Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Edith C. Glazer"'
Publikováno v:
Biomolecules, Vol 14, Iss 4, p 441 (2024)
While cytochrome P450 (CYP; P450) enzymes are commonly associated with the metabolism of organic xenobiotics and drugs or the biosynthesis of organic signaling molecules, they are also impacted by a variety of inorganic species. Metallic nanoparticle
Externí odkaz:
https://doaj.org/article/99b43ae924fb416c8e772d6c78c0ba54
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
The cytochrome P450 enzyme CYP1B1 is overexpressed in a variety of tumors, and is correlated with poor treatment outcomes; thus, it is desirable to develop CYP1B1 inhibitors to restore chemotherapy efficacy. Here the authors describe the creation of
Externí odkaz:
https://doaj.org/article/cd3c1b4728124a4f8e73b7f958ed2e00
Publikováno v:
ACS Omega, Vol 5, Iss 30, Pp 18894-18906 (2020)
Externí odkaz:
https://doaj.org/article/ccf0ba56740943c99b14baaf8f4ffd67
Autor:
Richard J. Mitchell, Sarah M. Kriger, Alexander D. Fenton, Dmytro Havrylyuk, Ankit Pandeya, Yang Sun, Tami Smith, Jason E. DeRouchey, Jason M. Unrine, Viral Oza, Jessica S. Blackburn, Yinan Wei, David K. Heidary, Edith C. Glazer
Publikováno v:
RSC Chemical Biology. 4:344-353
Phenanthriplatin forms DNA mono-adducts and induces ribosome biogenesis stress. Using a semi-rational strategy, Ru(ii) complexes were created that act as biological mimics of phenanthriplatin with improved properties.
Publikováno v:
Journal of Medicinal Chemistry. 66:398-412
Autor:
Dmytro Havrylyuk, David K. Heidary, Kimberly C. Stevens, Sean Parkin, L. Henry Moore, Raphael T. Ryan, John P. Selegue, Jessica S. Blackburn, Edith C. Glazer
Publikováno v:
Eur J Inorg Chem
The β-diketone scaffold is a commonly used synthetic intermediate, and is a functional group found in natural products such as curcuminoids. This core structure can also act as a chelating ligand for a variety of metals. In order to assess the poten
Publikováno v:
ChemMedChem
Inhibition of estrogen synthesis is an integral component of the frontline pharmacologic therapy for the treatment of estrogen receptor positive cancers. However, there is currently no direct, high-throughput-ready assay for aromatase (also known as
Autor:
Raphael T. Ryan, Austin C. Hachey, Kimberly Stevens, Sean R. Parkin, Richard J. Mitchell, John P. Selegue, David K. Heidary, Edith C. Glazer
Publikováno v:
Journal of inorganic biochemistry. 238
Photoreactive Ru(II) complexes capable of ejecting ligands have been used extensively for photocaging applications and for the creation of "photocisplatin" reagents. The incorporation of distortion into the structure of the coordination complex lower
Publikováno v:
Curr Opin Chem Biol
Polypyridyl coordinating ligands are common in metal complexes used in medicinal inorganic chemistry. These ligands possess intrinsic cytotoxicity, but detailed data on this phenomenon is sparse, and cytotoxicity values vary widely and are often irre
Autor:
Edith C. Glazer, Angela Casini
Publikováno v:
European Journal of Inorganic Chemistry. 2022