccello, Scott A. Gerber, Edith M. Lord, Edward M. Messing, Yi-Fen Lee
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 6, p 2904 (2022)
Tumor-derived extracellular vesicles (TEVs) play crucial roles in mediating immune responses, as they carry and present functional MHC-peptide complexes that enable them to modulate antigen-specific CD8+ T-cell responses. However, the therapeutic pot
Externí odkaz:
https://doaj.org/article/b08fa3eb1664494091b0b4a58e921866
Autor:
Bradley N. Mills, Kelli A. Connolly, Jian Ye, Joseph D. Murphy, Taylor P. Uccello, Booyeon J. Han, Tony Zhao, Michael G. Drage, Aditi Murthy, Haoming Qiu, Ankit Patel, Nathania M. Figueroa, Carl J. Johnston, Peter A. Prieto, Nejat K. Egilmez, Brian A. Belt, Edith M. Lord, David C. Linehan, Scott A. Gerber
Publikováno v:
Cell Reports, Vol 29, Iss 2, Pp 406-421.e5 (2019)
Summary: Over 80% of pancreatic ductal adenocarcinoma (PDA) patients are diagnosed with non-resectable late-stage disease that lacks effective neoadjuvant therapies. Stereotactic body radiation therapy (SBRT) has shown promise as an emerging neoadjuv
Externí odkaz:
https://doaj.org/article/4e46e83b18694648a2d984f0afc1f88a
Autor:
Scott A. Gerber, David C. Linehan, Brian A. Belt, Edith M. Lord, Carl J. Johnston, Ankit P. Patel, Joseph D. Murphy, Booyeon J. Han, Tony Zhao, Bradley N. Mills, Jian Ye
Pancreatic ductal adenocarcinoma (PDAC) continues to have a dismal prognosis, in part, due to ineffective treatment strategies. The efficacy of some chemotherapies and especially radiotherapy is mediated partially by the immune system. Therefore, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::834304e1f79187791daf99469dd0ac1c
https://doi.org/10.1158/2326-6066.c.6549813
https://doi.org/10.1158/2326-6066.c.6549813
Autor:
Scott A. Gerber, David C. Linehan, Brian A. Belt, Edith M. Lord, Carl J. Johnston, Ankit P. Patel, Joseph D. Murphy, Booyeon J. Han, Tony Zhao, Bradley N. Mills, Jian Ye
Supplemental figure 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34382ac24ed716797c2e66ecc81fb538
https://doi.org/10.1158/2326-6066.22542153.v1
https://doi.org/10.1158/2326-6066.22542153.v1
Autor:
Scott A. Gerber, David C. Linehan, Brian A. Belt, Edith M. Lord, Carl J. Johnston, Ankit P. Patel, Joseph D. Murphy, Booyeon J. Han, Tony Zhao, Bradley N. Mills, Jian Ye
Supplemental figure legends and supplemental tables
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99f5cc41072cf1af7923dea1669c66e8
https://doi.org/10.1158/2326-6066.22542138
https://doi.org/10.1158/2326-6066.22542138
Autor:
Scott A. Gerber, David C. Linehan, Alan W. Katz, Edith M. Lord, Brian A. Belt, Joseph D. Murphy, Taylor P. Uccello, Jian Ye, Jesse Garrett-Larsen, Jocelyn S. Mathew, Chunmo Chen, Michael G. Drage, Haoming Qiu, Bradley N. Mills
Supplementary Data from Modulation of the Human Pancreatic Ductal Adenocarcinoma Immune Microenvironment by Stereotactic Body Radiotherapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2de617731817f8d930fc5307d93a863f
https://doi.org/10.1158/1078-0432.22483464.v1
https://doi.org/10.1158/1078-0432.22483464.v1