Gene discovery and virus-induced gene silencing reveal branched pathways to major classes of bioactive diterpenoids in

Autor: Tomasz, Czechowski, Edith, Forestier, Sandesh H, Swamidatta, Alison D, Gilday, Amy, Cording, Tony R, Larson, David, Harvey, Yi, Li, Zhesi, He, Andrew J, King, Geoffrey D, Brown, Ian A, Graham

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 119(21)

Most macro- and polycyclic Euphorbiaceae diterpenoids derive from the common C20 precursor casbene. While the biosynthetic pathway from casbene to the lathyrane jolkinol C is characterized, pathways to other more complex classes of bioactive diterpen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::280e21dda278ea3008dc9515a112779f
https://pubmed.ncbi.nlm.nih.gov/35584121

Distinct triterpene synthases in the laticifers of Euphorbia lathyris

Autor: Irini Pateraki, Myriam Preiss, Albert Boronat, Emilio Centeno, Carmen Romero-Segura, Thomas J. Bach, Edith Forestier, Hubert Schaller, Sylvain Darnet, Vincent Compagnon, Anne Berna

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Scientific Reports
Scientific Reports, Nature Publishing Group, 2019, 9, pp.4840. ⟨10.1038/s41598-019-40905-y⟩
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)

Euphorbia lathyris was proposed about fifty years ago as a potential agroenergetic crop. The tremendous amounts of triterpenes present in its latex has driven investigations for transforming this particular biological fluid into an industrial hydroca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56c2c62ad600f129ffa064971791351a
https://doi.org/10.1038/s41598-019-40905-y

A Cytochrome P450-Mediated Intramolecular Carbon-Carbon Ring Closure in the Biosynthesis of Multidrug-Resistance-Reversing Lathyrane Diterpenoids

Autor: Andrew J, King, Geoffrey D, Brown, Alison D, Gilday, Edith, Forestier, Tony R, Larson, Ian A, Graham

Publikováno v: Chembiochem

The Euphorbiaceae produce a wide variety of bioactive diterpenoids. These include the lathyranes, which have received much interest due to their ability to inhibit the ABC transporters responsible for the loss of efficacy of many chemotherapy drugs.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::44924ff3b763a36f2ee7c157f34a31d9
https://pubmed.ncbi.nlm.nih.gov/27272333