Zobrazeno 1 - 10
of 264
pro vyhledávání: '"Edith Heard"'
Autor:
Jasper Panten, Stefania Del Prete, James P. Cleland, Lauren M. Saunders, Job van Riet, Anja Schneider, Paul Ginno, Nina Schneider, Marie-Luise Koch, Xuqi Chen, Moritz Gerstung, Oliver Stegle, Arthur P. Arnold, James M. A. Turner, Edith Heard, Duncan T. Odom
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-8 (2024)
Abstract The Four Core Genotypes (FCG) is a mouse model system used to disentangle the function of sex chromosomes and hormones. We report that a copy of a 3.2 MB region of the X chromosome has translocated to the Y Sry- chromosome and thus increased
Externí odkaz:
https://doaj.org/article/aac4a1679e0d4f16ba7dcb7ac9ca1865
Autor:
Ulrik Ringborg, Joachim vonBraun, Julio Celis, Michael Baumann, Anton Berns, Alexander Eggermont, Edith Heard, Manuel Heitor, Mammen Chandy, Chien‐Jen Chen, Alberto Costa, Francesco De Lorenzo, Edward M. De Robertis, Frederick Charles Dubee, Ingemar Ernberg, Mariya Gabriel, Åslaug Helland, Rui Henrique, Bengt Jönsson, Olli Kallioniemi, Jan Korbel, Mechthild Krause, Douglas R. Lowy, Olivier Michielin, Peter Nagy, Simon Oberst, Vincenzo Paglia, M. Iqbal Parker, Kevin Ryan, Charles L. Sawyers, Joachim Schüz, Katherine Silkaitis, Eric Solary, David Thomas, Peter Turkson, Elisabete Weiderpass, Huanming Yang
Publikováno v:
Molecular Oncology, Vol 18, Iss 2, Pp 245-279 (2024)
Analyses of inequalities related to prevention and cancer therapeutics/care show disparities between countries with different economic standing, and within countries with high Gross Domestic Product. The development of basic technological and biologi
Externí odkaz:
https://doaj.org/article/aed58f51906b40f3875630c0b7d33c89
Autor:
David Gentien, Elnaz Saberi-Ansari, Nicolas Servant, Ariane Jolly, Pierre de la Grange, Fariba Némati, Géraldine Liot, Simon Saule, Aurélie Teissandier, Deborah Bourc’his, Elodie Girard, Jennifer Wong, Julien Masliah-Planchon, Erkan Narmanli, Yuanlong Liu, Emma Torun, Rebecca Goulancourt, Manuel Rodrigues, Laure Villoing Gaudé, Cécile Reyes, Matéo Bazire, Thomas Chenegros, Emilie Henry, Audrey Rapinat, Mylene Bohec, Sylvain Baulande, Radhia M’kacher, Eric Jeandidier, André Nicolas, Giovanni Ciriello, Raphael Margueron, Didier Decaudin, Nathalie Cassoux, Sophie Piperno-Neumann, Marc-Henri Stern, Johan Harmen Gibcus, Job Dekker, Edith Heard, Sergio Roman-Roman, Joshua J. Waterfall
Publikováno v:
Cell Reports, Vol 42, Iss 9, Pp 113132- (2023)
Summary: Uveal melanoma (UM) is a rare cancer resulting from the transformation of melanocytes in the uveal tract. Integrative analysis has identified four molecular and clinical subsets of UM. To improve our molecular understanding of UM, we perform
Externí odkaz:
https://doaj.org/article/1572404d6b2643f898a51a4a704e001b
Autor:
Teresa Robert-Finestra, Beatrice F. Tan, Hegias Mira-Bontenbal, Erika Timmers, Cristina Gontan, Sarra Merzouk, Benedetto Daniele Giaimo, François Dossin, Wilfred F. J. van IJcken, John W. M. Martens, Tilman Borggrefe, Edith Heard, Joost Gribnau
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
SPEN is a key player in initiation of X chromosome inactivation. Here, the authors show that SPEN is required for Xist-mediated silencing of its own antisense regulator Tsix.
