Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Edilberto Bermudez"'
Publikováno v:
Journal of Applied Toxicology. 33:593-606
Methyl tertiary-butyl ether (MTBE) has been used as a gasoline additive to reduce tailpipe emissions and its use has been discontinued. There remains a concern that drinking water sources have been contaminated with MTBE. A two-year drinking water ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2096205a19597820bcb3333bb12485a
https://doi.org/10.1002/jat.1776
https://doi.org/10.1002/jat.1776
Publikováno v:
Journal of Applied Toxicology. 32:687-706
Thirteen-week and one-year toxicity studies of methyl tertiary-butyl ether (MTBE) administered in drinking water to Wistar rats were conducted. Male and female rats were exposed to MTBE in drinking water at 0.5, 3, 7.5 and 15 mg ml(-1) for 13 weeks a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb6edd6dbab9789bf1d52e52342ba96e
https://doi.org/10.1002/jat.1674
https://doi.org/10.1002/jat.1674
Autor:
Harvey J. Clewell, Gabrielle A. Willson, Edilberto Bermudez, Russell S. Thomas, Jerry L. Campbell, Darol E. Dodd, Melvin E. Andersen
Publikováno v:
Toxicological Sciences. 118:716-731
Formaldehyde (FA), an endogenous cellular aldehyde, is a rat nasal carcinogen. In this study, concentration and exposure duration transitions in FA mode of action (MOA) were examined with pharmacokinetic (PK) modeling for tissue formaldehyde acetal (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0a46e8c7ffb73f16cdf9c01cd749ad0
https://doi.org/10.1093/toxsci/kfq303
https://doi.org/10.1093/toxsci/kfq303
Publikováno v:
Toxicological Sciences. 116:441-451
Inhaled formaldehyde is classified as a known human and animal carcinogen, causing nasopharyngeal cancer. Additionally, limited epidemiological evidence for leukemia in humans is available; however, this is inconsistent across studies. Both genotoxic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b09cbace3a253aaaf42db0115d716647
https://doi.org/10.1093/toxsci/kfq061
https://doi.org/10.1093/toxsci/kfq061
Autor:
Harvey J. Clewell, Melvin E. Andersen, Edilberto Bermudez, Gabrielle A. Willson, Russell S. Thomas
Publikováno v:
Toxicological Sciences. 105:368-383
Repeated and acute exposure studies assessed time and concentration-dependencies of nasal responses to formaldehyde. Exposures were to 0, 0.7, 2, and 6 ppm for 6 h/day, 5 days/week for up to 3 weeks. Neither cell proliferation nor histopathology was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::376461c5a2f6dee5e44e0400aee263ae
https://doi.org/10.1093/toxsci/kfn097
https://doi.org/10.1093/toxsci/kfn097
Autor:
E. E. Reverdy, James B. Mangum, Jeffrey I. Everitt, Bahman Asgharian, Brian A. Wong, Edilberto Bermudez
Publikováno v:
Inhalation toxicology. 12
Elevation of protein carbonyls has been implicated in the clinical setting as a result of oxidant damage associated with a number of disease states in both humans and laboratory animals. Protein carbonyls, the product of oxidative modification of ami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c759f48bfa05abfa6923250bd788925b
https://pubmed.ncbi.nlm.nih.gov/26368627
https://pubmed.ncbi.nlm.nih.gov/26368627
Publikováno v:
Toxicological Sciences. 74:165-173
Interspecies differences in pulmonary and pleural responses to the inhalation of natural mineral and synthetic vitreous fibers have been observed in chronic and subchronic studies. However, the reasons for these differences are not clearly understood
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9458e6e711751746ae3fa52698ffcb08
https://doi.org/10.1093/toxsci/kfg092
https://doi.org/10.1093/toxsci/kfg092
Autor:
Edward E. Reverdy, Paul M. Hext, Brian A. Wong, James B. Mangum, David B. Warheit, Bahman Asgharian, Derek B. Janszen, Jeffrey I. Everitt, Edilberto Bermudez
Publikováno v:
Toxicological Sciences. 70:86-97
Female mice, rats, and hamsters were exposed to 10, 50, or 250 mg/m 3 pigmentary titanium dioxide (p-TiO 2 ) particles for 6 h per day and 5 days per week for 13 weeks with recovery groups held for an additional 4, 13, 26, or 52 weeks postexposure (4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bef60d13df2bfd95b443a9a9bb844bbd
https://doi.org/10.1093/toxsci/70.1.86
https://doi.org/10.1093/toxsci/70.1.86
Autor:
Derek B. Janszen, Owen R. Moss, Thomas R. Gelzleichter, James B. Mangum, Jeffrey I. Everitt, Edilberto Bermudez, Brian A. Wong
Publikováno v:
Toxicological Sciences. 49:93-101
The present study was designed to determine whether pleural fiber burdens or subchronic pleural fibroproliferative and inflammatory changes can help explain the marked interspecies differences in pleural fibrosis and mesothelioma that are observed fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa4347be836a15b49136a8a77eac8256
https://doi.org/10.1093/toxsci/49.1.93
https://doi.org/10.1093/toxsci/49.1.93
Autor:
Brian A. Wong, Edilberto Bermudez, Jeffrey I. Everitt, James B. Mangum, Owen R. Moss, Thomas R. Gelzleichter, Derek B. Janszen
Publikováno v:
Environmental Health Perspectives
In the present subchronic study, we compared pleural inflammation, visceral pleural collagen deposition, and visceral and parietal pleural mesothelial cell proliferation in rats and hamsters identically exposed to a kaolin-based refractory ceramic fi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e618d818009b781106eb983ab0aa0eb
https://doi.org/10.1289/ehp.97105s51209
https://doi.org/10.1289/ehp.97105s51209