Human antibody repertoire frequently includes antibodies to a bacterial biofilm associated protein.

Autor: Stefan Ryser, Edgar Tenorio, Angeles Estellés, Lawrence M Kauvar

Publikováno v: PLoS ONE, Vol 14, Iss 7, p e0219256 (2019)

We have previously described a native human monoclonal antibody, TRL1068, that disrupts bacterial biofilms by extracting from the biofilm matrix key scaffolding proteins in the DNABII family, which are present in both gram positive and gram negative

Externí odkaz: https://doaj.org/article/f3d9543f9995425d8634ecb15aa67f65

Human antibody repertoire frequently includes antibodies to a bacterial biofilm associated protein

Autor: Lawrence M. Kauvar, Stefan Ryser, Edgar Tenorio, Angeles Estelles

Publikováno v: PLoS ONE
PLoS ONE, Vol 14, Iss 7, p e0219256 (2019)

We have previously described a native human monoclonal antibody, TRL1068, that disrupts bacterial biofilms by extracting from the biofilm matrix key scaffolding proteins in the DNABII family, which are present in both gram positive and gram negative

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3f873a8f88cb09f64a0538ea25466da
https://pubmed.ncbi.nlm.nih.gov/31287831

A High-Affinity Native Human Antibody Neutralizes Human Cytomegalovirus Infection of Diverse Cell Types

Autor: Edgar Tenorio, Lenore Pereira, Michael A. McVoy, Mitsuru Tsuge, Neal DeChene, Minha Park, Stuart P. Adler, Keyi Liu, Matthew Petitt, Robert Stephenson, Takako Tabata, Lawrence M. Kauvar, June Fang-Hoover, Xiaohong Cui, Stote Ellsworth

Publikováno v: Kauvar, LM; Liu, K; Park, M; DeChene, N; Stephenson, R; Tenorio, E; et al.(2015). A high-affinity native human antibody neutralizes human cytomegalovirus infection of diverse cell types. Antimicrobial Agents and Chemotherapy, 59(3), 1558-1568. doi: 10.1128/AAC.04295-14. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/3f34n99s
Antimicrobial agents and chemotherapy, vol 59, iss 3

Human cytomegalovirus (HCMV) is the most common infection causing poor outcomes among transplant recipients. Maternal infection and transplacental transmission are major causes of permanent birth defects. Although no active vaccines to prevent HCMV i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40dab1126df9e8f10c0af806506fe7c5
https://doi.org/10.1128/aac.04295-14

High affinity anti-TIM-3 and anti-KIR monoclonal antibodies cloned from healthy human individuals

Autor: Edgar Tenorio, Mikhail L. Gishizky, Angeles Estelles, Lawrence M. Kauvar, Stefan Ryser

Publikováno v: PLoS ONE
PLoS ONE, Vol 12, Iss 7, p e0181464 (2017)

We report here the cloning of native high affinity anti-TIM-3 and anti-KIR IgG monoclonal antibodies (mAbs) from peripheral blood mononuclear cells (PBMC) of healthy human donors. The cells that express these mAbs are rare, present at a frequency of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c08ab662bc4dc423e4a99c27c06ea2e
https://pubmed.ncbi.nlm.nih.gov/28723950

Therapeutic anti-inflammatory mechanism of action of Type I interferons

Autor: Edgar Tenorio, Karl D. Mack

Publikováno v: Bioscience Hypotheses. 1:218-222

Interferon-beta is used for the treatment of relapsing-remitting multiple sclerosis and other Type I interferons are being studied as potential immune therapies for immune disorders. Yet, the therapeutic anti-inflammatory mechanism of action remains

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cf91b7c0bfd6a474a3b605d56500024e
https://doi.org/10.1016/j.bihy.2008.06.004