Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Edite Antunes Ferreira"'
Autor:
Jean-Christophe Bourdon, Kevin Jan Legscha, Edite Antunes Ferreira, Antonios Chamoun, Alexander Lang, Mohamed Hemaid Sayed Awwad, Gigi Nu Hoang Quy Ton, Danuta Galetzka, Borhane Guezguez, Michael Hundemer, Markus Munder, Matthias Theobald, Hakim Echchannaoui
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 6 (2021)
Background Tumor microenvironment-associated T cell senescence is a key limiting factor for durable effective cancer immunotherapy. A few studies have demonstrated the critical role of the tumor suppressor TP53-derived p53 isoforms in cellular senesc
Externí odkaz:
https://doaj.org/article/92aec1eee98146ff8df8385a1b588618
Autor:
Borhane Guezguez, Alexander Lang, Mohamed H.S. Awwad, Jean-Christophe Bourdon, Matthias Theobald, Edite Antunes Ferreira, Hakim Echchannaoui, Markus Munder, Kevin Jan Legscha, Danuta Galetzka, Gigi Nu Hoang Quy Ton, Michael Hundemer, Antonios Chamoun
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 6 (2021)
Journal for Immunotherapy of Cancer
Journal for Immunotherapy of Cancer
BackgroundTumor microenvironment-associated T cell senescence is a key limiting factor for durable effective cancer immunotherapy. A few studies have demonstrated the critical role of the tumor suppressor TP53-derived p53 isoforms in cellular senesce
A Potent Tumor-Reactive p53-Specific Single-Chain TCR without On- or Off-Target Autoimmunity In Vivo
Autor:
Edite Antunes Ferreira, Carina Lotz-Jenne, Jutta Petschenka, Hakim Echchannaoui, Ralf-Holger Voss, Matthias Theobald, Beate Hauptrock
Genetic engineering of T cells with a T cell receptor (TCR) targeting tumor antigen is a promising strategy for cancer immunotherapy. Inefficient expression of the introduced TCR due to TCR mispairing may limit the efficacy and adversely affect the s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c78c8edcfd0b8112197df8fdf0ced2e0
https://europepmc.org/articles/PMC6319330/
https://europepmc.org/articles/PMC6319330/
Autor:
AP Barreiros, Zhanhai Su, Susanne Strand, Dennis Strand, Edite Antunes Ferreira, Peter R. Galle, Jürgen Kuball, Matthias Theobald, Daniela Gottfried
Publikováno v:
The Journal of Immunology. 176:3923-3930
Many human tumors express inducible NO synthetase (NOS2), but the roles of NO in tumor development are not fully elucidated. An important step during tumor development is the acquisition of apoptosis resistance. We investigated the dose-dependent eff
Autor:
Jürgen Kuball, Linda A. Sherman, Matthias Theobald, Renate Engel, Edite Antunes Ferreira, Pedro Romero, Ralf-Holger Voss, Frank Schmitz, Philippe Guillaume, Susanne Strand, Christoph Huber
Publikováno v:
Immunity. 22:117-129
Efficient immune attack of malignant disease requires the concerted action of both CD8 + CTL and CD4 + Th cells. We used human leukocyte antigen (HLA)-A*0201 (A2.1) transgenic mice, in which the mouse CD8 molecule cannot efficiently interact with the
Autor:
Ansgar W. Lohse, Matthias Theobald, Giancarlo Maccagno, Jürgen Burg, Gerd Otto, Peter R. Galle, Stefan Lüth, Edite Antunes Ferreira, M. Schuchmann, Carl C. Schimanski, Markus F. Neurath, Jürgen Kuball, Georg Hess, Andreas Schwarting, Ana Paula Barreiros
Publikováno v:
Transplantation. 78:1774-1779
Background Prolonged persistence of donor-derived T cells after organ transplantation has been proposed to improve long-term allograft survival. However, surviving transplant-derived T cells are also able to mediate devastating graft-versus-host dise
Autor:
Ingo Drexler, Carina Lotz, Matthias Theobald, Sarah Abdel Mutallib, Christoph Huber, Edite Antunes Ferreira, Gerd Sutter
Publikováno v:
International Journal of Cancer. 108:571-579
The human tyrosinase (hTyr) (369-377) cytotoxic T lymphocyte (CTL) epitope is presented by malignant melanoma and various nontransformed cells in association with human leukocyte antigen (HLA)-A*0201 (A2.1) and used for vaccination-based immunotherap
Autor:
Edite Antunes Ferreira, Nicole Oehlrich, Sandra Schneider, Carina Lotz, Marion Moos, Ulrike Liewer, Matthias Theobald, Hartmut Goldschmidt, Michael Hundemer, Susanne Strand, Sarah Abdel Mutallib, Christoph Huber
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 175(2)
Growing evidence indicates that multiple myeloma (MM) and other malignancies are susceptible to CTL-based immune interventions. We studied whether transcription factors inherently involved in the terminal differentiation of mature B lymphocytes into
Autor:
Ulrike, Kuckelkorn, Edite Antunes, Ferreira, Ilse, Drung, Ulrike, Liewer, Peter-Michael, Kloetzel, Matthias, Theobald
Publikováno v:
European journal of immunology. 32(5)
The human wild-type (wt) p53.264-272 peptide is a universal tumor antigen and recognized by HLA-A*0201 (A2.1)-restricted CTL. Generation of this epitope by constitutive 20S proteasomes is prevented by a p53 R to H hotspot mutation at the C-terminal f
Autor:
Christoph Huber, Ulrike Liewer, Arnold J. Levine, Javier Hernandez, Thomas Ruppert, Peter-M. Kloetzel, Judith A. Biggs, Linda A. Sherman, Edite Antunes Ferreira, Annett Häussler, Matthias Theobald, Ulrich H. Koszinowski, Ulrike Kuckelkorn
Publikováno v:
The Journal of Experimental Medicine
A high proportion of tumors arise due to mutation of the p53 tumor suppressor protein. A p53 hotspot mutation at amino acid position 273 from R to H, flanking a peptide epitope that spans residues 264–272, renders cells resistant to killing by huma