Mitochondria and Their Relationship with Common Genetic Abnormalities in Hematologic Malignancies

Autor: Ibolya Czegle, Austin L. Gray, Minjing Wang, Yan Liu, Jun Wang, Edina A. Wappler-Guzzetta

Publikováno v: Life, Vol 11, Iss 12, p 1351 (2021)

Hematologic malignancies are known to be associated with numerous cytogenetic and molecular genetic changes. In addition to morphology, immunophenotype, cytochemistry and clinical characteristics, these genetic alterations are typically required to d

Externí odkaz: https://doaj.org/article/6bb05bebdfec48c783131b3392e883fc

Case report of a patient with chronic myeloid leukemia, BCR::ABL1 positive presented with isolated thrombocytosis and an uncommon JAK2 alteration detected in peripheral blood

Autor: Austin L. Gray, Edina A. Wappler-Guzzetta, Jun Wang, Huynh Le Cao, Yan Liu

Publikováno v: Journal of Hematopathology. 15:95-99

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bb6172617db923f0862461449c4d5cbf
https://doi.org/10.1007/s12308-022-00496-6

Animal models of major depressive disorder and the implications for drug discovery and development

Autor: Brian H. Harvey, Murilo S. de Abreu, Edina A. Wappler-Guzzetta, Maxim Sysoev, Matthew O. Parker, Brian E. Leonard, Allan V. Kalueff, Eero Vasar, Tamara G. Amstislavskaya, Konstantin A. Demin, Dongmei Wang, Tatyana Strekalova, Maria V. Chernysh, Andrey D. Volgin, Erik T. Alpyshov, Mamiko Koshiba, Li Tian, Anna K. Savva, Cai Song

Publikováno v: Demin, K A, Sysoev, M, Chernysh, M V, Savva, A K, Koshiba, M, Wappler-Guzzetta, E A, Song, C, De Abreu, M S, Leonard, B, Parker, M O, Harvey, B H, Tian, L, Vasar, E, Strekalova, T, Amstislavskaya, T G, Volgin, A D, Alpyshov, E T, Wang, D & Kalueff, A V 2019, ' Animal models of major depressive disorder and the implications for drug discovery and development ', Expert Opinion on Drug Discovery, vol. 14, no. 4, pp. 365-378 . https://doi.org/10.1080/17460441.2019.1575360

Introduction: Depression is a highly debilitating psychiatric disorder that affects the global population and causes severe disabilities and suicide. Depression pathogenesis remains poorly understood, and the disorder is often treatment-resistant and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5cf8758fa9690d6af3dbfe2fad63a01
https://doi.org/10.1080/17460441.2019.1575360

DARK Classics in Chemical Neuroscience: Atropine, Scopolamine, and Other Anticholinergic Deliriant Hallucinogens

Autor: Allan V. Kalueff, Vadim A. Shevyrin, Andrey D. Volgin, Edina A. Wappler-Guzzetta, Sergey L. Khatsko, Tatiana O. Kolesnikova, Konstantin N. Zabegalov, Konstantin A. Demin, Anton M. Lakstygal

Publikováno v: ACS chemical neuroscience. 10(5)

Anticholinergic drugs based on tropane alkaloids, including atropine, scopolamine, and hyoscyamine, have been used for various medicinal and toxic purposes for millennia. These drugs are competitive antagonists of acetylcholine muscarinic (M-) recept

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::628ec55ec7875ab77882d500082af04e
https://pubmed.ncbi.nlm.nih.gov/30566832

Zebrafish models of diabetes-related CNS pathogenesis

Autor: Dongni Yan, Polina A. Alekseeva, Erik T. Alpsyshov, Nazar Serikuly, Anton M. Lakstygal, Mengyao Wang, Dmitry A. Lifanov, Murilo S. de Abreu, Edina A. Wappler-Guzzetta, Dongmei Wang, Allan V. Kalueff, JiaJia Wang, Andrey D. Volgin, Zhichong Tang, Tamara G. Amstislavskaya, Cai Song, Konstantin A. Demin

Publikováno v: Progress in neuro-psychopharmacologybiological psychiatry. 92

Diabetes mellitus (DM) is a common metabolic disorder that affects multiple organ systems. DM also affects brain processes, contributing to various CNS disorders, including depression, anxiety and Alzheimer's disease. Despite active research in human

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::412a291f4e797db910d2476d176001c6
https://pubmed.ncbi.nlm.nih.gov/30476525