The nuclear envelope protein, LAP1B, is a novel protein phosphatase 1 substrate.

Autor: Mariana Santos, Sandra Rebelo, Paula J M Van Kleeff, Connie E Kim, William T Dauer, Margarida Fardilha, Odete A da Cruz E Silva, Edgar F da Cruz E Silva

Publikováno v: PLoS ONE, Vol 8, Iss 10, p e76788 (2013)

Protein phosphatase 1 (PP1) binding proteins are quintessential regulators, determining substrate specificity and defining subcellular localization and activity of the latter. Here, we describe a novel PP1 binding protein, the nuclear membrane protei

Externí odkaz: https://doaj.org/article/aa03d26da1d141e18470d8003e4c191a

Genetic mutations strengthen functional association of LAP1 with DYT1 dystonia and muscular dystrophy

Autor: Odete A. B. da Cruz e Silva, Edgar F. da Cruz e Silva, Sandra Rebelo

Publikováno v: Mutation Research/Reviews in Mutation Research. 766:42-47

Lamina-associated polypeptide 1 (LAP1) is a ubiquitously expressed integral protein of the inner nuclear membrane. It interacts physically with lamins, torsinA, emerin and protein phosphatase 1; potentially providing a pivotal mechanism for transduci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c529cf6b36be730ec86d28564390110
https://doi.org/10.1016/j.mrrev.2015.07.004

'OMICS' of Human Sperm: Profiling Protein Phosphatases

Autor: Odete A. B. da Cruz e Silva, Luís Korrodi-Gregório, Alberto Barros, Mónica Ferreira, Mário Sousa, Sandra Vieira, Edgar F. da Cruz e Silva, Sandra Rebelo, Margarida Fardilha, Steven L. Pelech, Vladimiro Silva

Publikováno v: OMICS: A Journal of Integrative Biology. 17:460-472

Phosphorylation is a major regulatory mechanism in eukaryotic cells performed by the concerted actions of kinases and phosphatases (PPs). Protein phosphorylation has long been relevant to sperm physiology, from acquisition of motility in the epididym

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3121d63106f3616f444854b9f522f0a2
https://doi.org/10.1089/omi.2012.0119

TCTEX1D4, a novel protein phosphatase 1 interactor: connecting the phosphatase to the microtubule network

Autor: Luís Korrodi-Gregório, Joana Silva, Odete A. B. da Cruz e Silva, Joana Abrantes, Pedro J. Esteves, Margarida Fardilha, Edgar F. da Cruz e Silva, Maria João Freitas, Sara L. C. Esteves, Ann-Kristin Brauns, Georg H. Lüers, Sandra Vieira

Publikováno v: Biology Open, Vol 2, Iss 5, Pp 453-465 (2013)
Recercat. Dipósit de la Recerca de Catalunya
instname
Dipòsit Digital de la UB
Universidad de Barcelona
Biology Open

Summary Reversible phosphorylation plays an important role as a mechanism of intracellular control in eukaryotes. PPP1, a major eukaryotic Ser/Thr-protein phosphatase, acquires its specificity by interacting with different protein regulators, also kn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b33c75ca124e32affa9603ed92b31ada
http://bio.biologists.org/content/2/5/453

Identification of the human testis protein phosphatase 1 interactome

Autor: Sandra Rebelo, Patricia T.W. Cohen, Sara C. Domingues, Luís Korrodi-Gregório, Sara L. C. Esteves, Odete A. B. da Cruz e Silva, Ana Paula Vintém, Margarida Fardilha, Edgar F. da Cruz e Silva, Nick Morrice

Publikováno v: Biochemical Pharmacology. 82:1403-1415

Protein phosphorylation is a critical regulatory mechanism in cellular signalling. To this end, PP1 is a major eukaryotic serine/threonine-specific phosphatase whose cellular functions, in turn, depend on complexes it forms with PP1 interacting prote

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4e85f4e2b324cb74b63f9745240f6d1
https://doi.org/10.1016/j.bcp.2011.02.018