Zobrazeno 1 - 10
of 154
pro vyhledávání: '"Edgars Liepinsh"'
Autor:
Edgars Liepinsh, Baiba Svalbe, Gundega Stelfa, Solveiga Grinberga, Liga Zvejniece, Helgi B. Schiöth, Maija Dambrova
Publikováno v:
Molecular Autism, Vol 14, Iss 1, Pp 1-5 (2023)
Abstract Deletion of exon 2 of the trimethyllysine hydroxylase epsilon (TMLHE) gene was identified in probands with autism spectrum disorder (ASD). TMLHE encodes the first enzyme in carnitine biosynthesis, N6-trimethyllysine dioxygenase (TMLD). Resea
Externí odkaz:
https://doaj.org/article/888378238f98412c8fc26df3fd5b663f
Autor:
Liga Zvejniece, Baiba Svalbe, Edijs Vavers, Melita Ozola, Solveiga Grinberga, Baiba Gukalova, Eduards Sevostjanovs, Edgars Liepinsh, Maija Dambrova
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 168, Iss , Pp 115803- (2023)
Long-chain acylcarnitines (LCACs) are intermediates of fatty acid oxidation and are known to exert detrimental effects on mitochondria. This study aimed to test whether lowering LCAC levels with the anti-ischemia compound 4-[ethyl(dimethyl)ammonio]bu
Externí odkaz:
https://doaj.org/article/3f0ea55ad0d343ed96f7ef8b1fb33f5f
Autor:
Laura Andze, Sanita Vitolina, Rudolfs Berzins, Janis Rizikovs, Daniela Godina, Arturs Teresko, Solveiga Grinberga, Eduards Sevostjanovs, Helena Cirule, Edgars Liepinsh, Aigars Paze
Publikováno v:
Plants, Vol 13, Iss 1, p 145 (2024)
Birch outer bark extract (BBE), containing pentacyclic triterpenes such as betulin, lupeol, and betulinic acid, is a widely recognized natural product renowned for its diverse pharmacological effects. However, its limited water solubility restricts i
Externí odkaz:
https://doaj.org/article/f4052903aace41e793b0c1165ca05bf9
Publikováno v:
Data in Brief, Vol 46, Iss , Pp 108890- (2023)
This dataset describes in detail the outcomes of acute trimethylamine N-oxide (TMAO) administration on cardiac, vascular and mitochondrial functionality in ex vivo and in vivo models.The accumulation of TMAO in target tissues was assessed after perfo
Externí odkaz:
https://doaj.org/article/81acd6a97f794563a043121de42beebd
Autor:
Ioanna Papatheodorou, Marina Makrecka-Kuka, Janis Kuka, Edgars Liepinsh, Maija Dambrova, Antigone Lazou
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Myocardial ischemia/reperfusion (I/R) injury leads to significant impairment of cardiac function and remains the leading cause of morbidity and mortality worldwide. Activation of peroxisome proliferator-activated receptor β/δ (PPARβ/δ) confers ca
Externí odkaz:
https://doaj.org/article/b53a9960aa3a4fa58ac6b1296b9e28cf
Autor:
Diana Zelencova-Gopejenko, Melita Videja, Aiga Grandane, Linda Pudnika-Okinčica, Anda Sipola, Karlis Vilks, Maija Dambrova, Kristaps Jaudzems, Edgars Liepinsh
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 6, p 5528 (2023)
Heart-type fatty-acid binding protein (FABP3) is an essential cytosolic lipid transport protein found in cardiomyocytes. FABP3 binds fatty acids (FAs) reversibly and with high affinity. Acylcarnitines (ACs) are an esterified form of FAs that play an
Externí odkaz:
https://doaj.org/article/28b74deb62ad4bbf893cfbf819d73a50
Autor:
Katja Becker, Sha Cao, Anna Nilsson, Maria Erlandsson, Sven-Kevin Hotop, Janis Kuka, Jon Hansen, Klara Haldimann, Solveiga Grinberga, Talia Berruga-Fernández, Douglas L. Huseby, Reza Shariatgorji, Evelina Lindmark, Björn Platzack, Erik C. Böttger, David Crich, Lena E. Friberg, Carina Vingsbo Lundberg, Diarmaid Hughes, Mark Brönstrup, Per E. Andrén, Edgars Liepinsh, Sven N. Hobbie
Publikováno v:
EBioMedicine, Vol 73, Iss , Pp 103652- (2021)
Background: The clinical-stage drug candidate EBL-1003 (apramycin) represents a distinct new subclass of aminoglycoside antibiotics for the treatment of drug-resistant infections. It has demonstrated best-in-class coverage of resistant isolates, and
Externí odkaz:
https://doaj.org/article/b25c8a267d4642389bf6d5a2908a5a98
Autor:
Reinis Vilskersts, Karlis Vilks, Melita Videja, Helena Cirule, Olga Zharkova‐Malkova, Eduards Sevostjanovs, Maija Dambrova, Edgars Liepinsh
Publikováno v:
Physiological Reports, Vol 8, Iss 22, Pp n/a-n/a (2020)
Abstract Many drug candidates have shown significant renoprotective effects in preclinical models; however, there is no clinically used effective pharmacotherapy for acute kidney injury. The failure to translate from bench to bedside could be due to
Externí odkaz:
https://doaj.org/article/2b45ca3e61b64f7abc67970127fbf3f1
Autor:
Melita Videja, Eduards Sevostjanovs, Sabine Upmale-Engela, Edgars Liepinsh, Ilze Konrade, Maija Dambrova
Publikováno v:
Nutrients, Vol 14, Iss 5, p 1093 (2022)
Elevated plasma levels of trimethylamine N-oxide (TMAO) have been proposed as a diet-derived biomarker of cardiometabolic disease risk. Caloric restriction is the most common dietary intervention used to improve cardiometabolic health; however, novel
Externí odkaz:
https://doaj.org/article/5f45eede14344ca5bd542556b33b8666
Autor:
Edgars Liepinsh, Elina Makarova, Liga Plakane, Ilze Konrade, Kaspars Liepins, Melita Videja, Eduards Sevostjanovs, Solveiga Grinberga, Marina Makrecka‐Kuka, Maija Dambrova
Publikováno v:
Physiological Reports, Vol 8, Iss 12, Pp n/a-n/a (2020)
Abstract Aim Exercise training induces adaptations in muscle and other tissue mitochondrial metabolism, dynamics, and oxidative phosphorylation capacity. Mitochondrial fatty acid oxidation was shown to be pivotal for the anti‐inflammatory status of
Externí odkaz:
https://doaj.org/article/5847bffbbd334bf2a28ab481018657ab