Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Edgar E, Nollet"'
Autor:
Verena Schwach, Rolf H. Slaats, Carla Cofiño-Fabres, Simone A. ten Den, José M. Rivera-Arbeláez, Maureen Dannenberg, Chiara van Boheemen, Marcelo C. Ribeiro, Sabina Y. van der Zanden, Edgar E. Nollet, Jolanda van der Velden, Jacques Neefjes, Lu Cao, Robert Passier
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109139- (2024)
Summary: Cardiotoxicity remains a major cause of drug withdrawal, partially due to lacking predictability of animal models. Additionally, risk of cardiotoxicity following treatment of cancer patients is treatment limiting. It is unclear which patient
Externí odkaz:
https://doaj.org/article/53a15164b1784b66b4caea6027524cc5
Autor:
Berke Gürkan, Hessel Poelman, Liza Pereverzeva, Danielle Kruijswijk, Alex F. de Vos, Anouk G. Groenen, Edgar E. Nollet, Kanin Wichapong, Esther Lutgens, Tom van der Poll, Jiangfeng Du, W. Joost Wiersinga, Gerry A. F. Nicolaes, Cornelis van ‘t Veer
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2024)
The anti-inflammatory interleukin-1 receptor associated kinase-M (IRAK-M) is a negative regulator of MyD88/IRAK-4/IRAK-1 signaling. However, IRAK-M has also been reported to activate NF-κB through the MyD88/IRAK-4/IRAK-M myddosome in a MEKK-3 depend
Externí odkaz:
https://doaj.org/article/0c33abacff5a46efbd205dff44b03560
Autor:
Edgar E. Nollet, Sila Algül, Max Goebel, Saskia Schlossarek, Nicole N. van der Wel, Judith J.M. Jans, Mark A. van de Wiel, Jaco C. Knol, Thang V. Pham, Sander R. Piersma, Richard de Goeij-de Haas, Jill Hermans, Jan Bert van Klinken, Michel van Weeghel, Riekelt H. Houtkooper, Lucie Carrier, Connie R. Jimenez, Diederik W.D. Kuster, Jolanda van der Velden
Publikováno v:
Journal of Molecular and Cellular Cardiology Plus, Vol 6, Iss , Pp 100050- (2023)
Background and aim: Phenotypic expression of hypertrophic cardiomyopathy (HCM) and disease course are associated with unfavorable metabolic health. We investigated if Western diet (WD) feeding is sufficient to trigger cardiac hypertrophy and dysfunct
Externí odkaz:
https://doaj.org/article/a35423357cb242d7a31ba3d7bed60292
Autor:
Sofija Vučković, Rafeeh Dinani, Edgar E. Nollet, Diederik W. D. Kuster, Jan Willem Buikema, Riekelt H. Houtkooper, Miranda Nabben, Jolanda van der Velden, Birgit Goversen
Publikováno v:
Stem Cell Research & Therapy, Vol 13, Iss 1, Pp 1-19 (2022)
Abstract Background Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) have emerged as a powerful tool for disease modeling, though their immature nature currently limits translation into clinical practice. Maturation strategies increasi
Externí odkaz:
https://doaj.org/article/bb40feeeeb3d4261ada3ef35f1e56c6f
Autor:
Edgar E. Nollet, B. Daan Westenbrink, Rudolf A. de Boer, Diederik W. D. Kuster, Jolanda van der Velden
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 22 (2020)
Abstract Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiomyopathy and is characterized by asymmetric septal thickening and diastolic dysfunction. More than 1500 mutations in genes encoding sarcomere proteins are associated with H
Externí odkaz:
https://doaj.org/article/604db015d6844cd691235e57ea3eeac1
Autor:
Edgar E. Nollet, Emmy M. Manders, Max Goebel, Valentijn Jansen, Cord Brockmann, Jorrit Osinga, Jolanda van der Velden, Michiel Helmes, Diederik W. D. Kuster
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
The chambers of the heart fulfill different hemodynamic functions, which are reflected in their structural and contractile properties. While the atria are highly elastic to allow filling from the venous system, the ventricles need to be able to produ
Externí odkaz:
https://doaj.org/article/828eff94062f4859ba1a8aa52304554c
Autor:
