Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Edgar Trelles-Sticken"'
Autor:
Fiona Chapman, Luuk de Haan, Linda Gijzen, Wouter Strijker, Edgar Trelles Sticken, Sarah Jean Pour, Roman Wieczorek, Florian Haberstroh, Sandra Otte, Thomas Nahde, Liam Simms, Matthew Stevenson
Publikováno v:
Frontiers in Toxicology, Vol 6 (2024)
BackgroundSmoking cigarettes is a cause of serious diseases in smokers, including cardiovascular disease. Through a pathway of endothelial dysfunction, lipid infiltration, macrophage recruitment and vascular remodeling, atherosclerosis is fundamental
Externí odkaz:
https://doaj.org/article/0d419d3534074626a058c1b663677538
Autor:
Marjory Moreau, Liam Simms, Melvin E. Andersen, Edgar Trelles Sticken, Roman Wieczorek, Sarah Jean Pour, Fiona Chapman, Karin Roewer, Sandra Otte, Jeffrey Fisher, Matthew Stevenson
Publikováno v:
Frontiers in Toxicology, Vol 6 (2024)
With the use of in vitro new approach methodologies (NAMs) for the assessment of non-combustible next-generation nicotine delivery products, new extrapolation methods will also be required to interpret and contextualize the physiological relevance of
Externí odkaz:
https://doaj.org/article/06e7c45c8815464bb61eca7e8d431b5c
Autor:
Fiona Chapman, Sarah Jean Pour, Roman Wieczorek, Edgar Trelles Sticken, Jessica Budde, Karin Röwer, Sandra Otte, Elizabeth Mason, Lukasz Czekala, Thomas Nahde, Grant O’Connell, Liam Simms, Matthew Stevenson
Publikováno v:
Frontiers in Toxicology, Vol 5 (2023)
Tobacco harm reduction (THR) involves providing adult smokers with potentially reduced harm modes of nicotine delivery as alternatives to smoking combustible cigarettes. Heated tobacco products (HTPs) form a category with THR potential due to their a
Externí odkaz:
https://doaj.org/article/e61b781ed582475791e5e7e9411f68f8
Autor:
Lukasz Czekala, Roman Wieczorek, Liam Simms, Fan Yu, Jessica Budde, Edgar Trelles Sticken, Kathryn Rudd, Thomas Verron, Oleg Brinster, Matthew Stevenson, Tanvir Walele
Publikováno v:
Current Research in Toxicology, Vol 2, Iss , Pp 99-115 (2021)
Smoking is a cause of serious diseases in smokers including chronic respiratory diseases. This study aimed to evaluate the tobacco harm reduction (THR) potential of an electronic vapor product (EVP, myblu™) compared to a Kentucky Reference Cigarett
Externí odkaz:
https://doaj.org/article/cbd84fb8d9144c06af8e4733ebcfdf02
Autor:
Liam Simms, Elizabeth Mason, Ellen L. Berg, Fan Yu, Kathryn Rudd, Lukasz Czekala, Edgar Trelles Sticken, Oleg Brinster, Roman Wieczorek, Matthew Stevenson, Tanvir Walele
Publikováno v:
Current Research in Toxicology, Vol 2, Iss , Pp 309-321 (2021)
A growing number of public health bodies, regulators and governments around the world consider electronic vapor products a lower risk alternative to conventional cigarettes. Of critical importance are rapid new approach methodologies to enable the sc
Externí odkaz:
https://doaj.org/article/06f36e7c18fa4832aef4f67611546bfb
Autor:
Liam Simms, Kathryn Rudd, Jessica Palmer, Lukasz Czekala, Fan Yu, Fiona Chapman, Edgar Trelles Sticken, Roman Wieczorek, Lisa Maria Bode, Matthew Stevenson, Tanvir Walele
Publikováno v:
Current Research in Toxicology, Vol 1, Iss , Pp 161-173 (2020)
devTOX quickPredict (devTOXqP) is a metabolomics biomarker-based assay that utilises human induced pluripotent stem (iPS) cells to screen for potential early stage embryonic developmental toxicity in vitro. Developmental toxicity potential is assesse
Externí odkaz:
https://doaj.org/article/3200b0658b504f1eadcc15761e4dd5e9
Autor:
Liam Simms, Fan Yu, Jessica Palmer, Kathryn Rudd, Edgar Trelles Sticken, Roman Wieczorek, Fiona Chapman, Lukasz Czekala, Matthew Stevenson, Grant O’Connell
Publikováno v:
Frontiers in Toxicology, Vol 4 (2022)
Combustible cigarette smoking is an established risk factor for cardiovascular disease. By contrast, the cardiotoxicity potential of non-combustible next generation nicotine products (NGPs), which includes heated tobacco products (HTPs) and electroni
Externí odkaz:
https://doaj.org/article/aac91d20500244e2a23128728628312c
Autor:
Fan Yu, Kathryn Rudd, Sarah Jean Pour, Edgar Trelles Sticken, Ole Dethloff, Roman Wieczorek, Thomas Nahde, Liam Simms, Fiona Chapman, Lukasz Czekala, Matthew Stevenson, Grant O'Connell
Publikováno v:
Applied In Vitro Toxicology. 8:24-35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a882e13ee9739b7131f01aea250c39bf
https://doi.org/10.1089/aivt.2021.0020
https://doi.org/10.1089/aivt.2021.0020
Autor:
Roman Wieczorek, Edgar Trelles Sticken, Sarah Jean Pour, Fiona Chapman, Karin Röwer, Sandra Otte, Matthew Stevenson, Liam Simms
Publikováno v:
Journal of Applied Toxicology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::676657d0a427f6aecd69ccbb0dd6d515
https://doi.org/10.1002/jat.4442
https://doi.org/10.1002/jat.4442
Autor:
Giel Hendriks, Roman Wieczorek, Jutta Pani, Liam Simms, Edgar Trelles Sticken, Lukasz Czekala, Remco Derr, Kathryn Rudd, Lisa Maria Bode, Fiona Chapman, Nynke Moelijker, Inger Brandsma, Tanvir Walele, Matthew Stevenson
Publikováno v:
Mutagenesis
In vitro (geno)toxicity assessment of electronic vapour products (EVPs), relative to conventional cigarette, currently uses assays, including the micronucleus and Ames tests. Whilst informative on induction of a finite endpoint and relative risk pose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4b5a25f353d6fbbec338ce3d9e9a3c3
https://doi.org/10.1093/mutage/geaa033
https://doi.org/10.1093/mutage/geaa033