Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Edith E. Machowski"'
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
Ongoing SARS-CoV-2 infections are driven by the emergence of various variants, with differential propensities to escape immune containment. Single nucleotide polymorphisms (SNPs) in the RNA genome result in altered protein structures and when these c
Externí odkaz:
https://doaj.org/article/1a9e4ddf975747dd98bc021e1157a675
Autor:
Edith E. Machowski, Matebogo Letutu, Limakatso Lebina, Ziyaad Waja, Reginah Msandiwa, Minja Milovanovic, Bhavna G. Gordhan, Kennedy Otwombe, Sven O. Friedrich, Richard Chaisson, Andreas H. Diacon, Bavesh Kana, Neil Martinson
Publikováno v:
BMC Infectious Diseases, Vol 21, Iss 1, Pp 1-7 (2021)
Abstract Background Pulmonary tuberculosis (TB) in people living with HIV (PLH) frequently presents as sputum smear-negative. However, clinical trials of TB in adults often use smear-positive individuals to ensure measurable bacterial responses follo
Externí odkaz:
https://doaj.org/article/879276020bf045e9ade5f10bfaa38a9d
Autor:
Bhavna G. Gordhan, Julian S. Peters, Amanda McIvor, Edith E. Machowski, Christopher Ealand, Ziyaad Waja, Neil Martinson, Bavesh D. Kana
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Rapid detection of tuberculosis (TB) infection is paramount to curb further transmission. The gold standard for this remains mycobacterial culture, however emerging evidence confirms the presence of differentially culturable tubercle bacteri
Externí odkaz:
https://doaj.org/article/19ef0633fedb477db1d68450d3568b1c
Publikováno v:
IUBMB Life. 70:855-868
Disruption of peptidoglycan (PG) biosynthesis in the bacterial cell wall by β-lactam antibiotics has transformed therapeutic options for bacterial infections. These antibiotics target the transpeptidase domains in penicillin binding proteins (PBPs),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a9e22fe30c06d05cf22f1690776c7764
https://doi.org/10.1002/iub.1761
https://doi.org/10.1002/iub.1761
Autor:
Bintou Ahmadou Ahidjo, Diane Kuhnert, Joanna L McKenzie, Edith E Machowski, Bhavna G Gordhan, Vickery Arcus, Garth L Abrahams, Valerie Mizrahi
Publikováno v:
PLoS ONE, Vol 6, Iss 6, p e21738 (2011)
The chromosome of Mycobacterium tuberculosis (Mtb) encodes forty seven toxin-antitoxin modules belonging to the VapBC family. The role of these modules in the physiology of Mtb and the function(s) served by their expansion are unknown. We investigate
Externí odkaz:
https://doaj.org/article/095ee8d0035e4af4a73a7f473e4d4db6
Autor:
Edith E. Machowski, Bavesh D. Kana
Publikováno v:
Journal of Clinical Microbiology. 55:3384-3394
Molecular diagnostics have revolutionized the management of health care through enhanced detection of disease or infection and effective enrollment into treatment. In recognition of this, the World Health Organization approved the rollout of nucleic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8408cbf4030a340b3826bc737e1fe73c
https://doi.org/10.1128/jcm.01111-17
https://doi.org/10.1128/jcm.01111-17
Autor:
Melissa Chengalroyen, Lusanda Mapela, James Chang, Lethabo Mashigo, Bavesh D. Kana, Sung Joon Kim, Christopher Ealand, Edith E. Machowski, Germar Beukes, Binayak Rimal
Publikováno v:
Applied and Environmental Microbiology. 84
Volume 84, no. 17, e00687-18, 2018, [https://doi.org/10.1128/AEM.00687-18][1]. Page 5: In [Fig. 2B][2], the panel labeled “ABEE2::AB” (among the “Complemented” panels) should appear as shown below. ![Figure][3] [1]: /lookup/doi/10.1128/AEM.00
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9599be2e1eab03ea009be46da54a7dfd
https://doi.org/10.1128/aem.02179-18
https://doi.org/10.1128/aem.02179-18
Autor:
Bavesh D. Kana, Christopher Ealand, James Chang, Sung Joon Kim, Lethabo Mashigo, Edith E. Machowski, Melissa Chengalroyen, Lusanda Mapela, Binayak Rimal, Germar Beukes
Publikováno v:
Applied and environmental microbiology. 84(17)
Resuscitation-promoting factors (Rpfs) have previously been shown to act as growth-stimulatory molecules via their lysozyme-like activity on peptidoglycan in the bacterial cell wall. In this study, we investigated the ability of Mycobacterium smegmat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47225f54212acf18362c30b80762bce0
https://pubmed.ncbi.nlm.nih.gov/30377199
https://pubmed.ncbi.nlm.nih.gov/30377199
Publikováno v:
IUBMB life. 70(9)
Disruption of peptidoglycan (PG) biosynthesis in the bacterial cell wall by β-lactam antibiotics has transformed therapeutic options for bacterial infections. These antibiotics target the transpeptidase domains in penicillin binding proteins (PBPs),
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::525999fabfcf7496c129667a8eff1a1a
https://pubmed.ncbi.nlm.nih.gov/29717815
https://pubmed.ncbi.nlm.nih.gov/29717815
Autor:
Digby F. Warner, Nackmoon Sung, Liana Tsenova, Neil G. Stoker, James C. Sacchettini, Valerie Mizrahi, Gilla Kaplan, Bavesh D. Kana, Bhavna G. Gordhan, Edith E. Machowski, Garth L. Abrahams
Publikováno v:
Journal of Bacteriology. 192:2220-2227
The environment encountered by Mycobacterium tuberculosis during infection is genotoxic. Most bacteria tolerate DNA damage by engaging specialized DNA polymerases that catalyze translesion synthesis (TLS) across sites of damage. M. tuberculosis posse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::113996d57332c95f3209b6ae86d62818
https://doi.org/10.1128/jb.01135-09
https://doi.org/10.1128/jb.01135-09