Externí odkaz:
https://doaj.org/article/f9c3bed8f0db4091b5ce5fa62f64d44c
Autor:
Lucile Marion-Poll, Benjamin Forêt, Dina Zielinski, Florian Massip, Mikael Attia, Ava C. Carter, Laurène Syx, Howard Y. Chang, Anne-Valerie Gendrel, Edith Heard
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Some autosomal genes are expressed in a random monoallelic manner, but its extent and mechanisms have remained unclear. Here the authors show robust monoallelic expression in cell lines and mice, where the silent allele can be reexpressed using epidr
Externí odkaz:
https://doaj.org/article/b793b4a1019a4a6fa1acd10a7e4751c8
Autor:
Marta Rodríguez-Martínez, Jens Nielsen, Sam Dupont, Jessica Vamathevan, Beverley J Glover, Lindsey C Crosswell, Brendan Rouse, Ben F Luisi, Chris Bowler, Susan M Gasser, Detlev Arendt, Tobias J Erb, Victor de Lorenzo, Edith Heard, Kiran Raosaheb Patil
Publikováno v:
PLoS Biology, Vol 20, Iss 4, p e3001623 (2022)
Molecular biology holds a vast potential for tackling climate change and biodiversity loss. Yet, it is largely absent from the current strategies. We call for a community-wide action to bring molecular biology to the forefront of climate change solut
Externí odkaz:
https://doaj.org/article/0b8e5d7d368e410b8ab8d90ed9606b57
Autor:
Antoine Graindorge, Inês Pinheiro, Anna Nawrocka, Allison C. Mallory, Peter Tsvetkov, Noa Gil, Carlo Carolis, Frank Buchholz, Igor Ulitsky, Edith Heard, Mikko Taipale, Alena Shkumatava
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
RNA-interacting proteome can be identified by RNA affinity purification followed by mass spectrometry. Here the authors developed a different RNA-centric technology that combines high-throughput immunoprecipitation of RNA binding proteins and lucifer
Externí odkaz:
https://doaj.org/article/5e396512bb33457992f7bc69d0a77e2f
Autor:
Michal R. Gdula, Tatyana B. Nesterova, Greta Pintacuda, Jonathan Godwin, Ye Zhan, Hakan Ozadam, Michael McClellan, Daniella Moralli, Felix Krueger, Catherine M. Green, Wolf Reik, Skirmantas Kriaucionis, Edith Heard, Job Dekker, Neil Brockdorff
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
The inactive X chromosome (Xi) has an atypical structure, with global loss of TADs, A/B compartments and formation of mega-domains. Here the authors show that the non-canonical SMC family protein, SmcHD1, important for developmental gene silencing on
Externí odkaz:
https://doaj.org/article/9651dc44fd574c31817692a66b9637db
Publikováno v:
BMC Bioinformatics, Vol 19, Iss 1, Pp 1-16 (2018)
Abstract Background Normalization is essential to ensure accurate analysis and proper interpretation of sequencing data, and chromosome conformation capture data such as Hi-C have particular challenges. Although several methods have been proposed, th
Externí odkaz:
https://doaj.org/article/c448055217c9458bb24953efc44ad4d7
Autor:
Maud Borensztein, Ikuhiro Okamoto, Laurène Syx, Guillaume Guilbaud, Christel Picard, Katia Ancelin, Rafael Galupa, Patricia Diabangouaya, Nicolas Servant, Emmanuel Barillot, Azim Surani, Mitinori Saitou, Chong-Jian Chen, Konstantinos Anastassiadis, Edith Heard
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
X-chromosome inactivation is reversed in the mouse inner cell mass (ICM) through a mechanism that is not fully understood. Here, the authors investigate this process and characterize the contributions of the epigenetic landscape and transcription fac
Externí odkaz:
https://doaj.org/article/cb63d7d22fc842af90dbf976ae402b39