Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Edgar Hartsuiker"'
Autor:
Adel Alblihy, Reem Ali, Mashael Algethami, Alison A. Ritchie, Ahmed Shoqafi, Shatha Alqahtani, Katia A. Mesquita, Michael S. Toss, Paloma Ordóñez-Morán, Jennie N. Jeyapalan, Lodewijk Dekker, Martina Salerno, Edgar Hartsuiker, Anna M. Grabowska, Emad A. Rakha, Nigel P. Mongan, Srinivasan Madhusudan
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 13, p 10966 (2023)
The MRE11 nuclease is essential during DNA damage recognition, homologous recombination, and replication. BRCA2 plays important roles during homologous recombination and replication. Here, we show that effecting an MRE11 blockade using a prototypical
Externí odkaz:
https://doaj.org/article/313e0b2b4c2b41e2b2347e28697c5c61
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0132595 (2015)
During S-phase replication forks can stall at specific genetic loci. At some loci, the stalling events depend on the replisome components Schizosaccharomyces pombe Swi1 (Saccharomyces cerevisiae Tof1) and Swi3 (S. cerevisiae Csm3) as well as factors
Externí odkaz:
https://doaj.org/article/2e6104906a7f4a08a381f843c87f9ea7
Autor:
Kyoko Nakamura, Toshiaki Kogame, Hiroyuki Oshiumi, Akira Shinohara, Yoshiki Sumitomo, Keli Agama, Yves Pommier, Kimiko M Tsutsui, Ken Tsutsui, Edgar Hartsuiker, Tomoo Ogi, Shunichi Takeda, Yoshihito Taniguchi
Publikováno v:
PLoS Genetics, Vol 6, Iss 1, p e1000828 (2010)
Topoisomerase inhibitors such as camptothecin and etoposide are used as anti-cancer drugs and induce double-strand breaks (DSBs) in genomic DNA in cycling cells. These DSBs are often covalently bound with polypeptides at the 3' and 5' ends. Such modi
Externí odkaz:
https://doaj.org/article/7b2bc382af5b4b5b85a20ce23adb65aa
Autor:
Madhusudan, Adel Alblihy, Reem Ali, Mashael Algethami, Alison A. Ritchie, Ahmed Shoqafi, Shatha Alqahtani, Katia A. Mesquita, Michael S. Toss, Paloma Ordóñez-Morán, Jennie N. Jeyapalan, Lodewijk Dekker, Martina Salerno, Edgar Hartsuiker, Anna M. Grabowska, Emad A. Rakha, Nigel P. Mongan, Srinivasan
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 13; Pages: 10966
The MRE11 nuclease is essential during DNA damage recognition, homologous recombination, and replication. BRCA2 plays important roles during homologous recombination and replication. Here, we show that effecting an MRE11 blockade using a prototypical
Autor:
B. Paizs, Edgar Hartsuiker, D. Chaplin, S. Gollins, L. Boeckemeier, Cathrine Broberg Vågbø, R. Beardmore, M. U. Gasasira, R. Kraehenbuehl, S. A. E. Lambert, Ellen G Vernon, A. Keszthelyi, Hans E. Krokan
Publikováno v:
Science Advances
Science Advances, American Association for the Advancement of Science (AAAS), 2020, 6 (22), pp.eaaz4126. ⟨10.1126/sciadv.aaz4126⟩
Science Advances, American Association for the Advancement of Science (AAAS), 2020, 6 (22), pp.eaaz4126. ⟨10.1126/sciadv.aaz4126⟩
Mre11 exonuclease activity removes gemcitabine from the nascent strand during DNA replication.
The Mre11 nuclease is involved in early responses to DNA damage, often mediated by its role in DNA end processing. MRE11 mutations and aberrant expres
The Mre11 nuclease is involved in early responses to DNA damage, often mediated by its role in DNA end processing. MRE11 mutations and aberrant expres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82b38365e0b9886b2161bbf5a4a44ede
https://hal.archives-ouvertes.fr/hal-03008931/document
https://hal.archives-ouvertes.fr/hal-03008931/document
Autor:
Hongyun Tai, Xi Wang, Chandra Senan, Edgar Hartsuiker, Martina Salerno, Chester Blackburn, Wenxin Wang, Ian Ratcliffe
Publikováno v:
Data in Brief
The data presented in this manuscript presents the characterisation spectra of three hyperbranched polymers as discussed in the paper “Folic Acid and Rhodamine Labelled pH Responsive Hyperbranched Polymers: synthesis, characterisation and cell upta
Publikováno v:
European Polymer Journal. 120:109259
Here, we report the synthesis of novel folated and fluorescent labelled pH responsive hyperbranched polymers (HBPs) via reversible addition fragmentation chain-transfer (RAFT) co-polymerization of 2-propyl acrylic acid (PAA), 2-(dimethylamino) ethyl
Publikováno v:
Cold Spring Harbor protocols, vol 2018, iss 2
Epistasis mapping, in which the phenotype that emerges from combining pairs of mutations is measured quantitatively, is a powerful tool for unbiased study of gene function. When performed at a large scale, this approach has been used to assign functi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c675adccb622d494b58b54ec50908586
https://escholarship.org/uc/item/55h327t3
https://escholarship.org/uc/item/55h327t3
Autor:
Patrick van Eijk, Shirong Yu, Rolf Kraehenbuehl, Edgar Hartsuiker, Raymond Waters, Simon H. Reed, Neil Humphryes, Zheng Zhou
Publikováno v:
Nucleic Acids Research
Regulating gene expression programmes is a central facet of the DNA damage response. The Dun1 kinase protein controls expression of many DNA damage induced genes, including the ribonucleotide reductase genes, which regulate cellular dNTP pools. Using
Autor:
Isabelle, Colson, Edgar, Hartsuiker
Publikováno v:
Cold Spring Harbor protocols. 2018(2)
In laboratories in which a colony-replicating robot is not available, manual replication provides a good, low-cost alternative for genetic interaction screening using the Pombe Epistasis Mapper (PEM) system. The protocol presented here describes the