Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Edita Capkauskaite"'
Autor:
Vaida Paketurytė-Latvė, Alexey Smirnov, Elena Manakova, Lina Baranauskiene, Vytautas Petrauskas, Asta Zubrienė, Jurgita Matulienė, Virginija Dudutienė, Edita Čapkauskaitė, Audrius Zakšauskas, Janis Leitans, Saulius Gražulis, Kaspars Tars, Daumantas Matulis
Publikováno v:
IUCrJ, Vol 11, Iss 4, Pp 556-569 (2024)
Carbonic anhydrase (CA) was among the first proteins whose X-ray crystal structure was solved to atomic resolution. CA proteins have essentially the same fold and similar active centers that differ in only several amino acids. Primary sulfonamides ar
Externí odkaz:
https://doaj.org/article/ec3b8fbc0d5b437fa117aba7db414107
Autor:
Jurgita Matulienė, Gediminas Žvinys, Vytautas Petrauskas, Agnė Kvietkauskaitė, Audrius Zakšauskas, Kirill Shubin, Asta Zubrienė, Lina Baranauskienė, Lina Kačenauskaitė, Sergei Kopanchuk, Santa Veiksina, Vaida Paketurytė-Latvė, Joana Smirnovienė, Vaida Juozapaitienė, Aurelija Mickevičiūtė, Vilma Michailovienė, Jelena Jachno, Dovilė Stravinskienė, Aistė Sližienė, Agnė Petrošiūtė, Holger M. Becker, Justina Kazokaitė-Adomaitienė, Ala Yaromina, Edita Čapkauskaitė, Ago Rinken, Virginija Dudutienė, Ludwig J Dubois, Daumantas Matulis
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-25 (2022)
Abstract Numerous human cancers, especially hypoxic solid tumors, express carbonic anhydrase IX (CAIX), a transmembrane protein with its catalytic domain located in the extracellular space. CAIX acidifies the tumor microenvironment, promotes metastas
Externí odkaz:
https://doaj.org/article/37ebb5e55c0a4123a7c8f686b66ab087
Autor:
Kęstutis Rutkauskas, Asta Zubrienė, Ingrida Tumosienė, Kristina Kantminienė, Marytė Kažemėkaitė, Alexey Smirnov, Justina Kazokaitė, Vaida Morkūnaitė, Edita Čapkauskaitė, Elena Manakova, Saulius Gražulis, Zigmuntas J. Beresnevičius, Daumantas Matulis
Publikováno v:
Molecules, Vol 19, Iss 11, Pp 17356-17380 (2014)
A series of N-aryl-β-alanine derivatives and diazobenzenesulfonamides containing aliphatic rings were designed, synthesized, and their binding to carbonic anhydrases (CA) I, II, VI, VII, XII, and XIII was studied by the fluorescent thermal shift ass
Externí odkaz:
https://doaj.org/article/801ba8f6972c46bd9927207905c7355b
Autor:
Miglė Kišonaitė, Asta Zubrienė, Edita Capkauskaitė, Alexey Smirnov, Joana Smirnovienė, Visvaldas Kairys, Vilma Michailovienė, Elena Manakova, Saulius Gražulis, Daumantas Matulis
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e114106 (2014)
The early stage of drug discovery is often based on selecting the highest affinity lead compound. To this end the structural and energetic characterization of the binding reaction is important. The binding energetics can be resolved into enthalpic an
Externí odkaz:
https://doaj.org/article/02bd957a8189462b92173944f1ed285f
Autor:
M. Kisonaite, Vaida Linkuviene, Edita Capkauskaite, Elena Manakova, Daumantas Matulis, Saulius Grazulis, Audrius Zakšauskas, L. Jezepcikas, Alexey Smirnov
Publikováno v:
European Journal of Medicinal Chemistry. 156:61-78
Rational design of compounds that would bind specific pockets of the target proteins is a difficult task in drug design. The 12 isoforms of catalytically active human carbonic anhydrases (CAs) have highly similar active sites that make it difficult t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34a66e7b437aa7941a3d36089b4a83a5
https://doi.org/10.1016/j.ejmech.2018.06.059
https://doi.org/10.1016/j.ejmech.2018.06.059
Autor:
Edita Capkauskaite, Vaida Paketuryte, Audrius Zakšauskas, Alexey Smirnov, Daumantas Matulis, Alberta Jankunaite
Publikováno v:
Biophysical Journal. 118:46a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08717605acac094dbda0f80d0000d0c6
https://doi.org/10.1016/j.bpj.2019.11.431
https://doi.org/10.1016/j.bpj.2019.11.431
Autor:
J. Smirnoviene, S. Baksyte, A. Mickeviciute, Alexey Smirnov, Saulius Grazulis, V. Petrauskas, Audrius Zakšauskas, G. Milinaviciute, V. Morkunaite, David D. Timm, Povilas Norvaisas, Jelena Jachno, Jurgita Matuliene, Asta Zubriene, Lina Baranauskiene, Virginija Dudutiene, V. Pilipuityte, Vilma Petrikaite, Justina Kazokaite, Elena Manakova, A. Kasiliauskaite, J. Revuckiene, Edita Capkauskaite, John E. Ladbury, P. Gibieza, Vytautas Smirnovas, M. Kisonaite, Visvaldas Kairys, E. Ivanauskaite, V. Juozapaitiene, Daumantas Matulis, Egidijus Kazlauskas, Vilma Michailoviene, D. Linge
Publikováno v:
Journal of medicinal chemistry. 57(22)
Human carbonic anhydrase IX (CA IX) is highly expressed in tumor tissues, and its selective inhibition provides a potential target for the treatment of numerous cancers. Development of potent, highly selective inhibitors against this target remains a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::072342404824bd0c63bf9dad1c47b553
https://pubmed.ncbi.nlm.nih.gov/25358084
https://pubmed.ncbi.nlm.nih.gov/25358084
Autor:
Saulius Grazulis, Visvaldas Kairys, Sigitas Tumkevicius, Elena Manakova, Daumantas Matulis, Giedre Tamulaitiene, Asta Zubriene, Lina Baranauskiene, Edita Capkauskaite
Publikováno v:
ChemInform. 43
S-Alkylation of pyrimidine derivatives (I) with ω-bromoacetylbenzenesulfonamides (II) and (IV) affords the title compounds (III) and (V), respectively.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ffb54bb69ecdc0151b3631c11198e367
https://doi.org/10.1002/chin.201239179
https://doi.org/10.1002/chin.201239179