Zobrazeno 1 - 10
of 82
pro vyhledávání: '"Edith Borcoman"'
Autor:
Yohann Loriot, Maud Kamal, Laurene Syx, Remy Nicolle, Celia Dupain, Naoual Menssouri, Igor Duquesne, Pernelle Lavaud, Claudio Nicotra, Maud Ngocamus, Ludovic Lacroix, Lambros Tselikas, Gilles Crehange, Luc Friboulet, Zahra Castel-Ajgal, Yann Neuzillet, Edith Borcoman, Philippe Beuzeboc, Grégoire Marret, Tom Gutman, Jennifer Wong, Francois Radvanyi, Sylvain Dureau, Jean-Yves Scoazec, Nicolas Servant, Yves Allory, Benjamin Besse, Fabrice Andre, Christophe Le tourneau, Christophe Massard, Ivan Bieche
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Metastatic urothelial carcinoma (mUC) is a lethal cancer, with limited therapeutic options. Large-scale studies in early settings provided critical insights into the genomic and transcriptomic characteristics of non-metastatic UC. The genomi
Externí odkaz:
https://doaj.org/article/e0e414a0867f424a9bfcb03a773faebb
Autor:
Elisa Bonnin, Maria Rodrigo Riestra, Federico Marziali, Rafael Mena Osuna, Jordan Denizeau, Mathieu Maurin, Juan Jose Saez, Mabel Jouve, Pierre-Emmanuel Bonté, Wilfrid Richer, Fabien Nevo, Sebastien Lemoine, Nicolas Girard, Marine Lefevre, Edith Borcoman, Anne Vincent-Salomon, Sylvain Baulande, Helene D. Moreau, Christine Sedlik, Claire Hivroz, Ana-Maria Lennon-Duménil, Jimena Tosello Boari, Eliane Piaggio
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Regulatory T cells (Tregs) are plastic cells playing a pivotal role in the maintenance of immune homeostasis. Tregs actively adapt to the microenvironment where they reside; as a consequence, their molecular and functional profiles differ am
Externí odkaz:
https://doaj.org/article/7c63a70c3d6a473080accb289f96f5ea
Autor:
Célia Dupain, Tom Gutman, Elodie Girard, Choumouss Kamoun, Grégoire Marret, Zahra Castel-Ajgal, Marie-Paule Sablin, Cindy Neuzillet, Edith Borcoman, Ségolène Hescot, Céline Callens, Olfa Trabelsi-Grati, Samia Melaabi, Roseline Vibert, Samantha Antonio, Coralie Franck, Michèle Galut, Isabelle Guillou, Maral Halladjian, Yves Allory, Joanna Cyrta, Julien Romejon, Eleonore Frouin, Dominique Stoppa-Lyonnet, Jennifer Wong, Christophe Le Tourneau, Ivan Bièche, Nicolas Servant, Maud Kamal, Julien Masliah-Planchon
Publikováno v:
BMC Biology, Vol 22, Iss 1, Pp 1-12 (2024)
Abstract Background High tumor mutational burden (TMB) was reported to predict the efficacy of immune checkpoint inhibitors (ICIs). Pembrolizumab, an anti-PD-1, received FDA-approval for the treatment of unresectable/metastatic tumors with high TMB a
Externí odkaz:
https://doaj.org/article/38a817e5035043189c5b339051b10be7
Autor:
Grégoire Marret, Stéphane Temam, Maud Kamal, Caroline Even, Jean-Pierre Delord, Caroline Hoffmann, Gilles Dolivet, Olivier Malard, Jérôme Fayette, Olivier Capitain, Sébastien Vergez, Lionel Geoffrois, Frédéric Rolland, Philippe Zrounba, Laurent Laccourreye, Esma Saada-Bouzid, Nicolas Aide, Valérie Bénavent, Jerzy Klijianenko, Constance Lamy, Elodie Girard, Sophie Vacher, Julien Masliah-Planchon, Leanne de Koning, Vincent Puard, Edith Borcoman, Marta Jimenez, Ivan Bièche, Jocelyn Gal, Christophe Le Tourneau
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract There is no strong and reliable predictive biomarker in head and neck squamous cell carcinoma (HNSCC) for EGFR inhibitors. We aimed to identify predictive and pharmacodynamic biomarkers of efficacy of afatinib, a pan-HER tyrosine kinase inhi
Externí odkaz:
https://doaj.org/article/71b235740be44697822692560686e4ae
Autor:
Yohann Loriot, Maud Kamal, Laurene Syx, Remy Nicolle, Celia Dupain, Naoual Menssouri, Igor Duquesne, Pernelle Lavaud, Claudio Nicotra, Maud Ngocamus, Ludovic Lacroix, Lambros Tselikas, Gilles Crehange, Luc Friboulet, Zahra Castel-Ajgal, Yann Neuzillet, Edith Borcoman, Philippe Beuzeboc, Grégoire Marret, Tom Gutman, Jennifer Wong, Francois Radvanyi, Sylvain Dureau, Jean-Yves Scoazec, Nicolas Servant, Yves Allory, Benjamin Besse, Fabrice Andre, Christophe Le tourneau, Christophe Massard, Ivan Bieche
