Dexamethasone enhances glutamine synthetase activity and reduces N-methyl-D-aspartate neurotoxicity in mixed cultures of neurons and astrocytes

Autor: Edith Debroas, Carine Ali, Dominique Duval

Publikováno v: AIMS Molecular Science, Vol 2, Iss 2, Pp 175-189 (2015)

Astrocytes are claimed to protect neurons against excitotoxicity by clearing glutamate from the extracellular space and rapidly converting it into glutamine. Glutamine, is then released into the extracellular medium, taken up by neurons and transform

Externí odkaz: https://doaj.org/article/0e90bb585a754292b335c7d2898a16fe

Estrogen receptor alpha mediates neuronal differentiation and neuroprotection in PC12 cells: critical role of the A/B domain of the receptor

Autor: Yohann Mérot, Edith Debroas, François Ferrière, Gilles Flouriot, Christian Saligaut, Dominique Duval

Publikováno v: Journal of Molecular Endocrinology
Journal of Molecular Endocrinology, BioScientifica, 2005, 35 (2), pp.257-67. ⟨10.1677/jme.1.01826⟩
Journal of Molecular Endocrinology, BioScientifica, 2005, 35, pp.257-267
Journal of Molecular Endocrinology, 2005, 35 (2), pp.257-67. ⟨10.1677/jme.1.01826⟩

Numerous studies, both in vivo and in vitro, have reported neuronal differentiating and neuroprotective actions of estrogens. Most of these estrogenic effects are mediated through specific receptors termed estrogen receptors. The aim of this study wa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87249f51d1e8ef6324c80c0aae1a67ab
https://doi.org/10.1677/jme.1.01826