Výsledky vyhledávání - "Edilene Siqueira"

Akademický článek

Analysis of the interplay between MeCP2 and histone H1 during in vitro differentiation of human ReNCell neural progenitor cells

Autor: Edilene Siqueira, Bo-Hyun Kim, Larry Reser, Robert Chow, Kerry Delaney, Manel Esteller, Mark M. Ross, Jeffrey Shabanowitz, Donald F. Hunt, Sonia Guil, Juan Ausió

Publikováno v: Epigenetics, Vol 18, Iss 1 (2023)

ABSTRACTAn immortalized neural cell line derived from the human ventral mesencephalon, called ReNCell, and its MeCP2 knock out were used. With it, we characterized the chromatin compositional transitions undergone during differentiation, with special

Externí odkaz: https://doaj.org/article/54a5cb1d65414b17924e9dea1aa45c9f

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Akademický článek

Analysis of the circRNA and T-UCR populations identifies convergent pathways in mouse and human models of Rett syndrome

Autor: Edilene Siqueira, Aida Obiols-Guardia, Olga C. Jorge-Torres, Cristina Oliveira-Mateos, Marta Soler, Deepthi Ramesh-Kumar, Fernando Setién, Daniëlle van Rossum, Ainhoa Pascual-Alonso, Clara Xiol, Cristina Ivan, Masayoshi Shimizu, Judith Armstrong, George A. Calin, R. Jeroen Pasterkamp, Manel Esteller, Sonia Guil

Publikováno v: Molecular Therapy: Nucleic Acids, Vol 27, Iss , Pp 621-644 (2022)

Noncoding RNAs play regulatory roles in physiopathology, but their involvement in neurodevelopmental diseases is poorly understood. Rett syndrome is a severe, progressive neurodevelopmental disorder linked to loss-of-function mutations of the MeCP2 g

Externí odkaz: https://doaj.org/article/a24c0804adeb4f648f12b88418359a68

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Akademický článek

The transcribed ultraconserved region uc.160+ enhances processing and A‐to‐I editing of the miR‐376 cluster: hypermethylation improves glioma prognosis

Autor: Marta Soler, Veronica Davalos, Anaís Sánchez‐Castillo, Carlos Mora‐Martinez, Fernando Setién, Edilene Siqueira, Manuel Castro de Moura, Manel Esteller, Sonia Guil

Publikováno v: Molecular Oncology, Vol 16, Iss 3, Pp 648-664 (2022)

Transcribed ultraconserved regions (T‐UCRs) are noncoding RNAs derived from DNA sequences that are entirely conserved across species. Their expression is altered in many tumor types, and, although a role for T‐UCRs as regulators of gene expressio

Externí odkaz: https://doaj.org/article/ee3cdf516620494bac93ec6af8f9010f

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Akademický článek

Syzygium malaccense fruit supplementation protects mice brain against high-fat diet impairment and improves cognitive functions

Autor: Ângela Giovana Batista, Monique Culturato P. Mendonça, Edilene Siqueira Soares, Juliana Kelly da Silva-Maia, Ana Paula Dionísio, Cesar R. Sartori, Maria Alice da Cruz-Höfling, Mário Roberto Maróstica Júnior

Publikováno v: Journal of Functional Foods, Vol 65, Iss , Pp 103745- (2020)

In this study, we supplemented a high-fat diet (HF) with 5% powder of freeze-dried Syzygium malaccense fruit (HS) and investigated proofs of peripheral insulin resistance, hippocampal AKT–GSK3-β–tau activation, learning/memory performance, and b

Externí odkaz: https://doaj.org/article/3f623f99549243beb9214e5b5be76c3b

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Akademický článek

Jaboticaba berry peel intake increases short chain fatty acids production and prevent hepatic steatosis in mice fed high-fat diet

Autor: Ângela Giovana Batista, Juliana Kelly da Silva-Maia, Monique Culturato P. Mendonça, Edilene Siqueira Soares, Glaucia Carielo Lima, Stanislau Bogusz Junior, Maria Alice da Cruz-Höfling, Mário Roberto Maróstica Júnior

Publikováno v: Journal of Functional Foods, Vol 48, Iss , Pp 266-274 (2018)

In this study, a preventive model was proposed to check whether the intake of Myrciaria jaboticaba berry peel (MJP) could avoid harmful effects caused by a high-fat diet. The intake of the high-fat diet supplemented with MJP (HM mice) down-regulated

Externí odkaz: https://doaj.org/article/76e3b4083f7b48a6b2adb4506e644fde

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