Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Edgar E. Ohnhaus"'
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 17:9-12
Experimental evidence suggested that H2-receptor antagonists may inhibit not only hepatic but also adrenal cytochrome P-450 dependent monooxygenases. Therefore, the effects of ranitidine (150 mg b.i.d. over 14 days) on cortisol metabolism and antipyr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55139d6fef0c2fe4dbe8c43b75fcef96
https://doi.org/10.1007/bf03189981
https://doi.org/10.1007/bf03189981
Publikováno v:
Clinical Pharmacology and Therapeutics. 48:575-581
Serum γ-glutamyltransferase is used as a marker of hepatic enzyme induction. The kidney contains high activities of γ-glutamyltransferase in the brush border membrane of the proximal tubule, from which it is released into urine. This study investig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47ec5aefa93db539880c039d332ead02
https://doi.org/10.1038/clpt.1990.194
https://doi.org/10.1038/clpt.1990.194
Publikováno v:
Clinical Pharmacology and Therapeutics. 47:698-705
Induction of hepatic monooxygenases reflected by 7-ethoxycoumarin O-deethylase has been proposed to be associated with the initiation of liver damage. This study investigated a possible correlation between 7-ethoxycoumarin O-deethylase, reduced nicot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d5e2126acfd3b0f0aa90c99fe16e836
https://doi.org/10.1038/clpt.1990.96
https://doi.org/10.1038/clpt.1990.96
Publikováno v:
European journal of clinical pharmacology. 42(6)
The effects of three different enzyme-inducing drugs (antipyrine 1200 mg, phenobarbital 100 mg, rifampicin 600 mg per day for 7 days) on plasma and urinary testosterone concentrations, plasma gonadotropin levels, antipyrine kinetics, and urinary 6 be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86e17440958bf457de1a63bde85bd58c
https://pubmed.ncbi.nlm.nih.gov/1623905
https://pubmed.ncbi.nlm.nih.gov/1623905
Publikováno v:
Cardiovascular drugs and therapy. 5(4)
The pharmacokinetics of encainide were investigated in 10 patients with cirrhosis and 10 matched controls following single intravenous (IV, 25 mg), single oral (so, 25 mg), and multiple oral (mo, 25 mg thrice daily over 5 days) dosing. The hepatic ox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2610959e7927391ea4c8cd15ccc93698
https://pubmed.ncbi.nlm.nih.gov/1909559
https://pubmed.ncbi.nlm.nih.gov/1909559
Publikováno v:
British journal of clinical pharmacology. 30(1)
1. The effect of chronic administration of oral contraceptive steroids (OCS) on the pharmacokinetics of the oral anticoagulant phenprocoumon was investigated in seven healthy females. 2. Plasma concentrations of phenprocoumon and the urinary recovery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64fb1d0c2cf1ed2b7d87194ed3e14066
https://pubmed.ncbi.nlm.nih.gov/2390422
https://pubmed.ncbi.nlm.nih.gov/2390422
Publikováno v:
European journal of clinical pharmacology. 39(3)
We have studied the pharmacokinetics of phenprocoumon with and without co-administration of frusemide and probenecid in two groups of 17 healthy volunteers. Frusemide 40 mg b.i.d. for 7 days did not interact with phenprocoumon to a significant extent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdf23e34bc00a92dd68209e238cb090b
https://pubmed.ncbi.nlm.nih.gov/2257863
https://pubmed.ncbi.nlm.nih.gov/2257863
Publikováno v:
European Journal of Clinical Pharmacology. 44:203-204
Chlormethiazole is a strong inhibitor of cytochrome P-450-dependent monooxygenases in isolated human liver microsomes. To assess its effect in vivo, we measured the pharmacokinetic parameters of antipyrine (1.2 g orally) and tolbutamide (0.5 g i. v.)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28c1da5685110b5e88c87034ccebd516
https://doi.org/10.1007/bf00315482
https://doi.org/10.1007/bf00315482
Publikováno v:
British Journal of Clinical Pharmacology. 31:120-121
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7828549903d2748aa99f15b3583d79f
https://doi.org/10.1111/j.1365-2125.1991.tb03871.x
https://doi.org/10.1111/j.1365-2125.1991.tb03871.x
Publikováno v:
Clinical Pharmacology and Therapeutics. 42:148-156
The elimination of diazepam and antipyrine and the urinary excretion of their metabolites were investigated in 21 healthy volunteers before and after 7 days of administration of antipyrine, 1200 mg, and rifampin, 600 or 1200 mg. After administration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ee6ed985d912af9b403954880e38da3
https://doi.org/10.1038/clpt.1987.125
https://doi.org/10.1038/clpt.1987.125