Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Edgardo Laborde"'
Autor:
Edgardo Laborde, Vara Prasad Manchem
Publikováno v:
Current Medicinal Chemistry. 9:2231-2242
Diabetes mellitus refers to a spectrum of syndromes characterized by abnormally high levels of glucose in blood. These syndromes are associated with an absolute (Type 1 diabetes) or relative (Type 2 diabetes) deficiency of insulin, coupled with varyi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::720215140ffd4118b719f102ae881540
https://doi.org/10.2174/0929867023368665
https://doi.org/10.2174/0929867023368665
Autor:
Songyuan Shi, Schow Steven R, Hugo O. Villar, Deborah K. Toavs, Kozlowski Michael R, Vara Prasad Manchem, Michael M. Wick, Wayne R. Spevak, Ronald A. Kohanski, Lum Robert T, Edgardo Laborde, Ira D. Goldfine, Cristina P. Cristobal
Publikováno v:
Diabetes. 50:824-830
Insulin resistance, an important feature of type 2 diabetes, is manifested as attenuated insulin receptor (IR) signaling in response to insulin binding. A drug that promotes the initiation of IR signaling by enhancing IR autophosphorylation should, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f103fbd5946f762ca4747a7b04943945
https://doi.org/10.2337/diabetes.50.4.824
https://doi.org/10.2337/diabetes.50.4.824
Autor:
Taylor Merry, Selvi Pradeepan, Raji Sundaramoorthi, Virginia A. Jacobsen, Mayumi Uesugi, Vaibhav Varkhedkar, Chi B. Vu, Chester A. Metcalf, Jeremy Green, Dennis A. Holt, Edgardo Laborde, Karina J. Macek, Yinka Green
Publikováno v:
Tetrahedron Letters. 39:3435-3438
An efficient method for the preparation of protected phosphate ester-linked resins in high yield and purity is presented. Variation in tether length/functionality and substitution pattern of the phenol precursors, as well as mild deprotection conditi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa37765070d233783f49b9f5cf51fb75
https://doi.org/10.1016/s0040-4039(98)00586-3
https://doi.org/10.1016/s0040-4039(98)00586-3
Publikováno v:
The Journal of Organic Chemistry. 59:3193-3201
Enantiomerically pure (E)-2-bromo- and (E)-2-iodovinyl sulfoxides 3a and 3b have been prepared in multigram quantities from (E)-1,2-bis(tri-n-butylstannyl)ethene; enantiomerically pure (E)-2-(mesyloxy)vinyl sulfoxide 3c has been synthesized by reacti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2672a3ecd83b48390e923db4087bb747
https://doi.org/10.1021/jo00090a042
https://doi.org/10.1021/jo00090a042
Autor:
Claude C.A. Bernard, Takahito Jomori, Kunihisa Baba, Masayuki Okamoto, Robert W. Macsata, Fanying Meng, Brian T. Peterson, Takashi Nakamura, Yukiharu Matsumoto, Tracy M. Handel, Edgardo Laborde, Reyna J. Simon, Hua Xu, Atsushi Miyachi, Hideaki Inagaki, Louise Robinson, Yoshiro Ishiwata, Steve R. Schow
Publikováno v:
Journal of medicinal chemistry. 54(6)
Through the application of TRAP (target-related affinity profiling), we identified a novel class of heteroaroylphenylureas that inhibit human CCL2-induced chemotaxis of monocytes/macrophages both in vitro and in vivo. This inhibition was concentratio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61d792defc3878f102dde956d2c8ebe0
https://pubmed.ncbi.nlm.nih.gov/21341682
https://pubmed.ncbi.nlm.nih.gov/21341682
Autor:
Edgardo Laborde, Steven VanderRoest, Mel C. Schroeder, John S. Kiely, Mark J. Suto, Themis E. Joannides, John M. Domagala, Martin A. Shapiro, Josephine A. Sesnie, Susan Elizabeth Hagen
Publikováno v:
Journal of Medicinal Chemistry. 36:871-882
A series of stereochemically pure 7-[3-(1-aminoethyl)-1-pyrrolidinyl]-1, 4-dihydro-4-oxoquinoline and 1,8-naphthyridine-3-carboxylic acids, with varied substituents at the 1-, 5-, and 8-positions, were synthesized to study the effects of the 7-[3-(1-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9465083060745813bc27d18171a3041b
https://doi.org/10.1021/jm00059a012
https://doi.org/10.1021/jm00059a012
Publikováno v:
ChemInform. 22
A convergent synthesis of 1,8-naphthyridine antibacterials bearing a carbon-carbon bonded, acyclic or cyclic vinyl substituent at the C-7 position has been achieved. The synthetic methodology is based upon the palladium-catalyzed cross coupling of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b6d06ec13eef590d5b518585a9dabb8
https://doi.org/10.1002/chin.199129189
https://doi.org/10.1002/chin.199129189
Publikováno v:
ChemInform. 22
Cyclic β-tributylstannyl-α,β-unsaturated ketones, alcohols, and amines have been prepared by a highly efficient process. These reagents undergo palladium-catalyzed, intermolecular vinylic cross-coupling with 7-quinolyltriflates and 7-chloro-1,8-na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6162aa351839c7e1afdf54438eb6d7b1
https://doi.org/10.1002/chin.199103193
https://doi.org/10.1002/chin.199103193
Publikováno v:
ChemInform. 23
A series of 1-cyclopropyl-1,4-dihydro-4-oxoquinolines was prepared in which the C-7 position is substituted with a vinyl, a 1-cyclopentenyl, or a 1,2,3,6-tetrahydro-4-pyridinyl group. These quinolones were synthesized via a palladium-catalyzed cross
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6145fe12aef04b8b4107b5552991f906
https://doi.org/10.1002/chin.199215192
https://doi.org/10.1002/chin.199215192
Autor:
Edgardo Laborde
Publikováno v:
ChemInform. 24
Monosubstituted olefins conjugated to an aromatic or heteroaromatic ring undergo 1,3-dipolar cycloaddition with the azomethie ylide derived from N-benzyl-N-(methoxymethyl)trimethylsilylamine to give 3-aryl- and 3-hetero-arylpyrrolidines in good to ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1af73dea58bece6ec188e1da68b8f5c3
https://doi.org/10.1002/chin.199312151
https://doi.org/10.1002/chin.199312151