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/4b85e6fb05a1470abbbef069b466a715
Autor:
Sabrina N. Bossio, Carolina Abrate, Jimena Tosello Boari, Constanza Rodriguez, Fernando P. Canale, María C. Ramello, Valentina Brunotto, Wilfrid Richer, Dario Rocha, Christine Sedlik, Anne Vincent-Salomon, Edith Borcoman, Andres Del Castillo, Adriana Gruppi, Elmer Fernandez, Eva V. Acosta Rodríguez, Eliane Piaggio, Carolina L. Montes
Publikováno v:
OncoImmunology, Vol 12, Iss 1 (2023)
ABSTRACTConventional CD4+ T (Tconv) lymphocytes play important roles in tumor immunity; however, their contribution to tumor elimination remains poorly understood. Here, we describe a subset of tumor-infiltrating Tconv cells characterized by the expr
Externí odkaz:
https://doaj.org/article/c2c7022bc10c4d4d97766bb302e5a761
Autor:
Juliette Mainguené, Sophie Vacher, Maud Kamal, Abderaouf Hamza, Julien Masliah‐Planchon, Sylvain Baulande, Sabrina Ibadioune, Edith Borcoman, Wulfran Cacheux, Valentin Calugaru, Laura Courtois, Carole Crozes, Marc Deloger, Elodie Girard, Jean‐Pierre Delord, Antoine Dubray‐Vautrin, Linda Larbi Chérif, Celia Dupain, Emmanuelle Jeannot, Jerzy Klijanienko, Sonia Lameiras, Charlotte Lecerf, Anouchka Modesto, Alain Nicolas, Roman Rouzier, Esma Saada‐Bouzid, Pierre Saintigny, Anne Sudaka, Nicolas Servant, Christophe Le Tourneau, Ivan Bièche
Publikováno v:
Molecular Oncology, Vol 16, Iss 16, Pp 3001-3016 (2022)
A prevalence of around 26% of human papillomavirus (HPV) in head and neck squamous cell carcinoma (HNSCC) has been previously reported. HPV induced oncogenesis mainly involving E6 and E7 viral oncoproteins. In some cases, HPV viral DNA has been detec
Externí odkaz:
https://doaj.org/article/d06dd36b1af84cd3acb67648ff2cbc2c
Autor:
Christophe Le Tourneau, Massimo Ghiani, Maria Chiara Cau, Roberta Depenni, Graziana Ronzino, Pierluigi Bonomo, Vincenzo Montesarchio, Luigi Leo, Jeltje Schulten, Satu Salmio, Diethelm Messinger, Andrea Sbrana, Edith Borcoman, Maria Grazia Ghi
Publikováno v:
Cancer Reports, Vol 6, Iss 5, Pp n/a-n/a (2023)
Abstract Background ENCORE, an observational, prospective, open‐label study, investigated real‐world treatment practices and outcomes with cetuximab plus platinum‐based therapy (PBT) in first‐line (1L) recurrent and/or metastatic squamous cel
Externí odkaz:
https://doaj.org/article/2aac3541984b4cb79407e47c1b6ba1ae
Autor:
Carlos Gomez‐Roca, Caroline Even, Christophe Le Tourneau, Neus Basté, Jean‐Pierre Delord, Jerome Sarini, Sebastien Vergez, Stephane Temam, Caroline Hoffmann, Philippe Rochaix, Edith Borcoman, Bruno Gavillet, Elisabeth Rouits, Annick Ménétrey, Franck Brichory, Daniela Purcea, Gregoire Vuagniaux, Claudio Zanna
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 1, Pp 55-62 (2022)
Abstract Inhibitor of apoptosis proteins (IAPs) regulate apoptosis and modulate NF‐κB signaling thereby driving expression of genes involved in immune/inflammatory responses. The orally available IAP antagonist Debio 1143 has potential to enhance
Externí odkaz:
https://doaj.org/article/763c3b10898c4d3aa67f4e95f05892c4
Innate lymphoid cells: NK and cytotoxic ILC3 subsets infiltrate metastatic breast cancer lymph nodes
Autor:
Louise Rethacker, Maxime Boy, Valeria Bisio, France Roussin, Jordan Denizeau, Anne Vincent-Salomon, Edith Borcoman, Christine Sedlik, Eliane Piaggio, Antoine Toubert, Nicolas Dulphy, Anne Caignard
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
Innate lymphoid cells (ILCs) – which include cytotoxic Natural Killer (NK) cells and helper-type ILC – are important regulators of tissue immune homeostasis, with possible roles in tumor surveillance. We analyzed ILC and their functionality in hu
Externí odkaz:
https://doaj.org/article/996cb421455d4f19a6ba501cc125281c