Edgar E Nollet, Inez Duursma, Anastasiya Rozenbaum, Moritz Eggelbusch, Rob C I Wüst, Stephan A C Schoonvelde, Michelle Michels, Mark Jansen, Nicole N van der Wel, Kenneth C Bedi, Kenneth B Margulies, Jeff Nirschl, Diederik W D Kuster, Jolanda van der Velden
Publikováno v:
Nollet, E E, Duursma, I, Rozenbaum, A, Eggelbusch, M, Wüst, R C I, Schoonvelde, S A C, Michels, M, Jansen, M, van der Wel, N N, Bedi, K C, Margulies, K B, Nirschl, J, Kuster, D W D & van der Velden, J 2023, ' Mitochondrial dysfunction in human hypertrophic cardiomyopathy is linked to cardiomyocyte architecture disruption and corrected by improving NADH-driven mitochondrial respiration ', European heart journal . https://doi.org/10.1093/eurheartj/ehad028
European heart journal. Oxford University Press
European heart journal. Oxford University Press
Aims Genetic hypertrophic cardiomyopathy (HCM) is caused by mutations in sarcomere protein-encoding genes (i.e. genotype-positive HCM). In an increasing number of patients, HCM occurs in the absence of a mutation (i.e. genotype-negative HCM). Mitocho
Autor:
Bracy, Fertig, Jiayue, Ling, Edgar E, Nollet, Sara, Dobi, Tara, Busiau, Kiyotake, Ishikawa, Kelly, Yamada, Ahyoung, Lee, Changwon, Kho, Lauren, Wills, Amy J, Tibbo, Mark, Scott, Kirsten, Grant, Kenneth S, Campbell, Emma J, Birks, Niall, MacQuaide, Roger, Hajjar, Godfrey L, Smith, Jolanda, van der Velden, George S, Baillie
Publikováno v:
The FEBS journal. 289(20)
Post-translational modification of the myofilament protein troponin I by phosphorylation is known to trigger functional changes that support enhanced contraction and relaxation of the heart. We report for the first time that human troponin I can also
Autor:
Vincent M. Christoffels, Bjarke Jensen, Rob C. I. Wüst, Inge Dierx, Damián Sánchez-Quintana, Antoon F. M. Moorman, Jaeike W. Faber, Allard C. van der Wal, Diederik W. D. Kuster, Janneke Hummelink, Edgar E. Nollet
Trabecular muscle makes up most of the ventricular wall of the human embryo. It is presumed that compaction in the foetal period changes ventricular wall morphology by converting weaker trabeculae to stronger compact muscle. Using developmental serie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::266779a7ea1c5c7f78b98fea3801ffda
https://doi.org/10.21203/rs.3.rs-608669/v1
https://doi.org/10.21203/rs.3.rs-608669/v1
Autor:
Faber JW; Department of Medical Biology, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centres, Amsterdam, the Netherlands., Wüst RCI; Laboratory for Myology, Faculty of Behavioural and Movement Sciences, Amsterdam Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands., Dierx I; Department of Medical Biology, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centres, Amsterdam, the Netherlands., Hummelink JA; Department of Medical Biology, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centres, Amsterdam, the Netherlands., Kuster DWD; Department of Physiology, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centres, Amsterdam, the Netherlands., Nollet E; Department of Physiology, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centres, Amsterdam, the Netherlands., Moorman AFM; Department of Medical Biology, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centres, Amsterdam, the Netherlands., Sánchez-Quintana D; Department of Anatomy and Cell Biology, Universidad de Extremadura, Badajoz, Spain., van der Wal AC; Department of Pathology, Amsterdam University Medical Centres, Amsterdam, the Netherlands., Christoffels VM; Department of Medical Biology, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centres, Amsterdam, the Netherlands., Jensen B; Department of Medical Biology, Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centres, Amsterdam, the Netherlands.
Publikováno v:
IScience [iScience] 2022 Oct 17; Vol. 25 (11), pp. 105393. Date of Electronic Publication: 2022 Oct 17 (Print Publication: 2022).